A5084527317- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Xenotransplantation and immune response
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Zoonotic diseases and public health
- Vector-Borne Animal Diseases
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- Blood groups and transfusion
- Plant Virus Research Studies
- Energy and Environment Impacts
- Lichen and fungal ecology
- Mosquito-borne diseases and control
- Historical, Literary, and Cultural Studies
- Polyomavirus and related diseases
- Poxvirus research and outbreaks
- Cuban History and Society
University of Bern
1902-2023
Centers for Disease Control and Prevention
1991
Abstract We report the identification of a neurotropic astrovirus associated with encephalitis in sheep. This virus is genetically almost identical to an recently described neurologically diseased cattle. The similarity indicates that astroviruses same genotype may cause different species.
The rapid spread of the SARS-CoV-2 lineages B.1.1.7 (N501Y.V1) throughout UK, B.1.351 (N501Y.V2) in South Africa, and P.1 (B.1.1.28.1; N501Y.V3) Brazil has led to definition variants concern (VoCs) recommendations for lineage specific surveillance. In Switzerland, during last weeks December 2020, we established a nationwide screening protocol across multiple laboratories, focusing first on epidemiological microbiological definitions. January 2021, validated implemented an N501Y-specific PCR...
Two new astrovirus assays, a rapid biotin-avidin enzyme immunoassay (EIA) and RNA probe hybridization, were developed compared with an established assay, indirect EIA, immune electron microscopy. Sensitivity specificity evaluated by using screening panel of 22 astrovirus-positive 305 astrovirus-negative fecal specimens. The assay was equivalent in performance to the reference both could detect about 10 ng viral protein. Although more sensitive than either EIA higher dilutions virus tissue...
European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting potential hazard to consumers. To address these concerns, we applied metatranscriptomics identify disease-associated viruses in Switzerland. Unexpectedly, clinically diseased detected novel freshwater filoviruses, hantavirus, previously unknown rhabdovirus....
The small, single-stranded positive-sense RNA astroviruses are mostly known to be enteric viruses. In recent years, though, different were reported in association with neurological disease various species. cattle, two distinct neurotropic astrovirus genotype species described numerous cases of nonsuppurative encephalomyelitis, one these viruses also similar circumstances several sheep. Here, we retrieved archived formalin-fixed, paraffin-embedded brain tissues a muskox diagnosed comparable...
In mammals, the small, positive-sense single-stranded RNA astroviruses are known as being mostly enterotropic and host-specific. Over past years, however, they were identified several times in central nervous system tissues of humans, minks, cattle, sheep pigs with nonsuppurative inflammatory disease that organ system. We recently reported such neurotropic astroviruses, amongst which bovine astrovirus CH15 (BoAstV-CH15) two cows, ovine CH16 (OvAstV-CH16) a sheep, genetically almost identical...
A novel bovine astrovirus genotype species (BoAstV-CH13/NeuroS1) was recently identified in brain tissues of cattle as a plausible cause encephalitis. The purpose the present study to develop and validate real time RT-PCR assays for detection BoAstV-CH13/NeuroS1 cattle. Three different primer-probe combinations were designed based on full-genome sequences 11 strains cattle, established three distinct one-step protocols. These protocols compared regarding their diagnostic performance using...
An 8-year-old alpaca was admitted to the emergency service of Clinic for Ruminants in Bern due a reduced general condition and progressive neurological signs. Despite supportive treatment, its deteriorated animal had be euthanized. Histopathological analysis revealed severe non-suppurative polioencephalomyelitis with neuronal necrosis, most likely viral origin. We detected abundant labelling antibodies directed against two different epitopes Bovine Astrovirus CH13/NeuroS1...
Astroviruses (AstV) are single-stranded, positive-sense RNA viruses, best known for causing diarrhea in humans and also found many other mammals; those, the relevance gastroenteritis remains unclear. Recently described neurotropic AstV showed associations with encephalitis as well mammals. In Switzerland, two different were identified cattle, one a sheep. The high genetic similarity between ovine of bovine strengthens hypothesis an interspecies transmission. humans, associated human stool...
Tissues from two cows with neurological signs that were admitted to the Vetsuisse Faculty under suspicion of rabies and bovine spongiform encephalopathy (BSE), respectively, further analyzed for this case report. After histopathological examination exclusion BSE rabies, animals diagnosed etiologically unresolved disseminated non-suppurative encephalitis. Using next-generation sequencing, we detected full genome polyomavirus 2 (BoPyV2) in brain samples both animals. This virus has been...
We report on genomic sequences of human enteroviruses (EVs) that were identified in respiratory samples Bern, Switzerland, 2018 and 2019. Besides providing for coxsackievirus A2, echovirus 11, 30, we determined the rare EV-D68 EV-C105 genotypes circulating Switzerland.
Coronaviruses are causing severe respiratory and enteric diseases in humans animals. Here, we report an outbreak of equine coronavirus disease adult horses, detected by a voluntary syndromic surveillance scheme for Switzerland. This allowed rapid concerted action to diagnose contain the disease.
Abstract The rapid spread of the SARS-CoV-2 lineages B.1.1.7 (N501Y.V1) throughout UK, B.1.351 (N501Y.V2) in South Africa, and P.1 (B.1.1.28.1; N501Y.V3) Brazil has led to definition variants concern (VoCs) recommendations by European Center for Disease Prevention Control (ECDC) World Health Organization (WHO) lineage specific surveillance. In Switzerland, during last weeks December 2020, we established a nationwide screening protocol across multiple laboratories, focusing first on...
Abstract Background The majority of emerging infectious diseases in humans are animal origin, and many them caused by neuropathogenic viruses. Many cases neurological disease encephalitis livestock remain etiologically unresolved, posing a constant threat to human health. Thus, continuous extension our knowledge the repertoire viruses prone infect central nervous system (CNS) is vital for pathogen monitoring early detection Using high-throughput sequencing (HTS) bioinformatics, we discovered...