A5074791482- Viral Infections and Vectors
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Poxvirus research and outbreaks
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Insect and Pesticide Research
- Bacillus and Francisella bacterial research
- Bartonella species infections research
- Virus-based gene therapy research
- Rabies epidemiology and control
- Plant Virus Research Studies
- Leptospirosis research and findings
- Bacteriophages and microbial interactions
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Outbreaks Research
- Microbial infections and disease research
- Fire effects on ecosystems
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Dermatological diseases and infestations
- Brucella: diagnosis, epidemiology, treatment
- Microbial Metabolic Engineering and Bioproduction
Leipzig University
2016-2025
Institute of Medical Microbiology and Hygiene
1993-2020
Friedrich-Loeffler-Institut
2016
BOKU University
2011-2014
Universität der Bundeswehr München
2004-2013
Institut für Mikrobiologie der Bundeswehr
2004-2013
Fraunhofer Austria
2013
TU Wien
2007-2013
Czech Academy of Sciences, Institute of Microbiology
2006-2013
Brigham and Women's Hospital
1985-2008
Two Gram-negative, non-motile, non-spore-forming, coccoid bacteria (strains CCM 4915T and 4916), isolated from clinical specimens of the common vole Microtus arvalis during an epizootic in Czech Republic 2001, were subjected to a polyphasic taxonomic study. On basis 16S rRNA (rrs) recA gene sequence similarities, both isolates allocated genus Brucella. Affiliation Brucella was confirmed by DNA–DNA hybridization studies. Both strains reacted equally with M-monospecific antiserum lysed...
A Gram-negative, non-motile, non-spore-forming coccoid bacterium (strain BO1(T)) was isolated recently from a breast implant infection of 71-year-old female patient with clinical signs brucellosis. Affiliation strain BO1(T) to the genus Brucella confirmed by means polyamine pattern, polar lipid profile, fatty acid quinone system, DNA-DNA hybridization studies and insertion sequence 711 (IS711)-specific PCR. Strain harboured four five copies Brucella-specific element IS 711, displaying unique...
Protein secretion is an essential process for living organisms. In eukaryotes, this encompasses numerous steps mediated by several hundred cellular proteins. The core functions of translocation through the endoplasmic reticulum membrane, primary glycosylation, folding and quality control, vesicle-mediated are similar from yeasts to higher eukaryotes. However, recent research has revealed significant functional differences between mammalian cells, even among diverse yeast species. This review...
The goal of this paper is to present up-to-date maps depicting the geographical distribution Dermacentor species in Europe based on georeferenced sampling sites. Therefore, a dataset was compiled, resulting 1286 D. marginatus (Sulzer, 1776) and 1209 reticulatus (Fabricius, 1794) locations. Special emphasis given region European Alps presumable climate barrier mountains overlaps both as well situation eastern countries. For latter newly described findings comprise 59 locations Romania 62...
Background. An outbreak of chikungunya virus infection emerged in the southwest Indian Ocean islands 2005, spread out to India, and resulted an ongoing that has involved >1.5 million patients, including travelers who have visited these areas. Methods. Our study investigated 69 developed signs symptoms compatible with fever after returning home from countries epidemic. Twenty cases were confirmed by serological analysis, polymerase chain reaction, and/or cell culture investigated. Results....
Arboviruses are transmitted in nature exclusively or to a major extend by arthropods. They belong the most important viruses invading new areas world and their occurrence is strongly influenced climatic changes due life cycle of transmitting vectors. Several arboviruses have emerged regions during last years, like West Nile virus (WNV) Americas, Usutu (USUV) Central Europe, Rift Valley fever (RVFV) Arabian Peninsula. In instances ways introduction into not known. Infections acquired stays...
This study aimed to identify the causative agent of mass mortality in wild and captive birds southwest Germany gather insights into phylogenetic relationship spatial distribution pathogen. Since June 2011, 223 dead were collected tested for presence viral pathogens. Usutu virus (USUV) RNA was detected by real-time RT-PCR 86 representing 6 species. The isolated cell culture from heart 18 Blackbirds (Turdus merula). USUV-specific antigen demonstrated immunohistochemistry brain, heart, liver,...
The production of recombinant proteins is frequently enhanced at the levels transcription, codon usage, protein folding and secretion. Overproduction heterologous proteins, however, also directly affects primary metabolism producing cells. By incorporation a into genome scale metabolic model yeast Pichia pastoris, effects overproduction were simulated gene targets for deletion or overexpression productivity predicted. Overexpression localized in pentose phosphate pathway TCA cycle, while...
Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds sporadic infection in humans. The dynamics USUV spread evolution its natural hosts are unknown. Here, we present phylogeny evolutionary history all available strains, including 77 newly sequenced complete genomes from a variety host species at temporal spatial scaled resolution. results showed that can be classified into six distinct lineages recent common...
The aims of this study were to evaluate the host-tick-pathogen interface Babesia spp. and Anaplasma phagocytophilum in restored areas both questing host-attached Ixodes ricinus Dermacentor reticulatus their small mammalian hosts. Questing ticks collected from 5 sites within city Leipzig, Germany, 2009. Small mammals trapped at 3 during 2010 2011. DNA extracts I. D. several tissue types (the majority bank voles yellow-necked mice), investigated by PCR followed sequencing for occurrence...
Dogs are the main reservoir of Leishmania infantum and in some countries have been regularly culled as part government policy to control visceral leishmaniasis. At 13th Symposium Companion Vector-Borne Diseases World Forum Windsor, UK, March 19-22, 2018, we consolidated a consensus statement regarding usefulness dog culling means controlling The highlighted futility infected dogs, whether healthy or sick, measure domestic L. reduce risk for
ABSTRACT Cell culture isolates of salmon pancreas disease virus (SPDV) farmed Atlantic and sleeping (SDV) rainbow trout were compared. Excluding the poly(A) tracts, genomic nucleotide sequences SPDV SDV RNAs include 11,919 11,900 nucleotides, respectively. Phylogenetic analysis places between New World viruses Venezuelan equine encephalitis Eastern Old Aura Sindbis virus. When compared to each other, show 91.1% sequence identity over their complete genomes, with 95 93.6% amino acid...
From the mandibular lymph nodes of wild red foxes (Vulpes vulpes) hunted in region Gmünd, Lower Austria, two gram-negative, oxidase- and urease-positive, coccoid rod-shaped bacteria (strains 257 284) were isolated. Cells fast growing, nonmotile, agglutinated with monospecific anti-Brucella (M) serum. Both strains biochemically identified as Ochrobactrum anthropi by using API 20NE test. However, sequencing 16S rRNA recA genes clearly 284 Brucella spp. Further molecular analysis omp2a/b gene...
As a follow-up of retrospective survey on tick borne-encephalitis (TBE) in 2008, the European Network for Diagnostics 'Imported' Viral Diseases launched new 2010, to collect broader information TBE prevalence between 2007 and 2009 observe possible changes compared previous data. A two-part questionnaire was mailed contact points all Union (EU) Member States four non-EU countries (Bosnia Herzegovina, Norway, Russia, Switzerland). The first part identical 2008 survey, requesting case...