Tracey Goldstein
A5011254428- Viral Infections and Vectors
- Zoonotic diseases and public health
- Marine animal studies overview
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Toxoplasma gondii Research Studies
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Marine Toxins and Detection Methods
- Rabies epidemiology and control
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Bat Biology and Ecology Studies
- Nicotinic Acetylcholine Receptors Study
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- Aquaculture disease management and microbiota
- Bartonella species infections research
- Vector-Borne Animal Diseases
- Marine and coastal ecosystems
- Influenza Virus Research Studies
- Turtle Biology and Conservation
Colorado State University
2025
University of California, Davis
2014-2023
University of Illinois Urbana-Champaign
2022-2023
Chicago Zoological Society
2022
University of Ghana
2022
Noguchi Memorial Institute for Medical Research
2022
Ghana Health Service
2022
Office of Infectious Diseases
2021
Baylor College of Medicine
2020
San Diego Zoo Institute for Conservation Research
2020
Since the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Syndrom (MERS-CoV) it has become increasingly clear that bats are important reservoirs CoVs. Despite this, only 6% all CoV sequences in GenBank from bats. The remaining 94% largely consist known pathogens public health or agricultural significance, indicating current research effort is heavily biased towards describing diseases rather than 'pre-emergent' diversity Our study addresses this critical...
The majority of emerging zoonoses originate in wildlife, and many are caused by viruses. However, there no rigorous estimates total viral diversity (here termed "virodiversity") for any wildlife species, despite the utility this to future surveillance control zoonoses. In case study, we repeatedly sampled a mammalian host known harbor zoonotic pathogens (the Indian Flying Fox, Pteropus giganteus) used PCR with degenerate family-level primers discover analyze occurrence patterns 55 viruses...
The evolutionary origins of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) are unknown. Current evidence suggests that insectivorous bats likely to be the original source, as several 2c CoVs have been described from various species in family Vespertilionidae Here, we describe a MERS-like CoV identified Pipistrellus cf. hesperidus bat sampled Uganda (strain PREDICT/PDF-2180), further supporting hypothesis source MERS-CoV. Phylogenetic analysis showed PREDICT/PDF-2180 is...
Abstract Most human infectious diseases, especially recently emerging pathogens, originate from animals and ongoing disease transmission to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification spread diseases is essential for prioritizing surveillance predicting future emergence risk. We examine animal hosts mechanisms spillover viruses date discover that with high host plasticity (i.e. taxonomically...
The death toll and economic loss resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are stark reminders that we vulnerable to zoonotic viral threats. Strategies needed identify characterize animal viruses pose greatest risk of spillover spread in humans inform public health interventions. Using expert opinion scientific evidence, identified host, viral, environmental factors contributing virus humans. We then developed a ranking framework interactive web...
Abstract Knowledge of the origin and reservoir coronavirus responsible for ongoing COVID-19 pandemic is still fragmentary. To date, closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled Yunnan province, China. Here we describe identification related coronaviruses two shameli Cambodia 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely SARS-CoV-2, exception a region spike,...
As the world continues to react and respond inefficiently emerging infectious diseases, such as Middle Eastern Respiratory Syndrome Ebola Zika viruses, a growing transdisciplinary community has called for more proactive holistic approach prevention preparedness – One Health. Such an presents important opportunities reduce impact of disease emergence events also mitigate future through improved cross-sectoral coordination. In attempt provide proof concept utility Health approach, US Agency...
Harmful algal blooms are increasing worldwide, including those of Pseudo-nitzschia spp. producing domoic acid off the California coast. This neurotoxin was first shown to cause mortality marine mammals in 1998. A decade monitoring sea lion (Zalophus californianus) health since then has indicated that changes symptomatology and epidemiology toxicosis this species associated with increase toxigenic blooms. Two separate clinical syndromes now exist: acute as been previously documented, a second...
Bats are reservoirs for a wide range of human pathogens including Nipah, Hendra, rabies, Ebola, Marburg and severe acute respiratory syndrome coronavirus (CoV). The recent implication novel beta (β)-CoV as the cause fatal disease in Middle East emphasizes importance surveillance CoVs that have potential to move from bats into population. In screen 606 42 different species Campeche, Chiapas Mexico City we identified 13 distinct CoVs. Nine were alpha (α)-CoVs; four β-CoVs. Twelve novel....
Abstract Marburg virus (MARV) causes sporadic outbreaks of severe disease (MVD). Most MVD originated in East Africa and field studies Africa, South Zambia, Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus ) as a natural reservoir. However, largest recorded outbreak with highest case–fatality ratio happened 2005 Angola, where direct spillover from bats was not shown. Here, collaborative by Centers for Disease Control Prevention, Njala University, University California,...
Outbreaks of emerging coronaviruses in the past two decades and current pandemic a novel coronavirus (SARS-CoV-2) that emerged China highlight importance this viral family as zoonotic public health threat. To gain better understanding presence diversity wildlife at wildlife-human interfaces three southern provinces Viet Nam 2013–2014, we used consensus Polymerase Chain Reactions to detect sequences. In comparison previous studies, observed high proportions positive samples among field rats...
The recent emergence of bat-borne zoonotic viruses warrants vigilant surveillance in their natural hosts. Of particular concern is the family coronaviruses, which includes causative agents severe acute respiratory syndrome (SARS), Middle East (MERS), and most recently, Coronavirus Disease 2019 (COVID-19), an epidemic illness originating from Wuhan, China December 2019. Viral detection, discovery, activities were undertaken Myanmar to identify animals at high risk contact interfaces with...
Abstract Knowledge of the origin and reservoir coronavirus responsible for ongoing COVID-19 pandemic is still fragmentary. To date, closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled Yunnan province, China. Here we describe identification related coronaviruses two shameli Cambodia 2010. Metagenomic sequencing identified nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely SARS-CoV-2, exception a small region...
Abstract Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2 are not phylogenetically closely related; however, both use the angiotensin-converting enzyme 2 (ACE2) receptor in humans for cell entry. This is a universal sarbecovirus trait; example, many known sarbecoviruses related to SARS-CoV-1 have two deletions binding domain of spike protein that render them incapable using human ACE2. Here, we report three sequences novel from Rwanda Uganda intermediate...
Abstract It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate wildlife are inherently structured (inferring predictability) by looking at assembled through deterministic (often predictable) or stochastic (not processes. We sample macaque faeces across nine sites Bangladesh and use consensus PCR sequencing to discover 184 viruses from 14 families. then network modelling statistical null-hypothesis testing show the presence of non-random...
Abstract Climate change-driven alterations in Arctic environments can influence habitat availability, species distributions and interactions, the breeding, foraging, health of marine mammals. Phocine distemper virus (PDV), which has caused extensive mortality Atlantic seals, was confirmed sea otters North Pacific Ocean 2004, raising question whether reductions ice could increase contact between sub-Arctic mammals lead to viral transmission across Ocean. Using data on PDV exposure infection...
There is little doubt that aerosols play a major role in the transmission of SARS-CoV-2. The significance presence and infectivity this virus on environmental surfaces, especially hospital setting, remains less clear.
Domoic acid is a glutaminergic neurotoxin produced by marine algae such as Pseudo-nitzschia australis. California sea lions (Zalophus californianus) ingest the toxin when foraging on planktivorous fish. Adult females comprise 60% of stranded animals admitted for rehabilitation due to acute domoic toxicosis and commonly suffer from reproductive failure, including abortions premature live births. has been shown cross placenta exposing fetus toxin. To determine whether was playing role in...