A5024590891- Virology and Viral Diseases
- Respiratory viral infections research
- Animal Virus Infections Studies
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Cancer-related molecular mechanisms research
- Syphilis Diagnosis and Treatment
- Immune responses and vaccinations
- Rabies epidemiology and control
- Bacteriophages and microbial interactions
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Polyomavirus and related diseases
- Ion Channels and Receptors
- HIV Research and Treatment
- Pediatric health and respiratory diseases
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- Alzheimer's disease research and treatments
- Vector-Borne Animal Diseases
Queen's University Belfast
2011-2025
Agri Food and Biosciences Institute
2017-2025
Embry–Riddle Aeronautical University
2024
National University of Ireland
1985-2015
Institute of Infection and Immunity
2006-2011
Royal Victoria Hospital
1995-2007
University of Ulster
1995-2007
Belfast City Hospital
1999
Queens University
1989-1998
Royal Victoria Hospital
1993
Transmission electron microscopy was used to examine the microvasculature of perfusion-fixed tissues from Crohn's disease and control patients. Paramyxovirus-like particles, inclusions consisting condensations nucleocapsid, in giant cells endothelium at foci vascular injury were identified all 9 Tissues patients with also examined by either situ hybridisation (n = 10) or immunohistochemistry 15), compared inflammatory noninflammatory controls 22). Hybridisation for measles virus N-protein...
<h3>Background</h3> The mechanism underlying respiratory virus-induced cough hypersensitivity is unknown. Upregulation of airway neuronal receptors responsible for sensing physical and chemical stimuli one possibility, the transient receptor potential (TRP) channel family are candidates. We have used an in vitro model sensory neurons human rhinovirus (HRV-16) to study effect virus infection on TRP expression. <h3>Methods</h3> IMR-32 neuroblastoma cells were differentiated culture express...
Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), cation channel, Subfamily A, Member (TRPA1) and acid sensing ion channel 3 (ASIC3). Respiratory viruses, such as respiratory syncytial virus (RSV) measles (MV) may interact directly and/or indirectly with these receptors on sensory nerves epithelial cells the airways. We used vitro models of neurones (SHSY5Y or differentiated IMR-32 cells) human bronchial epithelium (BEAS-2B well primary...
Abstract Paget's disease of bone is a common characterized by increased and disorganized remodeling at focal sites throughout the skeleton. The etiology unresolved. A persistent viral infection has long been suggested to cause disease. Antigen and/or nucleic acid sequences paramyxoviruses (in particular measles virus [MV], canine distemper [CDV], respiratory syncytial [RSV]) have reported in pagetic number groups; however, others unable confirm this so far no isolated from patients. Here, we...
Abstract Climate change-driven alterations in Arctic environments can influence habitat availability, species distributions and interactions, the breeding, foraging, health of marine mammals. Phocine distemper virus (PDV), which has caused extensive mortality Atlantic seals, was confirmed sea otters North Pacific Ocean 2004, raising question whether reductions ice could increase contact between sub-Arctic mammals lead to viral transmission across Ocean. Using data on PDV exposure infection...
There is strong evidence that SARS-CoV-2 spread predominantly by airborne transmission, with high viral loads released into the air as respiratory droplets and aerosols from infected subject. The persistence of in diverse indoor environments reinforces urgent need to supplement distancing PPE based approaches effective engineering measures for microbial decontamination – thereby addressing significant risk posed aerosols. We hypothesized a portable, single-pass UVC treatment device (air flow...
SUMMARY In situ hybridization studies have been carried out on brain samples from eight cases of multiple sclerosis (MS) and 56 non-neurological neurological controls, using single-stranded 35S-labelled RNA probes prepared against genomic sequences measles virus, canine distemper rubella virus simian 5. Foci were found the nucleocapsid protein (N), phosphoprotein fusion gene in two MS cases, also one control, a case disseminated cytomegalovirus infection with spinal cord necrosis. This...
To assess the association of vaginal commensal and low-grade pathogenic bacteria including Ureaplasma parvum, urealyticum, Mycoplasma hominis, genitalium, Group B streptococcus (GBS), Gardnerella vaginalis, in women who delivered preterm at less than 37-week gestation presence or absence inflammation chorioamnionitic membranes.A case control study involving before with without membranes. A total 57 placental samples were histologically examined for polymorphonuclear leukocyte infiltration...
ABSTRACT Immune suppression associated with morbillivirus infections may influence the mortality rate by allowing secondary bacterial that are lethal to host flourish. Using an in vitro proliferation assay, we have shown all members of genus Morbillivirus inhibit a human B-lymphoblast cell line (BJAB). Proliferation freshly isolated, stimulated bovine and caprine peripheral blood lymphocytes is also inhibited UV-inactivated rinderpest (RPV) peste-des-petits ruminants viruses. As for measles...
Abstract Bovine Respiratory Disease (BRD) is the leading cause of mortality in calves. The objective this study was to examine response host’s bronchial lymph node transcriptome Syncytial Virus (BRSV) a controlled viral challenge. Holstein-Friesian calves were either inoculated with virus (10 3.5 TCID 50 /ml × 15 ml) (n = 12) or mock challenged phosphate buffered saline 6). Clinical signs scored daily and blood collected for haematology counts, until euthanasia at day 7 post-challenge. RNA...
Fasciolosis, a global parasitic disease of agricultural livestock, is caused by the liver fluke Fasciola hepatica. Management and strategic control fasciolosis on farms depends early assessment extent so that measures can be implemented quickly. Traditionally, this has relied detection eggs in faeces animals, laborious method lacks sensitivity, especially for sub-clinical infections, identifies chronic infections only. Enzyme linked immunosorbent assays (ELISA) offer quicker more sensitive...
Bovine herpesvirus 1 (BoHV-1), is associated with several clinical syndromes in cattle, among which bovine respiratory disease (BRD) of particular significance. Despite the importance disease, there a lack information on molecular response to infection via experimental challenge BoHV-1. The objective this study was investigate whole-blood transcriptome dairy calves experimentally challenged A secondary compare gene expression results between two separate BRD pathogens using data from similar...
Bovine alphaherpesvirus one (BoHV-1) is a primary cause of bovine respiratory disease (BRD), and leading morbidity mortality in cattle. The transcriptomic responses key immune associated tissues dairy calves following experimental challenge with BoHV-1 are unknown. Thus, the study objective was to examine gene expression profiles multiple tissue types from an infectious BoHV-1. Holstein-Friesian bull (mean age ± SD 149.2 days 23.8; mean weight 174.6 kg 21.3 were challenged either inoculate...
ABSTRACT Molecular determinants of neuropathogenesis have been shown to be present in the hemagglutinin (H) protein measles virus (MV). An H gene insertion vector has generated from Edmonston B vaccine full-length infectious clone MV. Using this vector, it is possible insert complete open reading frames into parental (Edtag) background. The a rodent brain-adapted MV strain (CAM/RB) was inserted and recombinant (EdtagCAMH) rescued by using modified vaccinia which expresses T7 RNA polymerase...