A5058694870- Electronic Health Records Systems
- Emergency and Acute Care Studies
- Geriatric Care and Nursing Homes
- Patient Safety and Medication Errors
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Family and Patient Care in Intensive Care Units
- Growth Hormone and Insulin-like Growth Factors
- Cancer Cells and Metastasis
- Patient-Provider Communication in Healthcare
- Patient Satisfaction in Healthcare
- Heart Failure Treatment and Management
- Pharmaceutical Practices and Patient Outcomes
- Hospital Admissions and Outcomes
- Primary Care and Health Outcomes
- Interprofessional Education and Collaboration
- Healthcare Technology and Patient Monitoring
- Healthcare Systems and Technology
- Cancer Research and Treatments
- Palliative Care and End-of-Life Issues
- Global Health Workforce Issues
- COVID-19 and healthcare impacts
- Cytokine Signaling Pathways and Interactions
- Alcoholism and Thiamine Deficiency
- Telomeres, Telomerase, and Senescence
Brigham and Women's Hospital
2015-2024
Harvard University
2016-2023
Woman's Hospital
2023
Massachusetts General Hospital
2021
Boston College
2021
Cancer Research Institute
2004-2012
University of Pennsylvania
2001-2012
Stony Brook University
1995-1998
State University of New York
1998
North Shore University Hospital
1998
Background: Racial inequities for patients with heart failure (HF) have been widely documented. HF who receive cardiology care during a hospital admission better outcomes. It is unknown whether there are differences in to or general medicine service by race. This study examined the relationship between race and service, its effect on 30-day readmission mortality Methods: We performed retrospective cohort from September 2008 November 2017 at single large urban academic referral center of all...
Normal developmental events such as puberty, pregnancy, and parity influence the susceptibility of mammary gland to tumorigenesis in both humans rodent model systems. Unfortunately, constitutive transgenic mouse models that rely on mammary-specific promoters control transgene expression have limited utility for studying effect breast cancer risk since hormonal signals governing these also markedly levels. A novel system is described uses MMTV-LTR drive reverse tetracycline-dependent...
Abstract Objective We deployed a Remote Patient Monitoring (RPM) program to monitor patients with coronavirus disease 2019 (COVID-19) upon hospital discharge. describe the patient characteristics, and clinical outcomes of in our RPM program. Methods enrolled COVID-19 being discharged home from hospital. Enrolled had an app, were provided pulse oximeter thermometer. Patients self-reported symptoms, O2 saturation, temperature daily. Abnormal symptoms or vital signs flagged assessed by pool...
Extrapituitary prolactin (Prl) is produced in humans and rodents; however, little known about its vivo regulation or physiological function. We now report that autocrine required for terminal mammary epithelial differentiation during pregnancy production regulated by the Pten–PI3K–Akt pathway. Conditional activation of PI3K–Akt pathway glands virgin mice either Akt1 expression Pten deletion rapidly induced accompanied synthesis milk despite absence lobuloalveolar development. Surprisingly,...
Abstract Background Preventable adverse events continue to be a threat hospitalized patients. Clinical decision support in the form of dashboards may improve compliance with evidence-based safety practices. However, limited research describes providers' experiences integrated into vendor electronic health record (EHR) systems. Objective This study was aimed describe use and perceived usability Patient Safety Dashboard discuss barriers facilitators implementation. Methods The implemented...
<h3>Importance</h3> Home hospital care is the substitutive provision of home-based acute services usually associated with a traditional inpatient hospital. Many home models require physician to see patients at daily, which may hinder scalability. Whether remote visits can safely substitute for most in-home unknown. <h3>Objective</h3> To compare and care. <h3>Design, Setting, Participants</h3> This randomized clinical trial assessed 172 adult an academic medical center community who required...
Poor discharge preparation during hospitalization may lead to adverse events after discharge. Checklists and videos that systematically engage patients in preparing for have the potential improve safety, especially when integrated into clinician workflow via electronic health record (EHR).
We have previously shown that c-MYC-induced mammary tumorigenesis in mice proceeds via a preferred secondary pathway involving spontaneous activating mutations Kras2 (C. M. D'Cruz, E. J. Gunther, R. B. Boxer, L. Hartman, Sintasath, S. Moody, D. Cox, I. Ha, G. K. Belka, A. Golant, Cardiff, and Chodosh, Nat. Med. 7:235-239, 2001). In contrast, we now demonstrate Wnt1-induced preferentially activates Hras1. addition, find expression of oncogenic forms Hras1 from their endogenous promoters has...
The Akt pathway plays a central role in regulating cell survival, proliferation and metabolism, is one of the most commonly activated pathways human cancer. A for epithelial differentiation, however, has not been established. We previously reported that mice lacking Akt1, but Akt2, exhibit pronounced metabolic defect during late pregnancy lactation results from failure to upregulate Glut1 as well several lipid synthetic enzymes. Despite this defect, both Akt1-deficient Akt2-deficient normal...
Objectives To assess the therapeutic efficacy of chloroquine (CQ) treatment against uncomplicated Plasmodium falciparum infections in a tribal population central India (Madhya Pradesh) and to investigate prevalence mutant P. chloroquine-resistant transporter (pfcrt) gene parasite population. Methods Clinical parasitological response was determined by in-vivo testing. For molecular testing, DNA extracted from blood samples used amplify sequence parts pfcrt (44–177 codons), MSP1 (block 2) MSP2...
BACKGROUND Dispersion of inpatient care teams across different medical units impedes effective team communication, potentially leading to adverse events (AEs). OBJECTIVE To regionalize 3 general nursing and examine the association with communication preventable AEs. DESIGN Pre‐post cohort analysis. SETTING A 700‐bed academic center. PATIENTS General medicine patients on any participating before after implementation regionalized care. INTERVENTION Regionalizing physician corresponding units....
Abstract Objective Low health literacy is common, leading to patient vulnerability during hospital discharge, when patients rely on written instructions. We aimed examine the impact of use electronic, patient-friendly, templated discharge instructions readability provided at discharge. Materials and Methods performed a retrospective cohort study 233 discharged from large tertiary care their homes following implementation web-based “discharge module,” which included optional...
Attending rounds at academic medical centers are often disconnected from patients and team members who not physicians. Regionalization of care teams may facilitate bedside rounding more frequent interactions among doctors, nurses, patients.We used time-motion analysis to investigate how regionalization encouragement affect participants on time.We pre-post study the effects redesign teams' daily a general medicine service an center.Four were evaluated before intervention 5 afterward.General...
BACKGROUND: Overall outcomes and the escalation rate for home hospital admissions heart failure (HF) are not known. We report overall outcomes, predict escalation, describe care provided after among patients admitted to HF. METHODS: Our retrospective analysis included all HF 2 programs in Massachusetts between February 2020 October 2022. Escalation of was defined as transfer an inpatient setting (emergency department, medical unit) at least 1 overnight stay. Unexpected mortality excluding...
BACKGROUND Attending rounds at academic medical centers are often disconnected from patients and team members who not physicians. Regionalization of care teams may facilitate bedside rounding more frequent interactions among doctors, nurses, patients. OBJECTIVE We used time–motion analysis to investigate how regionalization encouragement affect participants on time. DESIGN AND SETTING pre–post study the effects redesign teams' daily a general medicine service an center. PARTICIPANTS Four...
Over the last century, attending rounds have shifted away from bedside. Despite evidence for greater patient satisfaction rates and improved nursing perception of teamwork with bedside presentations, residents physicians are apprehensive approach. There is lack data to guide rounding practices within neurology, therefore, optimal methods remain unclear. The objective this study was compare hallway on an academic neurology inpatient service assess efficiency, trainee education, among patients...
Abstract Objective To investigate the effects of adjusting default order set settings on telemetry usage. Materials and Methods We performed a retrospective, controlled, before-after study patients admitted to house staff medicine service at an academic medical center examining effect changing whether admission was pre-selected or not. Telemetry orders subsequent for were monitored pre- post-change. Two other sets that had no change in their used as controls. Results Between January 1, 2017...