A5020774547- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoparticle-Based Drug Delivery
- Chaos control and synchronization
- Asymmetric Synthesis and Catalysis
- Mathematical Dynamics and Fractals
- Liver Disease Diagnosis and Treatment
- Chaos-based Image/Signal Encryption
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Radar Systems and Signal Processing
- Lung Cancer Research Studies
Heilongjiang University
2024
First Affiliated Hospital Zhejiang University
2008-2022
Zhejiang University
2015-2020
Hangzhou Xixi hospital
2018-2020
Second Affiliated Hospital of Zhejiang University
2018
State Council of the People's Republic of China
2018
National University of Defense Technology
2017
We herein propose a bioengineering approach where bacterial outer membrane vesicles (OMVs) were coated on drug-loaded polymeric micelles to generate an innovative nanomedicine for effective cancer immunotherapy and metastasis prevention. Whereas OMVs could activate the host immune response immunotherapy, loaded drug within would exert both chemotherapeutic immunomodulatory roles sensitize cells cytotoxic T lymphocytes (CTLs) kill directly. demonstrated that systemic injection of such...
Abstract Cytomembrane‐derived nanoplatforms are an effective biomimetic strategy in cancer therapy. To improve their functionality and expandability for enhanced vaccination, a eukaryotic–prokaryotic vesicle (EPV) nanoplatform is designed constructed by fusing melanoma cytomembrane vesicles (CMVs) attenuated Salmonella outer membrane (OMVs). Inheriting the virtues of parent components, EPV integrates antigens with natural adjuvants robust immunotherapy can be readily functionalized...
Enantioselective synthesis of fully substituted allenes has been a challenge due to the non-rigid nature axial chirality, which spreads over three carbon atoms. Here we show commercially available simple Rh complex may catalyse CMD (concerted metalation/deprotonation)-based reaction readily arenes with sterically congested tertiary propargylic carbonates at ambient temperature affording allenes. It is confirmed that excellent designed regioselectivity for C-C triple bond insertion induced by...
Abstract Construction of two vicinal all-carbon quaternary carbon centres is great importance due to the common presence such units in natural and unnatural molecules with attractive functions. However, it remains a significant challenge. Here, we have developed palladium-catalysed general coupling for efficient connection tertiary atoms: Specifically, propargylic carbonate has been treated fully loaded soft functionalized nucleophile connect atoms simple palladium catalyst. It observed that...
Liver cancer is the sixth most commonly diagnosed and fourth leading cause of death worldwide. Socioeconomic development, indicated by Human Development Index (HDI), closely interconnected with public health. But manner in which social development medical advances influenced liver patients past decade still unknown.To investigate influence HDI on clinical outcomes for existing from 2008 to 2018.The values were obtained United Nations Programme, age-standardized incidence mortality rates...
miRNA cocktail therapy based on pH-responsive nanoparticles featuring PEG detachment and size transformation is a potential strategy for HCC treatment.
A biodegradable, oncosensitive, megamer-based delivery system has been developed for microenvironment-activatable miRNA therapy.
Palladium-catalyzed tandem reactions of 2,7-alkadiynylic carbonates with allenes bearing a carbon nucleophile such as malonate and bis(phenylsulfonyl)methane for the efficient syntheses fused tricycles, 3,5,6,7-tetrahydro-1H-indeno[5,6-c]furan, 1,2,3,5,6,7-hexahydrocyclopenta[f]isoindole, 1,2,3,5,6,7-hexahydro-s-indacene derivatives, have been reported. The reaction forms two five-membered rings one benzene ring fusing them in middle.
A palladium-catalyzed highly regio- and chemo-selective cyclization to construct 1,3-dihydroisobenzofuran isoindoline derivatives under mild conditions has been developed.
Abstract The palladium‐catalyzed tandem reactions of 2,7‐alkadiynylic carbonates with 2,3‐allenyl sulfamides for the syntheses fused tricycles such as 1,3,6,7,8,9‐hexahydrofuro[3,4 ‐h ]isoquinoline, 2,3,6,7,8,9‐hexahydro‐1 H ‐pyrrolo[3,4 and 2,3,4,7,8,9‐hexahydro‐1 ‐cyclopenta[ h ]isoquinoline derivatives have been developed. A mechanism has proposed based on isolation a by‐product. magnified image
Based on Dechirping algorithm and uniform circle array (UCA), a new 2-D direction of arrival (DOA) estimation linear frequency modulation (LFM) signals is proposed in this paper.The uses the thought regards signal to be estimated which received by reference sensor as proceeds difference treatment with each sensor.So becomes single-frequency sensor.Then we transform an isolated impulse through Fourier (FFT) construct data model based prominent parts impulse.Finally, respectively use multiple...
Abstract Chaotic systems are widely used in secure communication due to their sensitivity initial values, unpredictability, and complex motion trajectories. In this paper, we study the encryption method of chaotic synchronization introduce a scaling factor based on traditional feedback control achieve more accurate projection synchronization. The effectiveness robustness verified through theoretical proofs numerical simulations. A masked speech system utilizing bit similarity is designed;...
Abstract A palladium‐catalyzed highly E ‐selective triple cyclization of 2,7‐alkadiynylic carbonates with 2‐butyne‐1,4‐diol or 2‐butyne‐1,4‐disulfonamides to construct different tricycles such as 6,8‐dihydrobenzo[1,2‐c:3,4‐c′]difuran‐1(3 H )‐one and 1,3,6,7‐tetrahydro‐8 ‐furo[3,4‐e]isoindol‐8‐one derivatives has been reported. The alkene group produced the nucleophilic unit kept in product provide further opportunity more complicated polycycles. control experiments showed that reaction...
Abstract The reaction forms attractive tricyclic scaffolds consisting of two benzene fused five‐membered rings.