A5101932605- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- Lung Cancer Research Studies
- Medical Research and Treatments
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Cervical Cancer and HPV Research
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Heat shock proteins research
- Biosimilars and Bioanalytical Methods
- Viral Infections and Immunology Research
- Cancer Mechanisms and Therapy
- Respiratory viral infections research
- Chromatin Remodeling and Cancer
- Cancer-related gene regulation
- Oral microbiology and periodontitis research
- Ectopic Pregnancy Diagnosis and Management
- Oral health in cancer treatment
- Pain Management and Opioid Use
- Chemotherapy-induced organ toxicity mitigation
Tianjin University of Science and Technology
2024-2025
Chongqing Medical University
2025
Inner Mongolia People's Hospital
2011-2023
Hebei Medical University
2019
Xingtai People's Hospital
2019
Xingtai Medical College
2019
Sun Yat-sen University
2019
Sun Yat-sen University Cancer Center
2019
Pudong New Area People's Hospital
2013
Dongguan People’s Hospital
2012
Ethnopharmacological relevanceIn the clinical practice of traditional Chinese medicine, concept toxic heat and blood stasis syndrome (THBSS) is commonly observed in many critical diseases. Although herbal medicine Paeoniae Radix Rubra (PRR) has been employed for treating various diseases associated with THBSS, difference pharmacokinetic characteristics its bioactive constituents between such pathological state normal remains unknown.Aim studyTo elucidate profiles six from PRR following oral...
Abstract Background Central nervous system (CNS) metastases in patients with ALK-positive non-small cell lung cancer (NSCLC) are a cause of substantial morbidity and mortality. Although alectinib had demonstrated promising intracranial efficacy several clinical trials, data were limited on its CNS activity real-world settings. Methods In this retrospective study, NSCLC brain (BM) or leptomeningeal (LM) from six hospitals China divided into three cohorts based the treatment history before...
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and concurrent mutations have a poor prognosis. This study aimed to examine anlotinib plus icotinib as first-line treatment option for advanced NSCLC carrying EGFR or without mutations.This phase 2, single-arm, multicenter trial (ClinicalTrials.gov NCT03736837) was performed at five hospitals in China from December 2018 November 2020. Non-squamous cases EGFR-sensitizing were treated icotinib....
To study the platelet adhesion and aggregation behaviour of late pregnancy women under arterial shear rate using microfluidic chip technology evaluate risk thrombosis in pregnancy. We included pregnant who were registered obstetrics department our hospital between January 2021 October 2022 underwent regular prenatal examinations. Blood samples collected at 32-35 weeks gestation for routine blood tests progesterone, oestradiol, function. A was used to construct an vitro stenosis vascular...
In this study, a Bacillus velezensis SDU strain capable of producing poly-γ-glutamate (γ-PGA) was newly identified from the rhizosphere soil Baimiao taro. The is glutamate-independent and can produce polyglutamic acid in culture medium completely free glutamate. hydrolyzed product produced D-glutamic acid. molecular weight γ-PGA, estimated via Mark–Houwink equation, 1390 kDa. Furthermore, measured by Waters gel permeation chromatography with multi-angle laser light scattering (GPC–MALLS)...
Background: Bevacizumab is a monoclonal antibody (mAb) against vascular endothelial growth factor (VEGF) and used for treatments of various cancers. Due to the high costs bevacizumab treatments, biosimilar provides an affordable alternative therapy cancer patients. Methods: In this randomized, double-blind, multicenter, phase 3 study, locally advanced, metastatic or recurrent non-squamous non-small cell lung (NSCLC) patients with wild-type epidermal receptor were enrolled randomized (1:1)...
Abstract Purpose: Our primary purpose is to explore safety and efficacy of high-dose icotinib in comparison with routine-dose patients non–small cell lung cancer (NSCLC) harboring 21-L858R mutation. Patients Methods: treatment-naïve, EGFR-mutant (21-L858R or exon 19 deletion at 2:1) NSCLC were enrolled. mutation randomized receive (125 mg, thrice daily; L858R-RD) (250 L858R-HD), whereas received only (19-Del-RD) until progression, death, unacceptable toxicity. The endpoint was median...
Aberrant upregulation of hepatic lipogenesis induced by chronic and excessive alcohol consumption is a critical driver the progression alcohol-associated liver disease (ALD), however, no effective approaches inhibiting are currently available for treating ALD patients. Moreover, little known about whether how nonethanol ingredients in alcoholic beverages regulate pathogenesis ALD. Here discovery small molecule that activates production secretion fibroblast growth factor 21 (FGF21) reported....
Heat shock protein 90 (HSP90) has been reported to promote the growth and inhibit apoptosis of hepatocellular carcinoma (HCC) cells. However, underlying mechanisms are not fully understood. Immunostaining tissue array demonstrated that HSP90 was upregulated in HCC clinical samples associated with features. interacted 3‑hydroxy‑3‑methylglutaryl‑CoA reductase (HMGCR), rate‑limiting enzyme mevalonate pathway, immunoprecipitation assay regulated its expression level by inhibiting degradation. In...
Abstract Background Pain is a fearful yet common symptom among lung cancer patients. This multicenter, cross‐sectional study was conducted to examine the current status of pain prevalence and management in patients northern China. Methods A total 18 hospitals across China were selected. Patients with primary who visited outpatient clinic or admitted wards on preplanned day invited complete questionnaire. Meanwhile, physicians had experience treating also surveyed. Results 533 197 provided...
Abstract The role of long noncoding RNA maternally expressed gene 3 (MEG3) in lung adenocarcinoma has not been explored entirely. In this study, it was demonstrated that the expression MEG3 enhanced tissues from TCGA database and some specific cell lines, while survival analysis showed patients with higher levels had lower probabilities, which suggested might serve as a promoter. addition, results overexpression could promote proliferation invasion cells. Furthermore, increased result...
9573 Background: Anti-angiogenic monoclonal antibodies plus EGFR TKIs have previously shown to prolong PFS in patients with EGFR-mutated NSCLC (JO25567 and NEJ026). Unlike bevacizumab, anlotinib is more convenient orally administered can inhibit targets. Monotherapy using has significantly prolonged median OS compared the placebo values for third-line treatment or beyond advanced NSCLC. We conducted a study investigate activity of anlotinb combined icotinib, an oral TKI. Methods: This...
Abstract Background There is limited data on the clinical outcome, long‐term survival and tolerability of sequential therapy first‐line crizotinib followed by alectinib in a real‐world setting for Chinese patients with advanced ALK+ NSCLC. Methods The medical records who received (no intermittent systemic was allowed between two ALK‐TKIs) were collected from six centers China. Combined time treatment to failure (C‐TTF) defined as period start complete discontinuation due any cause. Results A...
Cervical carcinoma high-expressed long non-coding RNA 1 (CCHE1) has been demonstrated to promote several different types of cancer; however, the involvement CCHE1 in other cancer remains unknown. In present study, expression levels and interleukin (IL)-17A were increased plasma patients with metastatic non-metastatic colon adenocarcinoma (MC NMC, respectively) compared healthy controls. There was no significant difference IL-17A MC NMC. The positively associated primary tumor diameter. A...
9095 Background: IBI305 is a recombinant humanized anti-VEGF monoclonal antibody, biosimilar candidate to bevacizumab in analytical and functional comparisons. Pharmacokinetic similarity has been demonstrated healthy males. Here we present primary efficacy safety results from phase 3 comparative study non-small cell lung cancer (NSCLC). Methods: In this double-blind, active-controlled study, subjects with advanced non-squamous NSCLC on first-line treatment carboplatin paclitaxel were...
Drug resistance is one of the major obstacles for chemotherapy and targeted therapy in lung cancer with complex mechanisms. The researches have demonstrated that epigenetic changes are closely related to drug tumor. DNA methylation an important modification. In this paper, relationships between hMLH1 promoter aberrant platinum-resistance, DAPK EGFR-TKI will be briefly reviewed. Key words: Lung neoplasms; hMLH1; DAPK; DNA methylation; Drug resistance, neoplasms