A5077314509- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Eosinophilic Esophagitis
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- Galectins and Cancer Biology
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hemostasis and retained surgical items
- Biliary and Gastrointestinal Fistulas
- Inflammatory mediators and NSAID effects
- Neuroendocrine Tumor Research Advances
An-Nan Hospital
2019-2025
China Medical University
2019-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2024
National Kaohsiung University of Science and Technology
2023
China Medical University
2022
National Yang Ming Chiao Tung University
2011-2020
Kaohsiung Veterans General Hospital
2011-2020
National Taipei University
2012-2018
National Yang Ming University Hospital
2008-2017
Baylor College of Medicine
2003-2015
Abstract Background: Ten‐day sequential therapy with a proton pump inhibitor (PPI) and amoxicillin followed by PPI, clarithromycin, an imidazole typically achieves Helicobacter pylori eradication rates of 90–94% (Grade B success). Aims: We tested whether prolonging treatment continuing throughout the 14‐day period would produce ≥95% result. Methods: This was multicenter pilot study in which H. ‐infected patients received sequential–concomitant hybrid (esomeprazole for 7 days esomeprazole,...
Objective. In patients with cirrhosis and spontaneous bacterial peritonitis (SBP), the use of intravenous albumin has been shown to prevent deterioration renal function decrease mortality rate, but mechanisms remain unclear. The purpose this study was characterize action focus on endotoxin cytokines. Material methods. Thirty SBP were divided into two groups. Group 1 received antibiotics infusion (20% 50 cc every day for 3 days) 2 antibiotic treatment only. Twenty-four cirrhotic sterile...
This prospective cohort study investigated the impact of Helicobacter pylori infection on development various gastric malignancies.We prospectively followed up 1,225 dyspeptic Taiwanese who had nonulcer dyspepsia, ulcers, or duodenal ulcers at enrollment. Among them, 618 (50.4%) H. and 607 (49.6%) did not. Patients underwent endoscopy enrollment 1- to 3-yr intervals thereafter.During a mean follow-up 6.3 yr, adenocarcinoma developed in 7 pylori-infected patients, but none uninfected patients...
Both medical therapy and endoscopic variceal ligation (EVL) have proven to be comparable in the prevention of rebleeding. However, long-term results are still lacking. Our previous study enrolled 121 patients with history esophageal bleeding randomized receive EVL (EVL group, 60 patients) or drug therapy, nadolol plus isosorbide-5-mononitrate (N+I) (N+I 61 prevent The group received regularly until obliteration. N+I during period. Patients were followed for up 8 years. After a median...
Abstract Background Bismuth quadruple therapy is the treatment of choice for first‐line Helicobacter pylori infection in areas high clarithromycin resistance. Currently, impact promising on gut microbiota remains unclear. Aim To investigate short‐term and long‐term impacts bismuth microbiota. Methods Adult patients with H. ‐related gastritis were treated 14‐day therapy. Fecal samples collected before at week 2, 8, 48. Nucleic acid extraction from fecal was performed. The V3‐V4 region...
Abstract Background Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in prevalence and antimicrobial resistance H. , availability medications endoscopy. Thus, nationwide or regional needed to improve control infection gastric cancer. Materials Methods This statement Taiwan has three major sections: (1) optimal diagnosis indications; (2) current treatment strategies; (3)...
ABSTRACT With the rising prevalence of antimicrobial resistance, failure rate standard triple therapy for Helicobacter pylori infection is increasing. Sequential and concomitant have been recommended to replace H. eradication in regions with high clarithromycin resistance. The aim this prospective, randomized, controlled study was simultaneously assess efficacies 10-day sequential 7-day therapies versus a treating infection. Consecutive -infected subjects were randomly assigned...
Abstract TNF-related apoptosis-inducing ligand (TRAIL, also called Apo2L), a novel member of TNF superfamily, induces apoptosis in transformed cell lines diverse origin. TRAIL is expressed most the cells, and expression up-regulated activated T cells. Four receptors for have been identified, there complex interplay between vivo. The actual biological function TRAIL/TRAIL receptor still not clear. Growing evidence has demonstrated that members superfamily transduce signals after engagement...
Endoscopic variceal ligation (EVL) is a new technique designed to manage esophageal varices. The effect of sclerotherapy following repeated banding remains unknown. Seventy-two patients with history bleeding received regular EVL until disappearance or left residual small Subsequently, were randomized receive (Group 1, 37 patients) serve as control 2, 35 patients). Group 1 one two sessions low-dose achieve complete disappearance. After mean follow-up 2 years, 4 months, recurrent varices...
Lethal pancreatitis has been reported after treatment for common bile duct stones using small endoscopic papillary balloon dilation.We retrospectively evaluated the safety and efficacy of large dilation alone without use sphincterotomy in Kaohsiung Veterans General Hospital. Success rate stone clearance, procedure-related adverse events incidents, frequency mechanical lithotripsy use, recurrent were recorded.A total 247 patients reviewed current study. The mean age was 71.2 years. Most them...
To investigate the prevalence and risk factors of asymptomatic colorectal diverticulosis in Taiwanese general population.From January 2009 to December 2011, consecutive subjects undergoing a health check-up were evaluated by colonoscopy. The was assessed, medical history demographic data obtained from each subject. Logistic regression analysis conducted search diverticulosis.Of 1899 subjects, 13.5%. On univariate logistic analysis, age over 60 years old, male, adenomatous polyp, current...
Aspirin increases the risk of gastrointestinal bleeding.To investigate lower bleeding (LGIB) in aspirin users.Low-dose (75-325 mg daily) users and controls matched by age, gender enrollment time a 1:5 ratio were selected from 1 million randomly sampled subjects National Health Insurance Research Database Taiwan. Cox proportional hazard regression models developed to evaluate predictors LGIB with adjustments for gender, comorbidities including coronary artery disease, ischaemic stroke,...
Abstract Background and Aims Anti‐ Helicobacter pylori therapy may lead to the growth of pathogenic or antibiotic‐resistant bacteria in gut. The study aimed investigate short‐term long‐term impacts H. eradication with reverse hybrid on components macrolide resistance gut microbiota. Methods ‐related gastritis patients were administered a 14‐day therapy. Fecal samples collected before treatment at end week 2, 8, 48. V3–V4 region bacterial 16S rRNA gene fecal specimens was amplified by...
INTRODUCTION: The study aimed to compare the efficacies and safety of 14-day hybrid therapy, high-dose dual 10-day bismuth quadruple therapy in first-line treatment Helicobacter pylori infections. METHODS: In this multicenter, open-label, randomized trial, we recruited adult H. -infected patients from 9 centers Taiwan. Subjects were randomly assigned (1:1:1) or therapy. Eradication status was determined by 13 C-urea breath test. primary outcome eradication rate assessed intention-to-treat...
Helicobacter pylori (H. pylori) infection is the principal cause of chronic gastritis, gastric ulcers, duodenal and cancer. In clinical practice, diagnosis H. by a gastroenterologists' impression endoscopic images inaccurate cannot be used for management gastrointestinal diseases. The aim this study was to develop an artificial intelligence classification system pre-processing machine learning methods. Endoscopic body antrum from 302 patients receiving endoscopy with confirmation status...
Background: Although the eradication of Helicobacter pylori infection benefits patients with gastric or duodenal ulcers, value eradicating in functional dyspepsia (FD) remains controversial. Aims: To determine whether H. can prevent subsequent development ulcers relieve symptoms patients. Methods: In a double‐blind, placebo‐controlled trial, 161 infected who had were randomly assigned to 7 days treatment lansoprazole‐based triple therapy placebo and then followed for 1 year. The main outcome...
From September 1991 to December 1992, a prospective study was conducted determine the risk factors and residual of rebleeding, evolutionary endoscopic changes in peptic ulcers that rebled. Emergency endoscopies were performed on 452 patients with haematemesis or melaena, both within 24 hours admission. If lesions actively bleeding, then treated injection sclerotherapy. A multivariate analysis clinical, laboratory, variables 204 ulcer bleeding showed hypovolaemic shock, non-bleeding visible...