A5008190101- Adipose Tissue and Metabolism
- Bone Tissue Engineering Materials
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Wound Healing and Treatments
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Radioactive element chemistry and processing
- Fibroblast Growth Factor Research
- Electrospun Nanofibers in Biomedical Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Biochemical effects in animals
- Bone and Dental Protein Studies
- Parkinson's Disease Mechanisms and Treatments
- Wnt/β-catenin signaling in development and cancer
- Microbial metabolism and enzyme function
- Planarian Biology and Electrostimulation
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
Chongqing Medical University
2017-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2024
Molecular Oncology (United States)
2024
State Key Laboratory of Molecular Oncology
2024
National Clinical Research
2024
Qingdao University
2016-2017
CAE (Canada)
2004
Army Medical University
2004
Abstract Obesity is associated with biological dysfunction in skeletal muscle. As a condition of obesity accompanied by muscle mass loss and physical dysfunction, sarcopenic (SO) has become novel public health problem. Human fibroblast growth factor 19 (FGF19) plays therapeutic role metabolic diseases. However, the protective effects FGF19 on SO are still not completely understood. Our results showed that administration improved grip strength young aged mice fed high‐fat diet (HFD)....
Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted...
Abstract Age-related loss of skeletal muscle mass and function, termed sarcopenia, could impair the quality life in elderly. The mechanisms involved aging are intricate largely unknown. However, more evidence demonstrated that mitochondrial dysfunction apoptosis also play an important role aging. Recent studies have shown calcium uniporter (MCU)-mediated affects function by affecting function. During aging, we observed downregulated expression uptake family member3 (MICU3) muscle, a...
Abstract Aging‐related sarcopenia is currently the most common sarcopenia. The main manifestations are skeletal muscle atrophy, replacement of fibers with fat and fibrous tissue. Excessive fibrosis can impair regeneration function. Lysyl oxidase‐like 2 (LOXL2) has previously been reported to be involved in development various tissue fibrosis. Here, we investigated effects LOXL2 inhibitor on D‐galactose (D‐gal)‐induced fibroblast cells mice. Our molecular physiological studies show that...
The bio-inertness of titanium (Ti) and the accompanying severe inflammation can extremely inhibit coupled osteogenesis-angiogenesis regulation result in undesirable osseointegration peri-implant during implantation process. Herein, three types TiO2 nanotubes (TNT) were prepared on native Ti substrates using anodic oxidation approach, including TNT with a diameter 30 nm (TNT-30), 70 (TNT-70), 110 (TNT-110). Among four substrates, TNT-70 was most prominent to induce differentiation macrophages...
Age-related sarcopenia, characterized by reduced skeletal muscle mass and function, significantly affects the health of elderly individuals. Oxidative stress plays a crucial role in development sarcopenia. Tripartite motif containing 16 (TRIM16) is implicated orchestrating antioxidant responses to mitigate oxidative stress, yet its regulatory remains unclear. This study aims elucidate impact TRIM16 on enhancing response through SIRT-1, consequently mitigating age-related ameliorating atrophy.
Accelerated population ageing has brought a great burden to the development of society. Repairing senile osteoporosis fractures is challenge, but desirable way address this issue by developing multifunctional titanium(Ti) implants with antiaging and pro-osteogenic effects. Herein, endow TI substrate an effect for enhanced bone formation, exercise-induced myokine(irisin) was loaded on titanium dioxide nanotubes(TNTs) then multilayered structure composed chitosan(Chi) gelatin(Gel) constructed...
Graves' disease (GD) is a common organ-specific autoimmune disease, and its pathogenesis still unclear. The aim of this study to investigate the role interleukin (IL)-21 in regulation Th17/Treg cells GD. We recruited 28 newly diagnosed GD patients, 27 patients remission (eGD), 24 normal controls (NC). Thyroid function autoantibodies were evaluated by electrochemical luminescence. Peripheral blood mononuclear (PBMCs) isolated cultured with or without recombinant human interleukin-21...
Abstract Bacterial infection and poor osteogenic capacity can result in the loosing or failure of titanium (Ti)‐based implants clinic. Therefore, it is urgent to design an effective approach enhance property restrict bacterial activity. In this study, a layered double hydroxide (LDH) composed Ga Sr ions on Ti substrates by hydrothermal method, then calcined 250°C denoted as LDH250. The scanning electron microscopy (SEM), X‐ray diffraction (XRD), photoelectron spectroscopy (XPS) were...
Abstract While the exact mechanism remains unclear, type 2 diabetes mellitus increases risk of sarcopenia which is characterized by decreased muscle mass, strength, and function. Whole-transcriptome RNA sequencing informatics were performed on diabetes-induced model db/db mice. To determine specific function lncRNA Gm20743 , detection Mito-Sox, reactive oxygen species, Ethynyl-2′-deoxyuridine, myosin heavy chain was in overexpressed knockdown- C2C12 cells. RNA-seq data revealed key...
Human fibroblast growth factor 19 (FGF19) has become a potential therapeutic target for metabolic-related diseases. However, the effects of FGF19 on obesity-induced bone loss have not been completely elucidated. The aim this study was to investigate protective in high-fat diet (HFD)-fed obese mice and palmitic acid (PA)-treated osteoblasts further explore its underlying mechanisms. In vivo, we found that alleviated decreased mineral density (BMD) induced by HFD. Micro-CT analysis femur...
Abstract RADA16 is a self‐assembling peptide material with good bioactivity. To improve the bioactivity of material, some specific functional motifs can be added to its sequence. Here, we report nanogel, RADA16‐RGD, that has better than and simultaneously carry control release two growth factors, VEGF BMP‐2, which have synergistic effects on bone formation. The materials were characterized by transmission electron microscopy scanning microscopy. mechanical properties peptides evaluated...
Nucleotide-binding oligomerization domain 1 (NOD1), a cytosolic pattern recognition receptor protein, plays crucial role in innate immune responses. However, the functional expression of NOD1 mesenchymal stem cells (MSCs) derived from endometriosis remains unclear. The aim this study was to explore functions ectopic endometrial lesions. Tissues and MSCs were isolated both normal endometrium endometriosis. Immunohistochemistry real time quantitative polymerase chain reaction (RT-qPCR) used...
Clinical treatment of bone defects caused by trauma, tumor resection and other diseases, especially that can lead to infection, remains a major challenge. Currently, autologous implantation is the gold standard for defects, but it limited secondary trauma insufficient material. Moreover, postoperative infection an important factor affecting healing.AcN-RADARADARADARADA-CONH2 (RADA) new type self-assembling peptide(SAP) composed Arg,Ala,Asp amino acids was designed prepared. The “RADA”...