A5101679159- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Cytokine Signaling Pathways and Interactions
- Hemoglobinopathies and Related Disorders
- Antibiotics Pharmacokinetics and Efficacy
- HIV Research and Treatment
- Adenosine and Purinergic Signaling
- Virus-based gene therapy research
- Antimicrobial Resistance in Staphylococcus
- interferon and immune responses
- Microbial Metabolism and Applications
- Reliability and Agreement in Measurement
- Acute Kidney Injury Research
- Viral Infections and Immunology Research
- Bacterial biofilms and quorum sensing
- Hepatitis B Virus Studies
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammatory mediators and NSAID effects
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
Huazhong University of Science and Technology
2025
Nanchang University
2010-2023
First Affiliated Hospital of Nanchang University
2010-2023
Novartis (China)
2017
China National Center for Food Safety Risk Assessment
2017
Hubei University
2007
Osteoarthritis (OA) is a chronic and degenerative disease marked by inflammation extracellular matrix (ECM) degeneration, contributing to synovial cartilage destruction. Accumulating evidence has demonstrated that Liver receptor homolog-1 (LRH-1), an orphan nuclear receptor, mediates inflammatory response. However, there lack of regarding the regulatory role LRH-1 in OA pathogenesis. In this study, we confirmed chondrocytes expressed LRH-1, observed its upregulation both IL-1β-treated...
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long latency in infected individuals. Periodically latently virus can reactivate becomes significant cause morbidity mortality immunocompromised In latent infection, viral genome is suppressed heterochromatic state gene transcription silenced. Upon reactivation, repressive chromatin remodeled to an active form, allowing lytic transcription, initiated by expression Immediate Early (IE) genes. During this...
ObjectivesThis study aimed to assess the current incidence and risk factors for polymyxin B-associated acute kidney injury (AKI) in Chinese hospitals a more effective clinical use B.MethodsThis multicenter, retrospective cohort included patients from 14 teaching who received B therapy. Univariate multivariate logistic regression models were used determine associated with incident AKI. Furthermore, model was identify independent AKI.ResultsA total of 251 analysis. The overall AKI 33.5%. A...
Objective: To observe the efficacy and factors influencing sequential or combined tenofovir alafenamide fumarate (TAF) after treatment with entecavir (ETV) in patients chronic hepatitis B (CHB) low-level viremia (LLV). Methods: 126 CHB cases treated ETV antiviral therapy Department of Infectious Diseases First Affiliated Hospital Nanchang University from January 2020-September 2022 were retrospectively collected. Patients divided into a complete virologic response (CVR) group (n = 84) (LLV)...
Abstract The presence of left ventricular hypertrophy has been confirmed to be an independent risk factor for stroke and death in patients with atrial fibrillation. This retrospective study aimed evaluate the potential factors A series consecutive diagnosed fibrillation between June 2018 December 2019 were included. patients’ clinical data analyzed. cut-off values, sensitivity specificity calculated using a receiver operating characteristic curve. Among 87 fibrillation, 39 48 without...
To analyze the genotype-phenotype correlation among carriers from Guangdong with co-inherited hemoglobin Hb Westmead (HbWS) and β-thalassemia.Twenty three patients (including 9 males 14 females, aged 1-53 year old) were diagnosed by hematological analysis genetic testing. Complete blood cell count electrophoresis performed on a XE4000i automatic hemocyte analyzer. Hb, HbF HbA2 tested high performance liquid chromatography (HPLC). Gap-PCR was adopted to detect common thalassemia deletions....
Objective To explore the role of IL-1β in inhalation injury repairment through its effects on expression prostaglandin E_2 cultured airway fibroblasts mouse. Methods The vivo from male Kunming species mouse were randomly divided into control group and treatment group. superna-rant cells collected at different time after treated with IL-1β. expressions PGE_2, COX-2 mPGES1 protein supernatant measured by ELISA Western Blot. Results ①PGE_2 levels fibroblast supematant 8 h(148.2±28.3) ng/L,16...