A5103163325- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- DNA Repair Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- Gastrointestinal disorders and treatments
- Advanced Glycation End Products research
- Medical Imaging and Pathology Studies
- Prostate Cancer Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- Thermal Regulation in Medicine
- Trigeminal Neuralgia and Treatments
- Respiratory Support and Mechanisms
- Histone Deacetylase Inhibitors Research
Peking Union Medical College Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Nanchang University
2014-2023
First Affiliated Hospital of Nanchang University
2014-2023
China-Japan Friendship Hospital
2023
Weatherford College
2020
Ethica (Canada)
2020
University of Hertfordshire
2020
Creative Research Enterprises (United States)
2020
Jiangxi Provincial People's Hospital
2020
Other SectionsABSTRACTINTRODUCTIONRESULTSDISCUSSIONMATERIALS AND METHODSACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGURESREFERENCES
Abstract Idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease, usually leads to an irreversible distortion of the structure. The functional roles bone marrow‐derived mesenchymal stem cells (BMSC)‐secreted extracellular vesicles (EVs) in fibroblasts have been implicated, yet their actions treatment IPF are not fully understood. This study investigated BMSC‐derived EVs expressing miR‐29b‐3p treatment. derived from BMSCs were successfully isolated could be internalized by...
Traumatic brain injury (TBI) is a leading cause of disability in adults, significantly affecting patients' quality life. Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have demonstrated therapeutic potential TBI treatment. However, their limited targeting ability, short half-life, and low bioavailability present significant challenges for clinical application. In this study, we engineered extracellular (EEVs) by transfecting hADSCs with...
Helicobacter pylori (H. pylori) infection is a well-recognized contributing factor to gastritis, but the underlying mechanisms remain be established. It interesting note that AQP5 was predicted highly expressed in intestinal metaplasia (IM) based on H. infection-related microarray data, and transcription ASCL1 bioinformatically associate with AQP5. Therefore, purpose of this study evaluate mechanistic significance gastritis. Gastritis mouse models were established by infection, followed...
Abstract Background Histone deacetylases (HDAC) contribute to oncogenic program, pointing their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of HDAC inhibitor ITF2357 in resistance mutant (mut)-KRAS non-small cell lung cancer (NSCLC) pemetrexed (Pem). Methods We first determined expression NSCLC tumorigenesis-related HDAC2 and Rad51 tissues cells. Next, we illustrated effect on Pem wild type-KARS line H1299, mut-KARS A549 Pem-resistant A549R vitro...
Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs, which have the ability to influence chemo-resistance lung adenocarcinoma (LAC). In this study, we explored mechanism by LINC00485 competitively binds microRNA-195 (miR-195) in regulation chemotherapy sensitivity LAC regulating checkpoint kinase 1 (CHEK1).Microarray analysis was used screen out related genes, and interaction between CHEK1 miR-195, as well that miR-195 LINC00485, further confirmed RNA-pull down RIP....
YY1 affects tumorigenesis and metastasis in multiple ways. However, the function of potential mechanisms through which it operates gastric cancer (GC) progression by regulating autophagy remains poorly understood. This study aimed to assess essential transcription factors (TFs) involved regulation GC. Western blot, RFP-GFP-LC3 double fluorescence transmission electron microscopy (TEM) assays were used probe activity GC cells. Methylated RNA immunoprecipitation (MeRIP) was utilized evaluate...
Prostatic cancer (PCa) is a leading cause of related death in males and often regarded as kind androgen-sensitive cancer. Artesunate (ART), semi-synthetic derivative the Chinese herb Artemisia annua, such an anti-cancer agent. However, effects mechanism ART on PCa cells remains unclear. The study aims to elaborate involvement androgen receptor (AR) anti-prostatic artesunate (ART). 22rvl were used vivo vitro, viability apoptosis conducted using...
The present study aimed to evaluate microRNA- 20b-5p (miR-20b-5p) expression in non-small cell lung cancer (NSCLC), and investigate the effects of miR-20b-5p on NSCLC proliferation migration. Reverse transcription-quantitative polymerase chain reaction was performed measure level tissues lines. Cell Counting Kit-8 wound healing assays were used A dual-luciferase reporter assay validate B-cell translocation gene 3 (BTG3) as a target miR-20b-5p. It identified that is elevated overexpression...
Background Chronic intermittent hypoxia (CIH) has been regarded as an important cause of atherosclerotic disease. In our study, we set out to investigate whether CIH regulated the high mobility group box 1/receptor for advanced glycation endproducts/NOD‐like receptor family pyrin domain‐containing 3 (HMGB1/RAGE/NLRP3) axis affect progression atherosclerosis. Methods and Results Initially, peripheral blood samples were collected from patients with single obstructive sleep apnea,...
OBJECTIVE Although CT-guided selective percutaneous radiofrequency thermocoagulation (PRFT) via the foramen rotundum (FR) has been used in clinic as a novel successful treatment for isolated, second division (maxillary nerve [V2]), idiopathic trigeminal neuralgia (ITN), there is only very limited related literature published to date. This report aims provide more detail physicians about this technique. METHODS Between March 2013 and April 2014, 20 patients with isolated V2 ITN refractory or...
Abstract Brain metastasis is a common site of distant non-small-cell lung cancer (NSCLC) that greatly reduces the prognosis patients. In this study, we explored correlation between different clinical factors and secondary brain metastases in NSCLC an attempt to identify patient populations at high risk central nervous system. We collected data for 350 patients from medical record system First Affiliated Hospital Nanchang University June 2015 2019, these had pathologically verified diagnoses....
The prevalence of depression in patients with chronic obstructive pulmonary disease (COPD) ranges from 10% to 42%, but the diagnosis COPD is often unrecognized and untreated. Unrecognized has major implications for compliance medical treatment, prolonged lengths stay, increased frequency hospital admissions, consultations primary care physicians. Many studies have attempted identify risk factors progression, prognosis response therapy depression. However, few examined COPD, some results...
Abstract Idiopathic pulmonary fibrosis (IPF) is a condition that results in the progressive deterioration of lung function with poor prognosis. The current study aimed at exploring how microRNA‐448 (miR‐448) targeting ABCC3 affects fibroblast proliferation, apoptosis, and collagen synthesis mice IPF via Jun N‐terminal kinase (JNK) signaling pathway. Bioinformatics dual‐luciferase polymerase chain reaction were used to predict relationship miR‐448 ABCC3. expression was detected tissues. Using...
Intestinal metaplasia (IM) and dysplasia are precancerous lesions of gastric cancer (GC); however, the prevalence IM in patients exhibiting single ulcer (GU) concomitant duodenal (CGDU) varies. In present study consecutive who had undergone esophagogastroduodenal endoscopy were retrospectively screened, those presenting with GU or CGDU further evaluated for dysplasia. Patients diagnosed GC lymphoma a history anti-Helicobacter pylori, non-steroidal anti-inflammatory medicine (NSAIM),...
Abstract It remains challenging for endoscopists to manage pancreaticobiliary diseases in patients with ectopic papilla of Vater by endoscopic retrograde cholangiopancreatography (ERCP). The present study sought evaluate the efficacy and safety ERCP this issue. Consecutive who underwent initial due were retrospectively analyzed. One hundred seven included. success rate cannulation was 83.2%. Endoscopic sphincterotomy, papillary balloon dilation, mechanical lithotripsy performed 12 (11.2%),...
In this study, extractive electrospray ionization and mass spectrometry (EESI-MS) was used to evaluate whether volatile organic compounds (VOCs) in exhaled gases can serve as specific diagnostic markers of lung cancer. The patients with cancer were diagnosed by chest CT or X-ray exam confirmed histopathology cytology. Patients pulmonary infections identified imaging, pathological diagnosis, improvement symptoms after antiinflammatory treatment. control group had no abnormalities imaging....
Non-small cell lung cancer (NSCLC) is the most common type of cancer. The high expression osteopontin (OPN) an important factor that aggravates drug resistance and causes a poor prognosis in this disease. Therefore, understanding molecular mechanism OPN critical for treatment NSCLC.We used bioinformatics analysis to verify normal tissues tissues. Then we overexpressed knocked down lines detect proliferation, migration, invasion, effects on signaling pathways. Finally, malignant progression...
Abstract Addressing pancreaticobiliary disorders concomitant with gastroesophageal varices remains challenging. The goal of this study was to evaluate and compare the efficacy safety endoscopic retrograde cholangiopancreatography (ERCP) in cirrhotic noncirrhotic patients varices. We retrospectively analyzed data consecutive who underwent ERCP. Two hundred seventy ERCP procedures were performed on 208 patients. overall technical success rate 98.5%, no difference found between (98.7% vs 97.7%,...
The aim of this study was to estimate the prevalence and risk factors intestinal metaplasia (IM) in concomitant gastric duodenal ulcer (CGDU) disease by retrospectively reviewing consecutive patients who had undergone esophagogastroduodenal endoscopy. Patients received endoscopic diagnosis CGDU were selected for analysis recorded demographic, endoscopic, clinical outcome data, including data on development IM, extracted. Associations various parameters with IM estimated logistic regression...
Abstract The presence of left ventricular hypertrophy has been confirmed to be an independent risk factor for stroke and death in patients with atrial fibrillation. This retrospective study aimed evaluate the potential factors A series consecutive diagnosed fibrillation between June 2018 December 2019 were included. patients’ clinical data analyzed. cut-off values, sensitivity specificity calculated using a receiver operating characteristic curve. Among 87 fibrillation, 39 48 without...