A5101732742- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Acute Ischemic Stroke Management
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinopathy of Prematurity Studies
- Spondyloarthritis Studies and Treatments
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Spinal Cord Injury Research
- Cerebral Venous Sinus Thrombosis
- RNA and protein synthesis mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
Peking Union Medical College Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Chang Gung University
2014-2025
Huizhou Central People's Hospital
2024-2025
Kaohsiung Chang Gung Memorial Hospital
2014-2025
University of Chinese Academy of Sciences
2023-2025
Zhejiang Chinese Medical University
2024-2025
Anhui Medical University
2022-2025
Chinese Academy of Sciences
2023-2025
Second Hospital of Anhui Medical University
2022-2025
Atherosclerosis is a leading cause of death worldwide. Recent studies have emphasized the significance gut microbiota and lipid metabolism in development atherosclerosis. Herein, effects molecular mechanisms involving ferulic acid (FA) was examined atherosclerosis using ApoE-knockout (ApoE -∕- , c57BL/6 background) mouse model. Eighteen male ApoE −/− mice were fed high-fat diet (HFD) for 12 weeks then randomly divided into three groups: model group, FA (40 mg/kg/day) group simvastatin (5...
Dingxin Recipe (DXR) is a traditional Chinese medicine formula that has been reported to be effective and safe treatment for cardiovascular diseases, such as arrhythmias, coronary heart disease. IV (DXR IV) was further improved from the DXR according use. However, mechanism of in atherosclerosis unclear. This study aimed illustrate whether improve through modulating lipid metabolism gut microbiota mice. 40 male ApoE-/- mice were fed on HFD 12 weeks then treated with (1.8, 0.9, or 0.45...
Injectable hydrogels can perfectly fill defective areas and thereby show promise as therapeutic implants or cell/drug delivery vehicles in traumatic brain injury (TBI) other tissue repair. In this study, an injectable gelatin hydrogel situ dual-enzymatically cross-linked by glucose oxidase (GOX) horseradish peroxidase (HRP) was synthesized optimized, the effect of encapsulated with bone mesenchymal stem cells (BMSC) for TBI rats investigated. By changing GOX content, we found that 0.1 U mL-1...
Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus and is characterized by myocardial hypertrophy fibrosis. Pyrroloquinoline quinone (PQQ), natural nutrient, exerts strong protection against various diseases. Pyroptosis, type inflammation-related programmed cell death, vital to the development DCM. However, protective effects PQQ DCM associated mechanisms are not clear. This study aimed investigate whether protected determine underlying molecular mechanism.Diabetes was...
Diabetic nephropathy (DN), which is characterized by renal fibrosis, a major complication of diabetes, disease that afflicted more than 460 million people worldwide in 2019. Pyroptosis an essential signaling pathway DN-related injuries, such as fibrosis. Pyrroloquinoline quinone (PQQ) naturally occurring bioactive compound protects human kidney 2 (HK-2) cells from oxidative stress-induced damage caused high glucose concentrations. However, the nature and underlying mechanism effect PQQ on...
In situ forming hydrogel shows enormous potential as a therapeutic implant or carrier in tissue repair and regeneration. It can perfectly seal fill the defective tissue, consequently functioning cell/drug delivery vehicle. this contribution, new gelatin with dual-enzymatic cross-linking of horseradish peroxidase (HRP) galactose oxidase (GalOx) was developed, effect encapsulated bone mesenchymal stem cells (BMSC) dermal wound healing investigated. This possesses quick gelation process within...
Excessively deposited fibrotic scar after spinal cord injury (SCI) inhibits axon regeneration. It has been reported that platelet-derived growth factor receptor beta (PDGFRβ), as a marker of scar-forming fibroblasts, can only be activated by (PDGF) B or PDGFD. However, whether the activation PDGFRβ pathway mediate formation SCI remains unclear.A compression mouse model was used. In situ injection exogenous PDGFB PDGFD in used to specifically activate uninjured cord, while intrathecal SU16f...
Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as main barrier to axonal regeneration resulting permanent functional recovery failure. Pericytes were shown be source fibroblasts that form fibrotic scar. However, mechanism pericyte-fibroblast transition after SCI remains elusive.Fibrotic scarring microvessels assessed using immunofluorescence staining establishing a crush model. To study...
Glaucoma is a chronic neurodegenerative disease that poses significant threat of irreversible blindness worldwide. Current treatments for glaucoma focus on reducing intraocular pressure (IOP), which the only modifiable risk factor. Traditional anti-glaucomatous agents, including carbonic anhydrase inhibitors, beta-blockers, alpha-2 agonists, and prostaglandin analogs, work by either improving uveoscleral outflow or aqueous humor production. Rho kinase (ROCK) inhibitors represent novel class...
Intracerebral hemorrhage (ICH) is a severe stroke subtype with limited therapeutic options.Programmed cell death (PCD) crucial for immunological balance, and includes necroptosis, pyroptosis, apoptosis, ferroptosis, necrosis.However, the distinctions between these programmed modalities after ICH remain to be further investigated.We used single-cell transcriptome (single-cell RNA sequencing) spatial (spatial techniques investigate PCD-related gene expression trends in rat brain following...
Abstract Background Myelin-laden foamy macrophages accumulate extensively in the lesion epicenter, exhibiting characteristics of autophagolysosomal dysfunction, which leads to prolonged inflammatory responses after spinal cord injury (SCI). Trehalose, known for its neuroprotective properties as an autophagy inducer, has yet be fully explored potential mitigate macrophage formation and exert therapeutic effects context SCI. Results We observed that trehalose significantly enhances...
Background: Ankle proprioception deficit is a major factor causing balance dysfunction in subacute stroke survivors. However, there still no commonly-agreed ankle evaluation method for these patients. Whether tested by the active movement extent discrimination apparatus (AMEDA) when participants are standing (AMEDA-standing) or sitting (AMEDA-sitting). Objectives: This study aimed to investigate variations measures between AMEDA-standing and AMEDA-sitting survivors assess test-retest...
Traumatic brain injury (TBI) is a leading cause of disability in adults, significantly affecting patients' quality life. Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have demonstrated therapeutic potential TBI treatment. However, their limited targeting ability, short half-life, and low bioavailability present significant challenges for clinical application. In this study, we engineered extracellular (EEVs) by transfecting hADSCs with...
Background: Visual training based on perceptual learning and dichoptic stimulation has been developed for amblyopic treatment. However, reports virtual reality-assisted (VR) amblyopia are limited. The aim of this study was to evaluate the effects VR compare visual outcomes different treatments in children with bilateral refractive amblyopia. Methods: Children aged 4–8 years a best-corrected acuity (BCVA) less than 20/25 were included. All patients had worn glasses at least 2 months before...