A5101790329- Ionosphere and magnetosphere dynamics
- Geomagnetism and Paleomagnetism Studies
- Solar and Space Plasma Dynamics
- Astro and Planetary Science
- Earthquake Detection and Analysis
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Esophageal Cancer Research and Treatment
- Nanoplatforms for cancer theranostics
- Advanced Computational Techniques and Applications
- Medical Image Segmentation Techniques
- GaN-based semiconductor devices and materials
- Planetary Science and Exploration
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- Metal and Thin Film Mechanics
- Diamond and Carbon-based Materials Research
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- Nuclear Physics and Applications
- Advanced Decision-Making Techniques
- Magnetic confinement fusion research
- ZnO doping and properties
- Magnetic Field Sensors Techniques
- Educational Technology and Assessment
Nanjing Medical University
2025
Nanjing University
2025
Zhengzhou University
2018-2024
Nanjing University of Information Science and Technology
2023-2024
Chinese Academy of Civil Aviation Science and Technology
2024
Chinese Academy of Sciences
1993-2024
Shanghai Institute of Ceramics
2021-2024
National Space Science Center
1998-2024
Anhui Jianzhu University
2024
Yangtze Normal University
2008-2022
Mutations in mitochondrial DNA (mtDNA) play critical roles many human diseases. In vivo visualization of cells bearing mtDNA mutations is important for resolving the complexity these diseases, which remains challenging. Here we develop an integrated nano Cas12a sensor (InCasor) and show its utility efficient imaging live tumor-bearing mouse models. We co-deliver Cas12a/crRNA, fluorophore-quencher reporters Mg2+ into mitochondria. This process enables activation Cas12a's trans-cleavage by...
Injectable hydrogels can perfectly fill defective areas and thereby show promise as therapeutic implants or cell/drug delivery vehicles in traumatic brain injury (TBI) other tissue repair. In this study, an injectable gelatin hydrogel situ dual-enzymatically cross-linked by glucose oxidase (GOX) horseradish peroxidase (HRP) was synthesized optimized, the effect of encapsulated with bone mesenchymal stem cells (BMSC) for TBI rats investigated. By changing GOX content, we found that 0.1 U mL-1...
The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts Interest none was reported.
Summary A region growing algorithm for segmentation of human intestinal gland images is presented. The initial seeding regions are identified based on the large vacant (lumen) inside glands by fitting with a very moving window. then expanded repetitive application morphological dilate operation much smaller round window structure set. False (nongland initially misclassified as regions) removed either their excessive ages active growth or inadequate thickness dams formed strings goblet cell...
Inhibition of residual malignant tumors in patients with colon cancer after operation is one the difficulties rehabilitation treatment. At present, using biocompatible materials to remove copper ion which growth dependence lesion site considered be frontier means solve this problem. In work, we developed a sodium alginate (SA)/polyethyleneimine (PEI) hydrogel sphere via cross-linking method (SA/SP/SA; SP = SA/PEI) as an oral biomaterial for adsorbing and removing ions from lesions. The...
Magnesium (Mg)-based alloys have been regarded as promising implants for future clinic orthopedics, however, how to endow them with good anti-corrosion and biofunctions still remains a great challenge, especially complicated bone diseases. Herein, three transition metals (M = Mn, Fe, Co)-containing layered double hydroxides (LDH) (LDH-Mn, LDH-Fe, LDH-Co) similar M content are prepared on Mg alloy via novel two-step method, then systematic characterizations comparisons conducted in detail....
Following our earlier work on tomographic reconstruction of the magnetosheath soft X-ray emissions with superposed epoch analysis many images recorded from a single spacecraft we now explore instantaneous and magnetopause using few simultaneously spacecraft. This is motivated by prospect possibly having two or three imagers in space coming years, that phenomena which occur at boundary, such as reconnection events pressure pulse responses, do not lend themselves well to analysis. If...
The rapid corrosion rate and limited biological functionality still pose challenges for magnesium (Mg)-based implants in the treatment of complicated bone-related diseases clinic. Herein, a multifunctional biodegradable curcumin (herbal medicine)-ferrum (Cur-Fe) nanoflower was self-assembled on plasma electrolytic oxidation (PEO)-treated Mg alloy via facile immersion process to realize differential function anti-bacteria/tumor bone regeneration. results indicated that Cur-Fe coating can...
A high-performance planar structure metal–semiconductor–metal-type solar-blind photodetector (SBPD) was fabricated on the basis of (010)-plane β-Ga2O3 thermally oxidized from nonpolar (110)-plane GaN. full width at half maximum 0.486° achieved for X-ray rocking curve associated with (020)-plane β-Ga2O3, which is better than most reported results heteroepitaxially grown (−201)-plane β-Ga2O3. As a result relatively high crystalline quality, dark current as low 6.30 × 10–12 5 V, while...
Abstract We present an initial assessment of using tomography on single‐spacecraft images to reconstruct 3D X‐ray emissions from the Earth's magnetosheath. structures in magnetosphere have been studied superposed epoch techniques with single‐point observations. They yielded great insights, but some studies are observation starved, particularly for infrequent solar wind conditions. Global imaging data provided more insight about these structures, 2D projections structures. explore use...
Abstract The repair of bone defects caused by osteosarcoma resection remains a clinical challenge because the tumor recurrence and bacterial infection. Combining therapy with regeneration properties in implants is promising strategy for treatment osteosarcoma. Here, layer MgO/FeO x nanosheet constructed on Ti implant to prevent infection, while simultaneously accelerating formation. This double metal oxide demonstrates good peroxidase activity catalyze H 2 O , which rich microenvironment,...
It is generally accepted that stent implantation the mainstream therapy in clinics for esophageal cancer later period. However, restenosis caused by tumor cells, epithelial and fibroblasts seriously interferes with medical application limits its long-term services. To address this conundrum, a series of drug-eluting stents were invented verified to be feasible early stage after implantation, but limited drug loading good cell compatibility materials may lead more serious further endanger...
Site-specific imaging of target genes using CRISPR probes is essential for understanding the molecular mechanisms gene function and engineering tools to modulate its downstream pathways. Herein, we develop CRISPR/Cas9-mediated signal amplification by exchange reaction (CasSABER) programmable in situ low nonrepetitive regions cell nucleus. The presynthesized primer-exchange (PER) probe able hybridize multiple fluorophore-bearing imager strands specifically light up dCas9/sgRNA target-bound...
Nonpolar (112¯0) a-plane GaN films were grown on semipolar (11¯02) r-plane sapphire substrates using various buffer layers within a low-pressure metal organic chemical vapor deposition system. The structural properties of nonpolar intensively investigated by X-ray diffraction and Raman spectra measurements. A set adopted from layer to composite containing multiple AlN gradually varied-Al-content AlGaN layer, the full width at half maximum rocking curves measured along [0001] [101¯0]...
Clustering analysis has been widely used in pattern recognition, image processing, machine learning, and so on. It is a great challenge for most existing clustering algorithms to discover clusters with complex manifolds or density variation. Most of the needs manually set neighborhood parameter K search neighbor each object. In this paper, we use natural adaptively get value Then, define two novel concepts, core point distance between solve manifold problem. On basis above-proposed concept,...
Metal stent implantation is usually applied to alleviate nonoperative palliative esophageal obstruction for cancer in the later period. However, in-stent restenosis after limits stents' performance due lack of effective suppression pathological cells from microenvironment. In previous work, we modified material 317L stainless steel (317LSS) surface with a poly-dopamine/poly-ethylenimine/5-fluorouracil layer (PDA/PEI/5-Fu), which had strong anti-tumor and anti-restenosis functions....