A5113578289- CRISPR and Genetic Engineering
- Bladder and Urothelial Cancer Treatments
- Pharmacology and Obesity Treatment
- Epigenetics and DNA Methylation
- Entomopathogenic Microorganisms in Pest Control
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Anesthesia and Neurotoxicity Research
- Renal Diseases and Glomerulopathies
- Healthcare and Venom Research
- Insect Resistance and Genetics
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Natural Antidiabetic Agents Studies
- Occupational and environmental lung diseases
- NF-κB Signaling Pathways
- Coenzyme Q10 studies and effects
- Advanced Nanomaterials in Catalysis
- Computational Drug Discovery Methods
- Quinazolinone synthesis and applications
Hangzhou Medical College
2022-2025
Anhui Medical University
2020-2025
Chuzhou University
2025
University of Michigan–Ann Arbor
2015-2024
Zhejiang University
2021-2023
University of Maryland, Baltimore
2019-2023
Central South University
2023
Huazhong University of Science and Technology
2023
Qingdao University
2023
Children's Hospital of Fudan University
2023
This study sought to explore the characteristics of de qi using electroacupuncture at acupoints with different properties in meridian category, histological type, and nerve innervations.Electroacupuncture was performed on 21 healthy volunteers paired ST36-GB34, CV4-CV12, ST36-ST28, PC6-PC7, ST36-CV4. Upon acupuncture qi, intensities prevalence individual sensations, sensation transmission, amplitude electrical current were recorded. Chi-square, Fischer's exact test, Wilcoxon two-sample t...
Abstract Bladder cancer is a common and deadly malignancy but its treatment has advanced little due to poor understanding of the factors pathways that promote disease. ATDC/TRIM29 highly expressed gene in several lethal tumor types, including bladder tumors, role as pathogenic driver not been established. Here we show overexpression ATDC vivo sufficient drive both noninvasive invasive carcinoma development transgenic mice. ATDC-driven tumors were indistinguishable from human cancers, which...
Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus and is characterized by myocardial hypertrophy fibrosis. Pyrroloquinoline quinone (PQQ), natural nutrient, exerts strong protection against various diseases. Pyroptosis, type inflammation-related programmed cell death, vital to the development DCM. However, protective effects PQQ DCM associated mechanisms are not clear. This study aimed investigate whether protected determine underlying molecular mechanism.Diabetes was...
Anandamide (ANA), an endogenous cannabinoid, can be generated by activated macrophages during endotoxin shock and is thought to a paracrine contributor hypotension. We discovered that ANA in saline/ethanol solution serum was efficiently adsorbed polymyxin B (PMB)‐immobilized beads column eluted with ethanol. confirmed the direct binding of PMB using surface plasmon resonance. The adsorption may abolish diverse effects such as hypotension, immunosuppression, cytotoxicity, suggest new...
Toll-like receptors 2 and 4 (TLR2 TLR4) have been found to transduce signals of peptidoglycan (PGN) lipopolysaccharide (LPS), respectively, for NF-kappa B activation. However, little is known about the expression regulation TLR2 gene in monocytes/macrophages response two typical bacterial products. We show present study that both PGN a high concentration LPS increase macrophage-like cells, 1 alpha,25-dihydroxyvitamin D(3)-differentiated human HL60 mouse RAW264.7 monocytes dose-...
Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with various clinical features influencing its prognosis. The aim of this study to evaluate the impact platelet count at diagnosis and recovery after induction chemotherapy on survival outcomes elderly AML patients. A total 109 patients who were treated in our center between 2017 2023 evaluated. According median counts time new diagnosis, cases divided into low group (≤40×109/L, n=54) high (>40×109/L, n=55)....
The Chlamydomonas reinhardtii (red) is a strain rich in protoporphyrin IX, which could be used as algal-derived novel sustainable nutritional sources. However, the safety research on C. remains insufficient and further investigation needed. In order to assess of expand its use food applications, series toxicological evaluations were carried out observe acute toxicity, subchronic toxicity genotoxicity (red). was administered an oral test, mammalian micronucleus mouse chromosomal aberration...
Rationale: Rheumatoid arthritis (RA) is a prototype of inflammatory in which synovial fibroblasts (SFs) play key roles cartilage and bone destruction through tumor-like proliferation, migration, invasion inflammation. This study aimed to research forkhead box protein C1 (FoxC1) microRNA (miR)-141-3p, modulate pathological changes the membrane, find possible strategies for treating RA. Methods: FoxC1, β-catenin miR-141-3p gene expression tissues SFs was quantified by real-time PCR; FoxC1...
Abstract: The metastasis of cancer cells is a vital aspect disease progression and therapy. Although few nanoparticles (NPs) aimed at controlling in therapy have been reported, the NPs are normally combined with drugs, yet direct therapeutic effects not reported. To study influence on metastasis, potential suppression capacity [email protected] 2 -PEG to tumor cell migration, kind typical photothermal NPs, was systemically evaluated this study. Using NP stimulation transwell migration...
<title>Abstract</title> Background Dyslipidemia is a chronic, metabolic disease characterized by elevated level of serum total cholesterol (TC) or low-density lipoprotein (LDL-C), and acts as key contributor to the development cardiovascular diseases (CVDs). Our previous work has shown that whole grain oat supplementation exerted cholesterol-lowering properties modulating gut microbiota in individuals with hyperlipidemia. However, it not clear whether effect depends on its metabolites. In...
Abstract Current cancer therapies typically give rise to dose-limiting normal tissue toxicity. We have developed KLIPP, a precision approach that specifically kills cells using CRISPR/Cas9 technology. The consists of guide RNAs target cancer-specific structural variant junctions nucleate two parts dCas9-conjugated endonuclease, Fok1, leading its activation. show KLIPP causes induction DNA double strand breaks (DSBs) at the targeted and cell death. When were grown orthotopically in mice,...
The announcement of world’s first genome-edited babies using CRISPR/Cas 9 has provoked shock around the world. popular technique allowed great scientific and medical advances, but it also raises ethical issues. Therefore, we attempted to design a new pattern class help students understand both technical principles this cutting-edge genome-editing explore key controversies in its use, so as cultivate students’ concept ethics. feedback showed that organization resulting discussion were very...
Macrocentrus cingulum is a principal endoparasite of Ostrinia furnacalis larvae. M. larvae repress host immune responses for survival and ingest nutrients development until emerging. However, most investigations focused on the mechanisms how wasps immunity, triggered nutrient status altered by in are neglected. In this study, we found that parasitized O. activated fast recognition produced some effectors such as lysozyme antimicrobial peptides, along with more consumption trehalose, glucose,...
An understanding of how to safely apply intraoperative blood salvage (IBS) in cancer surgery has not yet been obtained. Here, we investigated the optimal dose 137Cs gamma-ray irradiation for killing human hepatocarcinoma (HepG2), gastrocarcinoma (SGC7901), and colonic carcinoma (SW620) tumor cells while preserving co-cultured erythrocytes obtained from 14 healthy adult volunteers. HepG2, SGC7901, or SW620 were mixed into aliquots erythrocytes. After treated with (30, 50, 100 Gy), separated...
Abstract Current cancer therapeutic treatments are typically associated with significant collateral damage to normal tissues and the emergence of treatment resistance. Thus, there is an unmet need develop therapies that uniquely specific unhindered by We have developed RNA therapy approach based on CRISPR technology, known as “KLIPP”, targets cancer-specific structural variant junctions (SVJs), a so far untapped “Achilles heel”, highly abundant across types. KLIPP uses “split enzyme” system...
Abstract This study aimed to assess the bioequivalence of 2 avapritinib tablets formulations. A randomized, open‐label, single‐center trial was conducted on fasting, healthy Chinese participants. The utilized a partial replicated design with 3 sequences and periods. Participants were assigned 1 sequences, each sequence receiving reference formulation twice test once. Plasma samples collected analyzed determine pharmacokinetic parameters. formulations assessed using reference‐scaled average...
Abstract Background: Treatment of muscle-invasive bladder cancer remains challenging and, BCG, one the few treatments that prevents progression high-risk non-muscle invasive tumors to metastatic disease, is difficult obtain. Thus, development new treatment approaches block muscle disease essential. We find TRIM29 (tripartite motif containing 29, also known as ATDC), drives through modulation focal adhesions FAK and c-Src (Src). Despite this, literature has reported conflicting effects Src...
Introduction: Hypoxia-inducible factor 1α (HIF-1α) is a transcription that acts as master regulator for the expression of genes promote tumor growth, vascularization, and metastasis, highly expressed in cancer tissues. HIF-1α activates by binding to hypoxia response elements (HRE) promoter region its target genes. inhibition has shown success therapeutic strategy mouse models metastatic cancer. Therefore, represents prime molecular therapy. However, no specific HIF inhibitor been approved...