A5101024258- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Sarcoidosis and Beryllium Toxicity Research
- Complement system in diseases
- Nanoparticle-Based Drug Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hepatitis B Virus Studies
- Retinal Development and Disorders
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Graphene and Nanomaterials Applications
- Chronic Kidney Disease and Diabetes
- Hepatitis C virus research
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Mesenchymal stem cell research
- Optical Coherence Tomography Applications
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- Heart Failure Treatment and Management
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2017-2024
Dalian University
2023
Dalian University of Technology
2023
Hangzhou Center for Disease Control and Prevention
2019-2022
Zhejiang Center for Disease Control and Prevention
2019-2022
This study aims to identify biomarkers for reliably predicting diabetic kidney disease (DKD), systematically characterize serum metabolites and gut microbiota in DKD patients, investigate the correlation between differential microbiota. From September 2021 January 2023, 90 subjects were recruited: 30 with DKD, type 2 diabetes mellitus (T2DM), normal controls (NCs). Serum metabolites, including 180 different analyzed using untargeted metabolomics UPLC-MS/MS, assessed via 16S rRNA sequencing....
Ferroptosis is a newly identified form of cell death that regulated by many metabolic pathways, including iron, lipid and amino acids. Recent two studies reveal the mitochondria energy stress could also mediate ferroptosis. Gao et al. report play an essential role in ferroptosis induced cysteine deprivation. In addition, Lee show depressed partly through activation AMP-activated protein kinase. These findings provide potential therapeutic strategies for treating ferroptosis-related diseases,...
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The characteristics and the pathogenesis of concomitant antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) immunoglobulin G4-related disease (IgG4-RD) have not been elucidated.We included 92 AAV patients with renal biopsy results. Among them, 10 met both IgG4-RD criteria (concomitant group). IgG subclasses myeloperoxidase (MPO)-ANCA in serum tissue were measured complement activation components detected serum.Patients group had elevated IgG4 levels positive MPO-ANCA....
Objective To evaluate the performance of European League Against Rheumatism/American College Rheumatology (EULAR/ACR) SLE classification criteria in a cohort patients with biopsy-confirmed lupus nephritis (LN) and their renal prognosis. Methods Patients newly diagnosed attending followed up for >12 months were included. A retrospective review all biopsy fulfilling consensus expert opinion during 2014 2018. Clinical, serological pathological data collected each patient was assigned...
Increased serum mannose-binding lectin (MBL) level has been proven to correlate with the development of diabetic nephropathy (DN). Here, we aim find role and mechanism MBL involved in progression DN. Patients DN were recruited divided into two groups according different rs1800450 genotypes MBL2 gene, inflammatory profiles monocytes/macrophages compared between groups. was given treat macrophages, HK2, HMC, a co-culture transwell system then employed. Renal inflammation fibrosis parameters...
We aimed to investigate whether mannose-binding lectin (MBL) activation contributed the progression of diabetic nephropathy (DN), and its role in predicting renal prognosis DN.Seventy-seven patients who received biopsy First Affiliated Hospital, College Medicine, Zhejiang University between August 2013 September 2016 were enrolled study. These followed up until endpoint end-stage disease (ESRD) or last follow-up time 31, 2018. They divided into ESRD group (33 patients) non-ESRD (44...
High-dose methylprednisolone pulses were one of the main treatments for anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitides (AAV) but had obvious side effects. We aimed to know impact on renal survival and identify prognostic factors this treatment in Chinese AAV patients with severe involvement. One hundred eleven an estimated glomerular filtration rate (eGFR) 10ml/min/1.73 m2 or less at admission included. The MP group (n = 57) received intravenous 500 mg/d 3 days,...
Microscopic polyangiitis (MPA) is an autoimmune disease characterized by frequent kidney involvement. Imbalance of intestinal flora has been found implicated in multiple immune-mediated disorders. However, the profiling and role gut microbiome MPA remains unclear.We performed 16S rRNA amplicon sequencing on fecal samples from 71 patients with involvement (35 at incipient active stage, 36 remissive stage) 34 healthy controls (HCs). Microbial diversity abundance were compared among three...
The renal injury caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are characterized few or no immune deposits in glomerulus. A growing number of AAV patients with glomerular immunoglobulin (Ig)A have been reported. We retrospectively investigated all IgA diagnosed our center. Serum galactose-deficient IgA1 (Gd-IgA1) level and Gd-IgA1 staining were measured. Moreover, we detected complement pathway components their sera. total 168 enrolled, including 26...
Background Kidney involvement is common in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). It tends to be aggressive, and some patients, the kidney may reach criteria of acute injury (AKI). Here, we aim describe clinical characteristics these patients find risk factors for poor outcomes. Methods Patients diagnosed with AAV our hospital from February 2003 2017 were included. Those who reached KDIGO AKI reclassified according stage. The features analyzed. Also,...
Abstract Cellular senescence is a widespread cellular programme that characterized by permanent cell cycle arrest. Senescent cells adopt changed secretory phenotype can alter function. For years, has been thought to be protective factor against cancer; however, it now recognized dual effect on individuals. Co‐ordinated activation of provides advantages during embryogenesis, wound healing, tissue repair and inhibition tumorigenesis. On the other hand, aberrant generation accumulation abnormal...
Abstract Optical coherence tomography (OCT) is a non-invasive imaging technique that generates cross-sectional images of biological tissues at millimeter-level penetration depth with micron-level resolution. In this study, we developed custom spectral-domain OCT (SD-OCT) system equipped flash stimulus module for dual-modality mouse retinal structure and function. The axial resolution the reached ~2.7/2 μm in air/tissue following optimization calibration. We deployed to conduct vivo...
<title>Abstract</title> <bold>Objective: </bold>This study aims to identify biomarkers for reliably predicting diabetic kidney disease (DKD), systematically characterize serum metabolites and gut microbiota in DKD patients, investigate the correlation between differential microbiota. <bold>Methods: </bold>From September 2021 January 2023, 90 subjects were recruited: 30 with DKD, type 2 diabetes mellitus (T2DM), normal controls (NCs). Serum metabolites, including 180 different analyzed using...
Glaucoma is a group of eye diseases characterized by the thinning retinal nerve fiber layer (RNFL), which primarily caused progressive death ganglion cells (RGCs). Precise monitoring these changes at cellular resolution in living eyes significant for glaucoma research. In this study, we aimed to assess effectiveness temporal speckle averaging optical coherence tomography (TSA-OCT) and dynamic OCT (dOCT) examining static potential properties RGCs RNFL mouse eyes. We evaluated parameters such...
Renal tubular impairment is prevalent in diabetic nephropathy (DN) and the histological severity predicted renal outcome. Biomarkers of injury also increased urine DN patients. The retrospective study aimed to assess prognostic value clinically widely applied urinary markers, retinol-binding protein (RBP), β2-microglobulin (β2-MG) N-acetyl-β-D-glucosaminidase (NAG) DN. A total 305 patients with biopsy-proven were enrolled. baseline components including albumin, IgG, RBP, β2-MG NAG retrieved...
Objective To analyze the pathological characteristics and prognostic factors of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods A retrospective analysis AAV patients with renal biopsy results admitted to Kidney Disease Center First Affiliated Hospital from January 2004 February 2017 was performed. The were divided into 4 types according Berden classification, their clinical, prognosis compared. survival curves each type plotted by Kaplan-Meier method,...