A5101555114- Gallbladder and Bile Duct Disorders
- Sperm and Testicular Function
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Neonatal Respiratory Health Research
- T-cell and Retrovirus Studies
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Sepsis Diagnosis and Treatment
- Bioactive natural compounds
- Nanocluster Synthesis and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Mental Health Research Topics
- Chronic Myeloid Leukemia Treatments
- RNA Research and Splicing
- melanin and skin pigmentation
Anhui Medical University
2017-2025
First Affiliated Hospital of Anhui Medical University
2023-2025
Nanchang University
2023-2024
First Affiliated Hospital of Nanchang University
2023-2024
ShenZhen People’s Hospital
2020
Fourth Affiliated Hospital of Anhui Medical University
2019
Shanghai First People's Hospital
2016-2017
The University of Texas Medical Branch at Galveston
2013-2014
Shriners Hospitals for Children - Galveston
2012
McGill University
2005
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible lung disease. Studies have shown that epithelial-mesenchymal transition (EMT) plays an important role in the development of IPF. The NLRP3 inflammasome reported to be activated play many respiratory diseases. However, whether alveolar epithelial cells as well regulatory EMT not been reported. In this study, we transfected siRNA into A549 RLE-6TN treated them with bleomycin (BLM) for 24h. Then, detected expression...
Abstract Paraquat ( PQ ) poisoning‐induced pulmonary fibrosis is one of the primary causes death in patients with poisoning. Hypoxia‐inducible factor‐1α HIF ‐1α) and epithelial‐mesenchymal transition EMT are involved progression fibrosis. Snail β‐catenin two other factors promoting . However, relationship among ‐1α, not clear. Our research aimed to determine whether regulation ‐1α occurs via pathways Sixty‐six Sprague–Dawley rats were randomly evenly divided into a control group group. The...
Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green safe coating technology that functionalizes probiotics with nanozymes while preserving activity both components remains challenge. To address this, chitosan‐modified epigallocatechin gallate (EGCG‐CS, EC)is synthesized, leveraging intrinsic adhesive...
Breast cancer is the most common malignant in women worldwide, especially developing countries. Herceptin a monoclonal antibody with an antitumor effect HER2-positive breast cancer. However, large molecular weight of limited its employment. In this study, we constructed and screened HER2-nanobody verified tumor-suppressive cells. was established, filtrated, purified, demonstrated to inhibit cell total number, viability, colony formation mitosis, promote apoptosis cells vitro . Treated...
Abstract Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as exhibiting strong association with ERα signaling high specificity expression tissue. ERLC1 transcriptionally activated by ERα, stabilized ESR1 transcript sequestering miR-129 tethering FXR1 to maintain positive feedback loop that potentiated signaling. elevated...
Abstract It remains challenging for endoscopists to manage pancreaticobiliary diseases in patients with ectopic papilla of Vater by endoscopic retrograde cholangiopancreatography (ERCP). The present study sought evaluate the efficacy and safety ERCP this issue. Consecutive who underwent initial due were retrospectively analyzed. One hundred seven included. success rate cannulation was 83.2%. Endoscopic sphincterotomy, papillary balloon dilation, mechanical lithotripsy performed 12 (11.2%),...
Gastric cancer is one of the major malignancies with poor survival outcome. In this study, we reported that NUDT21 promoted cell proliferation, colony formation, migration and invasion in gastric cells. The expression levels were found to be much higher human tissues compared normal tissues. was positively correlated tumor size, lymph node metastasis clinical stage patients. High level associated overall (OS) rates also from patients those without metastasis. Moreover, forced cells growth...
The objective of this study is to measure the temporal changes in bronchial submucosal gland (SMG) cell proliferation sheep after smoke inhalation and burn (S+B) injury, assess effect bronchodilators on proliferative response. Archived main airways from S+B injury were immunostained for Ki67, percentage ciliated duct SMG cells expressing nuclear localization Ki67 was determined uninjured 24, 48, 72, 96 hours injury. A semiquantitative lining epithelial exfoliation made each tissue. Bronchial...
Abstract Addressing pancreaticobiliary disorders concomitant with gastroesophageal varices remains challenging. The goal of this study was to evaluate and compare the efficacy safety endoscopic retrograde cholangiopancreatography (ERCP) in cirrhotic noncirrhotic patients varices. We retrospectively analyzed data consecutive who underwent ERCP. Two hundred seventy ERCP procedures were performed on 208 patients. overall technical success rate 98.5%, no difference found between (98.7% vs 97.7%,...
The testicles and sperm are extremely susceptible to inflammation oxidative stress. Although Zhibai Dihuang Pill (ZDP) has been reported treat various infertilities including male infertility induced by Ureaplasma urealyticum (UU) infection, its mechanism is still poorly understood. This study aimed at clarifying the underlying of ZDP protect against UU-infected infertility. We found that infertile rats exhibited weight loss, reduced food intake, decreased count vitality. administration...
BACKGROUND Helicobacter pylori (H. ) is a prevalent pathogen associated with various diseases. Cholelithiasis also common condition. H. infection has been identified in the biliary system, suggesting its potential involvement However, specific role of development cholelithiasis remains inconclusive. AIM To investigate association between and cholelithiasis. METHODS We performed retrospective study more than 70000 subjects health examination center from 3 institutions middle, northern eastern...
Background Choledocholithiasis complicated with cholecystolithiasis is a common disease. This study explores novel strategy, called ERCP-based transcystic gallbladder-preserving cholecystolithotomy, for the simultaneous removal of bile duct stones and gallbladder stones. Methods From December 2018 to June 2021, all patients who met criteria preservation in our hospital were included prospectively followed up. Results We 48 patients, including 20 acute biliary pancreatitis. All successfully...
Abstract Background: Studies examining the safety of intravenous morphine use for acute heart failure (AHF) have reported inconsistent results. Objective: The comprehensive meta-analysis assessed and compared clinical outcomes in AHF. Methods: We formally searched electronic databases before June 2020 to identify potential studies. All trials were eligible inclusion if they or not patients with Results: 3 propensity-matched cohorts 2 retrospective analysis a total 151867 met criteria...
Introduction: Arginine vasopressin (AVP) is administered in sepsis to increase arterial pressure by activating AVP receptor 1 (V1R). Limited attention has been given effects of 2 (V2R) on endothelial cells. Previously, our ovine model sepsis, we have reported that treatment severe with V1R selective agonist prevents vascular hyper‐permeability as compared animals treated non‐selective AVP. We hypothesize V2R activation critically involved the pathogenesis hyper‐permeability, which a...
Objective To develop a new mirco-straw (named as LSL straw) for cryopreservation of few sperm retrieved from severe oligozoospermia and testicular biopsy samples.