A5070295826- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Machine Learning in Bioinformatics
- Sexual Differentiation and Disorders
- Histone Deacetylase Inhibitors Research
- Genomics and Phylogenetic Studies
- Hormonal Regulation and Hypertension
- Quantum Dots Synthesis And Properties
- Advanced Proteomics Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- RNA and protein synthesis mechanisms
- DNA Repair Mechanisms
- Chalcogenide Semiconductor Thin Films
- Genetics, Bioinformatics, and Biomedical Research
- Phase-change materials and chalcogenides
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Advanced Semiconductor Detectors and Materials
Shantou University Medical College
2020-2025
Shantou University
2020-2025
Arizona State University
2023-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
University of Miami
2024
Sylvester Comprehensive Cancer Center
2024
Cleveland Clinic Lerner College of Medicine
2016-2024
China University of Geosciences
2024
Cleveland Clinic
2015-2023
Histone methylation is a dynamic process that participates in diverse array of cellular processes and has been found to associate with cancer. Recently, several histone demethylases have identified catalyze the removal from H3 lysine residues. Through bioinformatic biochemical analysis, we JARID1B as H3K4 demethylase. Overexpression resulted loss tri-, di-, monomethyl but did not affect other methylations. In vitro experiments demonstrated directly catalyzes demethylation. The enzymatic...
Prostate cancer is driven by androgen stimulation of the receptor (AR). The next-generation AR antagonist, enzalutamide, prolongs survival, but resistance and lethal disease eventually prevail. Emerging data suggest that glucocorticoid (GR) upregulated in this context, stimulating expression AR-target genes permit continued growth despite blockade. However, countering mechanism administration GR antagonists problematic because essential for life. We show enzalutamide treatment human models...
After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral production from extragonadal precursors that activate the receptor pathway. 3β-Hydroxysteroid dehydrogenase-1 (3βHSD1) is rate-limiting enzyme for synthesis, which together lead to CRPC. Here, we show cancer-associated fibroblasts (CAFs) increased epithelial 3βHSD1 expression, induced activated receptor, and Unbiased metabolomics revealed CAF-secreted glucosamine specifically 3βHSD1....
Prostate cancer is highly dependent on androgens and the androgen receptor (AR). Hormonal therapies inhibit gonadal testosterone production, block extragonadal biosynthesis, or directly antagonize AR. Resistance to medical castration occurs as castration-resistant prostate (CRPC) driven by reactivation of androgen-AR axis. 3β-hydroxysteroid dehydrogenase-1 (3βHSD1) serves rate-limiting step for potent synthesis from precursors, thereby stimulating CRPC. Genetic evidence in men demonstrates...
Progression of prostate cancer depends on androgen receptor, which is usually activated by androgens. Therefore, a mainstay treatment deprivation therapy. Unfortunately, despite initial response, resistance nearly always develops, and disease progresses to castration-resistant (CRPC), remains driven non-gonadal androgens synthesized in tissues. 3β-Hydroxysteroid dehydrogenase/Δ5-->4 isomerase 1 (3βHSD1) catalyzes the rate-limiting step synthesis. However, how 3βHSD1, especially...
Epigenomic abnormalities caused by genetic mutation in epigenetic regulators can result neurodevelopmental disorders, deficiency neural plasticity and mental retardation. As a histone demethylase, plant homeodomain finger protein 8 (Phf8) is candidate gene for syndromal non-specific forms of X-chromosome-linked intellectual disability (XLID). Here we report that Phf8 knockout mice displayed impaired learning memory, hippocampal long-term potentiation (LTP) without gross morphological...
Background Recent impressive advances in cancer immunotherapy have been largely derived from cellular immunity. The role of humoral immunity carcinogenesis has less understood. Based on our previous observations we hypothesize that an immunoglobulin subtype IgG4 plays essential immune evasion. Methods distribution, abundance, actions, properties and possible mechanisms were investigated with human samples animal tumor models extensive array techniques both vitro vivo. Results In a cohort...
Abstract Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which leads to limited interference strategies therapy. Here we characterized the clinical relevance, significance, and regulation mechanism of enzyme HSD17B2 in Experimental Design: expression was detected with patient specimens cell lines. Function steroidogenesis, androgen receptor (AR) signaling, tumor growth lines a xenograft...
Purpose: A major mechanism of castration-resistant prostate cancer (CRPC) involves intratumoral biosynthesis dihydrotestosterone (DHT) from adrenal precursors. We have previously shown that adrenal-derived androstenedione (AD) is the preferred substrate over testosterone (T) for 5α-reductase expressed in metastatic CRPC, bypassing T as an obligate precursor to DHT. However, metabolic pathway DHT has not been rigorously investigated setting primary disease prostate.Experimental Design:...
Inhibiting H6PD restores prostate cancer response to AR antagonists by normalizing glucocorticoid metabolism in mouse xenograft models.
The slow Li
Abstract Androgen deprivation therapy suppresses tumor androgen receptor (AR) signaling by depleting circulating testosterone and is a mainstay treatment for advanced prostate cancer. Despite initial response, castration-resistant cancer nearly always develops remains driven primarily the axis. Here we investigated how changes in oxygenation affect synthesis. In cells, chronic hypoxia coupled to reoxygenation resulted efficient metabolism of precursors produce androgens activate AR. Hypoxia...
We have investigated the Raman scattering and photoluminescence (PL) of mixed crystals grown by MBE, covering entire composition range . The results studies show that display two-mode behaviour. In addition, spectra obtained in backscattering edge-emission geometries, reflectivity temperature dependence been employed to find out origin PL emissions with different x values. indicate emission bands, for samples small values, can be related band gap transitions or a shallow-level centre, while...
Abstract Sequence alignment is an essential method in bioinformatics and the basis of many analyses, including phylogenetic inference, ancestral sequence reconstruction, gene annotation. Sequencing artifacts errors made during genome assembly, such as abiological frameshifts incorrect early stop codons, can impact downstream analyses leading to erroneous conclusions comparative functional genomic studies. More significantly, while indels occur both within between codons natural sequences,...