A5091676865- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Silicon and Solar Cell Technologies
- Thin-Film Transistor Technologies
- Cancer, Hypoxia, and Metabolism
- Silicon Nanostructures and Photoluminescence
- Hormonal Regulation and Hypertension
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Radiopharmaceutical Chemistry and Applications
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Mass Spectrometry Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Traffic and Road Safety
- Heat shock proteins research
- Neurogenetic and Muscular Disorders Research
- Ubiquitin and proteasome pathways
- Botulinum Toxin and Related Neurological Disorders
- Steroid Chemistry and Biochemistry
- Glutathione Transferases and Polymorphisms
Tianjin University
2025
Chinese Academy of Sciences
2011-2024
Center for Excellence in Molecular Cell Science
2011-2024
University of Chinese Academy of Sciences
2017-2024
Jiangsu Hengrui Medicine (China)
2024
Hebei Medical University
2012-2023
Shanghai Institute of Microsystem and Information Technology
2018-2023
Second Hospital of Hebei Medical University
2012-2023
Tongji University
2009-2023
Tongji Hospital
2020-2023
Abstract Recent achievements in amorphous/crystalline silicon heterojunction (SHJ) solar cells and perovskite/SHJ tandem place hydrogenated amorphous (a-Si:H) at the forefront of photovoltaics. Due to extremely low effective doping efficiency trivalent boron tetravalent silicon, light harvesting aforementioned devices is limited by their fill factors (FFs), a direct metric charge carrier transport. It challenging but crucial develop highly conductive doped a-Si:H with minimal FF losses. Here...
Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the of H4K20 monomethylation (H4K20me-1) regulation remains unclear. Here, we show that Wnt3a specifically stimulates at T cell factor (TCF)-binding element through histone methylase SET8. Additionally, SET8 is crucial for activation Wnt reporter gene target genes both mammalian cells zebrafish. Furthermore, interacts with lymphoid enhancing factor-1 (LEF1)/TCF4 directly, this...
Prostate cancer is driven by androgen stimulation of the receptor (AR). The next-generation AR antagonist, enzalutamide, prolongs survival, but resistance and lethal disease eventually prevail. Emerging data suggest that glucocorticoid (GR) upregulated in this context, stimulating expression AR-target genes permit continued growth despite blockade. However, countering mechanism administration GR antagonists problematic because essential for life. We show enzalutamide treatment human models...
Ubiquitination plays important and diverse roles in modulating protein functions.As a C2-WW-HECT-type ubiquitin ligase, Smad ubiquitination regulatory factor 1 (Smurf1) commonly serves to regulate ubiquitin-dependent degradation number of signaling pathways.Here, we report novel function Smurf1 regulating Wnt/-catenin through targeting axin for nonproteolytic ubiquitination.Our data unambiguously demonstrate that ubiquitinates Lys 29 (K29)-linked polyubiquitin chains.Unexpectedly,...
Abstract Silicon‐based photovoltaic (PV) modules suffer from potential‐induced degradation (PID) caused by sodium (Na) permeation, which is present in large quantities soda‐lime glass. Here, we report that Na atoms can decrease the performance of amorphous/crystalline silicon heterojunction (SHJ) solar cells without help a voltage bias. The three stages are investigated this work. First, H 2 O molecules open channels for transport transparent conductive oxide (TCO), while device remains...
Steroid hormones are essential in stress response, immune system regulation, and reproduction mammals. Steroids with 3-oxo-Δ4 structure, such as testosterone or progesterone, catalyzed by steroid 5α-reductases (SRD5As) to generate their corresponding 3-oxo-5α steroids, which for multiple physiological pathological processes. SRD5A2 is already a target of clinically relevant drugs. However, the detailed mechanism SRD5A-mediated reduction remains elusive. Here we report crystal structure...
Strategies for patient stratification and early intervention are required to improve clinical benefits patients with prostate cancer. Here, we found that active DHEA utilization in the gland correlated tumor aggressiveness at disease stages, 3βHSD1 inhibitors were promising intervention. [3H]-labeled consumption was traced fresh prostatic biopsies ex vivo. Active more frequently metastatic or therapy-resistant disease. Genetic transcriptomic features associated potency of analyzed generate...
Comparing with conventional lithium-ion batteries organic electrolyte, aqueous zinc-ion low cost, sustainable and environment-friendly cathodes exhibit promising potential to meet the continuously increasing demand on safe large-scale energy storage. The representative cathodes, including quinoidal polycyclic aromatic hydrocarbons (PAHs) 2,2,6,6-tetramethylpiperidinyl-N-oxyl (TEMPO) polymers, suffer from challenging synthesis limited theoretical specific capacity. Herein, different PAHs...
Abstract Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which leads to limited interference strategies therapy. Here we characterized the clinical relevance, significance, and regulation mechanism of enzyme HSD17B2 in Experimental Design: expression was detected with patient specimens cell lines. Function steroidogenesis, androgen receptor (AR) signaling, tumor growth lines a xenograft...
Prostate cancer continuously progresses following deprivation of circulating androgens originating from the testis and adrenal glands, indicating existence oncometabolites beyond androgens. In this study, mass-spectrometry-based screening clinical specimens a retrospective analysis on data prostate patients indicate potential oncogenic effects progesterone in patients. High doses activate canonical non-canonical androgen receptor (AR) target genes. Physiological levels facilitate cell...
Novel strategies for prostate cancer therapy are required to overcome resistance abiraterone and enzalutamide. Here, we show that increasing 3βHSD1 after enzalutamide treatment is essential drug resistance, biochanin A (BCA), as an inhibitor of 3βHSD1, overcomes resistance. activity increases in cell lines, biopsy samples, patients long-term with or abiraterone. Enhanced steroidogenesis, mediated by sufficient impair function. In patients, accelerated metabolism results a decline plasma...
Proliferation of the neural/neuronal progenitor cells (NPCs) at ventricular zone dorsal spinal cord requires stimuli Wnt and bone morphogenic protein (BMP). However, how these two signaling pathways are regulated to initiate differentiation in NPCs as they enter intermediate is not known. Here, we show that Smad6, a negative regulator BMP signaling, expressed chick cord. Knockdown experiments Smad6 required for promoting exit cell cycle differentiate into neurons. Although find inhibits...