A5026364190- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- Statistical Methods and Inference
- Probability and Risk Models
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Financial Risk and Volatility Modeling
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Statistical Distribution Estimation and Applications
- Bladder and Urothelial Cancer Treatments
- DNA Repair Mechanisms
- Genital Health and Disease
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Ferroptosis and cancer prognosis
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Renal cell carcinoma treatment
- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
Hubei Normal University
2025
Beijing Anzhen Hospital
2025
Capital Medical University
2025
Tongji University
2024
Fudan University Shanghai Cancer Center
2018-2024
Shanghai Medical College of Fudan University
2018-2024
Shanghai Cancer Institute
2022-2024
Northeastern University
2024
Changhai Hospital
2024
Second Military Medical University
2024
Significance Recent studies have established that metabolic restrains, such as glucose restriction, impair the activities of effector T cells in tumor microenvironment. In same context, a huge expansion activated Treg tissues has been described mice and humans, contributing to suppression protective antitumor immunity. Our data demonstrate Tregs are committed survive proliferate hostile milieu thanks advantage based on combination glycolysis fatty acid synthesis oxidation. This allows...
Background: PSMA-negative but FDG-positive (PSMA−/FDG+) lesion in dual-tracer ( 68 Ga-PSMA and 18 F-FDG) positron emission tomography/computed tomography (PET/CT) is associated with an unfavorable response to Lutetium-177 177 Lu)-PSMA-617. This study sought develop both radiomics clinical models for the precise prediction of presence PSMA−/FDG+ lesions patients castration-resistant prostate cancer (CPRC). Methods: A cohort 298 who underwent PET/CT a less than 5-day interval was included. The...
Elevated pregnancy hormone levels, such as oestrogen and progesterone, may increase the risk of developing breast cancer both in mothers offspring. However, reasons for large inter-individual variations estrogen progesterone levels during remain unknown. The objectives this study were to investigate whether a) intakes total dietary fat, types fat (monounsaturated: MUFA, polyunsaturated: n-3 n-6 PUFA, saturated) b) gestational weight gain are associated with estradiol plasma pregnancy.We...
Introduction Hepatic fibrosis (HF), a progressive chronic liver disease, is serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There growing evidence that natural products might provide safe interventions HF. Among them, rhaponticin (RHA), stilbenoid glucoside product isolated from medicinal plants Rheum L. Polygonaceae Juss. many pharmacological activities such as anti-inflammatory,...
Bacillus cereus, a well-known foodborne pathogen, poses an increased risk because of its ability to form biofilms. In this study, we evaluated the antibacterial and antibiofilm activities Toona sinensis extracts against B. cereus. All tested T. varieties demonstrated significant activity with inhibition zone diameters exceeding 11 mm (P < 0.05). Notably, from Sichuan Dazhu exhibited strong effects, even antibiotic-resistant cereus strains. 239 compounds were identified in by LC-MS. The MIC...
Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop validate nomograms predict lymph (LNM) LIM patients with carcinoma.A total 32,819 who underwent surgery for pT1 or pT2 carcinoma were enrolled study based on their records SEER database. Risk factors LNM assessed univariate multivariate binary logistic regression. The C-index calibration plots used evaluate model discrimination. predictive accuracy...
Germline DNA damage repair (DDR) deficiency has been associated with increased cancer risk, poor prognosis and therapeutic opportunity for prostate (PCa) patients. However, the landscape of germline mutations in PCa covering comprehensive DDR genes not reported. We performed whole-exome sequencing 246 patients who meet National Cancer Center Network guidelines genetic testing analyzed variants 276 genes, which was from Genome Atlas. A total 79 deleterious alterations 60 were identified 31%...
Programmed cell death 1 ligand 1), programmed protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3, lymphocyte activation gene-3, ITIM domain (TIGIT) are considered major immune co-inhibitory receptors (CIRs) the most promising immunotherapeutic targets in cancer treatment, but they largely unexplored upper tract urothelial carcinoma (UTUC). The aim of this Cohort Study was to provide evidence concerning expression profiles clinical...