A5100323815- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Oral Health Pathology and Treatment
- Advanced Polymer Synthesis and Characterization
- Polymer composites and self-healing
- Electrospun Nanofibers in Biomedical Applications
- Block Copolymer Self-Assembly
- Liquid Crystal Research Advancements
- Bioactive Natural Diterpenoids Research
- Flame retardant materials and properties
- Nanoparticles: synthesis and applications
- Synthesis and properties of polymers
- Congenital heart defects research
- Gastrointestinal Tumor Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Carbon and Quantum Dots Applications
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Wave and Wind Energy Systems
- Chemical Synthesis and Analysis
- Polymer Nanocomposites and Properties
- 3D Printing in Biomedical Research
- Congenital Heart Disease Studies
- interferon and immune responses
Shanghai Jiao Tong University
2014-2024
XinHua Hospital
2015-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Baotou Medical College
2023
Inner Mongolia University of Science and Technology
2023
Shanghai Institute of Hematology
2011-2021
Shanghai Ninth People's Hospital
2017-2021
Guangxi Medical University
2021
Soochow University
2018-2021
Adrenal Cushing’s syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders. We performed whole-exome sequencing 49 blood-tumor pairs RNA 44 cortisol-producing adenomas (ACAs), adrenocorticotropic hormone–independent macronodular hyperplasias (AIMAHs), oncocytomas (ADOs). identified a hotspot in the PRKACA gene with L205R mutation 69.2% (27 out 39) ACAs validated 65.5% total 87 ACAs. Our data revealed that...
Abstract Vascularization and efficient perfusion are long-standing challenges in cardiac tissue engineering. Here we report engineered perfusable microvascular constructs, wherein human embryonic stem cell-derived endothelial cells (hESC-ECs) seeded both into patterned microchannels the surrounding collagen matrix. In vitro, hESC-ECs lining luminal walls readily sprout anastomose with de novo-formed tubes matrix under flow. When implanted on infarcted rat hearts, microvessel grafts integrate...
Abstract Early warning of tumor formation is crucial for the classification, treatment, and prognosis patients. Here, a new strategy reported, aimed at realizing this goal based on imaging aerobic glycolysis processes using nitrogen‐doped carbon dots (N‐CDs) as fluorescent probes. The intensity photoluminescence emitted by N‐CDs specifically enhanced nicotinamide adenine dinucleotide (NAD + , oxidized) in physiological environment. allow few (five to ten) abnormal cells spontaneous...
AIM To evaluate the effects of various methods small bowel preparation on quality visualization and gastrointestinal transit time capsule endoscopy (CE). METHODS Ninety patients referred for CE were prospectively randomized to three equal groups according used: (a) a control group, in which requested drink 1 L clear liquids only, 12 h before examination; (b) purgative ingest polyethylene glycol (PEG)/electrolyte solution or (c) combined with simethicone group (P-S group), PEG, examination,...
This study reports a novel super-hydrophobic surface with fluorinated cross-linked poly[cyclotriphosphazene-co-(4,4'-(hexafluoroisopropylidene)diphenol)] microspheres prepared via single-step precipitation polymerization and simple dip-coating route.
Abstract Background and Aim: Since its introduction, capsule endoscopy (CE) has made it possible to visualize the small intestine mucosa directly. However, owing limited battery life, only 60–80% of capsules could reach cecum would possibly affect diagnostic yield. The aim this study was determine effect oral mosapride on gastrointestinal transit time yield CE. Method: Sixty patients were involved in randomized, prospective controlled study. randomly allocated groups receiving either citrate...
We recently demonstrated that oridonin could induce apoptosis and senescence of colon cancer cells in vitro vivo. However, the underlying mechanism remains unknown. In this study, involvement reactive oxygen species oridonin-induced cell death was investigated adenocarcinoma-derived SW1116 cells. Oridonin increased intracellular hydrogen peroxide levels reduced glutathione content a dose-dependent manner. N-acetylcysteine, scavenger, not only blocked increase depletion, but also induced by...
The distinct antibacterial mechanism of vertical graphene Si toward bacteria. Vertical kills Gram-positive bacteria through physical disruption and substrate Gram-negative by extracting electrons from bacterial membranes.
Tissue engineering approaches combine a bioscaffold with stem cells to provide biological substitutes that can repair bone defects and eventually improve tissue functions. The prospective should have good osteoinductivity. Surface chemical roughness modifications are regarded as valuable strategies for developing bioscaffolds because of their positive effects on enhancing osteogenic differentiation. However, the synergistic combination two is currently poorly studied. In this work,...
Tissue engineering technology that adopts mesenchymal stem cells combined with scaffolds presents a promising strategy for tissue regeneration. Human adipose-derived (hADSCs) have attracted considerable attention in bone their osteogenic potential. The extracellular matrix (ECM) is critical the cell niche as physical support and known to be able maintain properties. In this study, ECM derived from ADSCs was produced termed ADM. ADM demonstrated markedly promote proliferation of marrow...
Polyetheretherketone (PEEK), particularly its sulfonated form (SPEEK), has emerged as a promising synthetic biomaterial for artificial bone implants, providing an alternative to conventional titanium metal. However, postoperative infections pose critical challenge, driven by diverse and antibiotic-resistant bacteria. To address this issue, we propose the modification of SPEEK surface using thin graphene oxide (GO) film containing silver (Ag) ions. The resulting coating exhibits substantial...
Synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9(11)-dien-28-oate (CDDO-Me) has been shown as a promising agent against ovarian cancer. However, the underlying mechanism is not well understood. Here, we demonstrate that CDDO-Me directly interacts with Hsp90 in cells by cellular thermal shift assay. treatment leads to upregulation of Hsp70 and degradation clients (ErbB2 Akt), indicating inhibition cells. Knockdown significantly inhibits cell proliferation enhances...
Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to pathogenesis certain diseases including cancers, especially acute promyelocytic leukemia (APL). Recently, oridonin, a natural diterpenoid isolated from Rabdosia rubescens, was demonstrated regulate by increasing its protein level. However, underlying molecular mechanism for this action has not been...
A biomimetic nanofibrous membrane can immobilize growth factors or agents to obtain sustained release and prolonged effect in tissue engineering.
Abstract All‐solid‐state polymer electrolyte‐based rechargeable batteries paired with high‐voltage cathodes and lithium anodes hold promising prospects to increase the energy density safety of metal (LMBs). To improve stability electrolytes at both positive negative electrodes, fluorinated have been designed synthesized by copolymerization epoxide monomers containing cyclic carbonates moieties. The possessing a large dielectric constant endow high salt solubility. While, introduction...
This study reports a noncovalent functionalization of MWCNTs with fluorinated cross-linked polymer coating poly[cyclotriphosphazene-co-(4,4′-(hexafluoroisopropylidene)diphenol)] and their application as the support Pt for electrocatalytic oxidation methanol.
Polypropylene (PP) is one of the most widely used polymers in many areas. But it also has some drawbacks. In this work, a novel nanomaterial — zinc oxide-doped graphene (G-nZnO) was melt-blended with PP to prepare an antibacterial nanocomposite. It found that mechanical properties, thermal stability and barrier properties nanocomposites reached highest value when content G-nZnO 0.2[Formula: see text]phr. The tensile were 36% higher than those pure PP, increased by 113%. results tests showed...
Abstract Endometrial receptivity is a prerequisite for the success of assisted reproduction. Patients with consistently thin endometrium frequently fail to conceive, owing low endometrial receptivity, and there are currently very few therapeutic options available. Our previous study demonstrated that intrauterine granulocyte-macrophage colony-stimulating factor (GM-CSF) administration resulted in significant improvement clinical pregnancy implantation rates was an effective means increasing...
Abstract An amine‐terminated curing agent for epoxy resin based on hexachlorocyclotriphosphazene was synthesized. Its chemical structure characterized by 1 H‐NMR, FT‐IR, and elemental analysis. The temperature determined differential scanning calorimeter. thermal stability, hydrophobicity, flame retardancy, insulation property of the cured as‐prepared were superior to those 4,4′‐diaminodiphenylsulfone. new obtained best heat‐moisture resistance when ratio amino protons group 1.2 : 1. reached...