A5012310610- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Fungal and yeast genetics research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Amino Acid Enzymes and Metabolism
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
Peking University
2024
State Key Laboratory of Membrane Biology
2024
Fudan University Shanghai Cancer Center
2023
Shanghai Medical College of Fudan University
2023
Shanghai Cancer Institute
2023
Zhejiang University
2023
Abstract Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria nitrogenic anabolism. In particular, decreases cellular SAM constrain lipoate metabolism and protein lipoylation required for operation tricarboxylic acid (TCA) cycle mitochondria,...
A novel form of cell death, cuproptosis, was recently identified to be mediated by the binding copper lipoylated enzymes tricarboxylic acid cycle. Cuproptosis-related genes (CRGs) may play a crucial role in progression pancreatic adenocarcinoma (PAAD), which often exhibits metabolic reprogramming. In present study, univariate Cox regression analysis and Kaplan-Meier survival were performed identify prognostic CRGs. Data from Cancer Therapeutics Response Portal Genomics Drug Sensitivity...
The abilities of an organism to cope with extrinsic stresses and activate cellular stress responses decline during aging. signals that modulate in aged animals remain be elucidated. Here, we discover feeding Caenorhabditis elegans (C. elegans) embryo lysates adult worms enabled the mitochondrial unfolded protein response (UPR