A5051557621- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Genetics, Aging, and Longevity in Model Organisms
- Green IT and Sustainability
- Energy Harvesting in Wireless Networks
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Advanced Battery Technologies Research
Peking University
2018-2024
State Key Laboratory of Membrane Biology
2023-2024
Center for Life Sciences
2018-2023
Beijing Advanced Sciences and Innovation Center
2023
Sichuan University
2013
Dalian University of Technology
2011
N6-Methyldeoxyadenine (6mA) has been rediscovered as a DNA modification with potential biological function in metazoans. However, the physiological and regulatory mechanisms regarding establishment, maintenance removal of 6mA eukaryotes are still poorly understood. Here we show that genomic levels change response to pathogenic infection Caenorhabditis elegans (C. elegans). We further identify METL-9 methyltransferase catalyzes modifications upon pathogen infection. Deficiency impairs...
With the rapid development of new and innovative applications for mobile devices like smart phones, advances in battery technology have not kept pace with rapidly growing energy demands. Thus consumption has become a more important issue devices. To meet requirements saving energy, it is critical to monitor analyze on phones. For this purpose, we develop monitoring system called SEMO phones using Android operating system. It can profile usage information, which vital both developers users.
While N 6 -methyldeoxyadenine (6mA) modification is a fundamental regulation in prokaryotes, its prevalence and functions eukaryotes are controversial. Here, we report 6mA-Sniper to quantify 6mA sites at single-nucleotide resolution, delineate profile Caenorhabditis elegans with 2034 sites. Twenty-six of 39 events Mnl I restriction endonuclease were verified, demonstrating the feasibility this method. The levels pinpointed by generally increased after Pseudomonas aeruginosa infection, but...
The abilities of an organism to cope with extrinsic stresses and activate cellular stress responses decline during aging. signals that modulate in aged animals remain be elucidated. Here, we discover feeding Caenorhabditis elegans (C. elegans) embryo lysates adult worms enabled the mitochondrial unfolded protein response (UPR
ABSTRACT While N 6 -methyldeoxyadenine (6mA) modification has been linked to fundamental regulatory processes in prokaryotes, its prevalence and functional implications eukaryotes are controversial. Here, we report 6mA-Sniper quantify 6mA sites at single-nucleotide resolution. With 6mA-Sniper, delineated an accurate profile C. elegans with 2,034 sites, significantly enriched on sequences of [GC]G A G motif. Twenty-six 39 events MnlI restriction endonuclease were experimentally verified,...