A5055586964- Hydraulic Fracturing and Reservoir Analysis
- Hydrocarbon exploration and reservoir analysis
- Reservoir Engineering and Simulation Methods
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Graphene research and applications
- Epigenetics and DNA Methylation
- Molecular Junctions and Nanostructures
- Advanced Thermoelectric Materials and Devices
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Innovation Diffusion and Forecasting
- Enhanced Oil Recovery Techniques
- Plant-derived Lignans Synthesis and Bioactivity
- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Oil and Gas Production Techniques
- Immune Response and Inflammation
- Gold and Silver Nanoparticles Synthesis and Applications
- Drilling and Well Engineering
- Biomedical Research and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- Magnolia and Illicium research
- NF-κB Signaling Pathways
- Nanoplatforms for cancer theranostics
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
Hebei University of Technology
2024
Central South University of Forestry and Technology
2023
Central South University
2023
Tianjin Medical University
2017-2021
Harvard University
1993
Abstract miR-21 is aberrantly expressed, and plays a role in various types of tumors many other diseases. However, the mechanism LPS-induced septic shock still unclear. In this study, we investigated pyroptosis shock. Here, show that deficiency inhibited NLRP3, ASC, caspase-1 expression, as well inflammasome activation myeloid cells from both mice humans. We found NF-κB pathway was regulated by miR-21, A20 direct target miR-21. Furthermore, ASC pyroptosome, which restrained GSDMD cleavage,...
Background Immune checkpoint blockade has emerged as a potential cancer immunotherapy. The “don’t eat me” signal CD47 in cells binds regulatory protein-α on macrophages and prevents their phagocytosis. role of miR-340 pancreatic ductal adenocarcinoma (PDAC), especially tumor immunity, not been explored. Here, we examined the clinical biological relevance molecular pathways regulated by PDAC. Methods expression relationship with patient survival were analyzed bioinformatics. mechanism action...
Pancreatic cancer is an aggressive malignancy that unresponsive to conventional radiation and chemotherapy. Therefore, development of novel immune therapeutic strategies urgently needed. L-4F, Apolipoprotein A-I (ApoA-I) mimetic peptide, engineered mimic the anti-inflammatory anti-oxidative functionalities ApoA-I. In this work, H7 cells were orthotopically implanted in C57BL/6 mice treated with L-4F. Then, pancreatic progression inflammatory microenvironment investigated vivo. The...
Common fragile sites (CFSs) are specific breakage-prone genomic regions and present frequently in cancer cells. The (E2-independent) E3 ubiquitin-conjugating enzyme FATS (fragile site-associated tumor suppressor) has antitumor activity cells, but the function of immune cells is unknown. Here, we report a development via regulation immunity. Fats-/- mice show reduced subcutaneous B16 melanoma H7 pancreatic growth compared with WT controls. macrophage dependent associated phenotypic shift...
Abstract Background Metabolic reprogramming contributes to bladder cancer development. This study aimed understand the role of SLC7A5 in cancer. Methods We systematically analyzed correlation between and through various approaches, including bioinformatics, western blotting, cell cycle analysis, proliferation assays, invasion experiments. also investigated immunological features within tumor microenvironment (TME), encompassing immune cycles, modulators, checkpoints, tumor-infiltrating cells...
The thermoelectric transport properties of four kinds DNA bases sandwiched between two zigzag-edge graphene nanoribbon electrodes are investigated by first-principles calculation. modulation quantum interference, molecular length, and torsion on studied. It is found that the thermopower efficiency can be obviously enhanced in guanine electrode coupling geometry manifests a interference effect. A decrease with number has been found, while efficiencies have different trend increase molecules....
Abstract Acute peritonitis is an acute inflammatory response of the peritoneal cavity to physical injury and chemical stimulation. Timely resolution this critical prevent further damage body, which can eventually lead more severe chronic inflammation. Arctigenin (ATG) main active ingredient Chinese medicine Arctium lappa . In recent years, there have been increasing number studies on anti‐inflammatory effect ATG, but few ATG inflammation, especially in peritonitis, has not reported. study, a...
Infrared spectroscopy can accurately reflect the information of molecular vibration, and it is an important technology to characterize composition structure materials. However, since interaction between nanomaterials infrared light very weak due significant size mismatch, challenging obtain spectral in field spectroscopy. The plasmon a collective electron oscillation on surface material inducing by incident light, has excellent confinement, which significantly enhance nanomaterials. Graphene...
In order to study the stress sensitivity of tight sand reservoir and evaluate their impact on productivity, physical mathematical simulation is carried out under scanning electron microscopy (SEM), casting thin sections test technology. The results show that porosity permeability decreases with pressure, damage mode can be described as "Falling quickly then falling slowly." relative loss rate from 4.88% 8.46%, meanwhile, has stronger 63.86% 86.14%. connected microscopic pore structure, size...
The determination of dynamic reserves is important for tight sandstone gas reservoirs in production. Based on the geological and data Yan'an field, influence pressure properties natural studied by mathematical methods. At same time, modified flowing material balance equation established considering changes viscosity compressibility. result shows that (1) increases rapidly with pressure; (2) deviation factor decreases (P < 15 MPa) then > temperature; (3) compressibility (4) compared results...
The determination of dynamic reserves is an important basis for rational production allocation. Based on the Yan’an Gas Field, modified flowing material balance equation established considering changes gas viscosity and compressibility. At same time, a reasonable allocation method wells developed. result shows: ① μ gCg decreases with pressure increases temperature. ② error smaller compared flow method, 1.25 %. ③ great change will affect accuracy especially shut-in long time before drop...
Abstract Based on static geology and dynamic production of typical wells in Yan'an gas field, a convenient method the controlled reserves was established combining with material balance (MB). The applied to 88 tight field. results show that: ①Controlled by pore structure, are divided into three types based morphology capillary pressure curve analysis parameter characteristics, their productivity is evaluated, respectively. ②The flow (FMB) ignores change natural compressibility, viscosity Z...
The thermoelectric transport properties of four kinds DNA bases sandwiched between two zigzag-edge graphene nanoribbon electrodes are investigated by first-principles calculation.The modulation quantum interference, molecular length, and torsion on studied.It is found that the thermopower efficiency can be obviously enhanced in guanine electrode coupling geometry manifests a interference effect. A decrease with number has been found, while efficiencies have different trend increase...
Abstract The determination of dynamic reserves gas well is an important basis for rational production allocation and development a single well. commonly used flow material balance method (FMB method) uses the slope curve wellhead pressure cumulative after stable to replace average formation calculate controlled However, based on theoretical calculation, FMB ignores change natural compression coefficient, viscosity deviation coefficient in process. After considering these changes,...