A5007828642- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Electronic Health Records Systems
- Healthcare Systems and Technology
- Retinal Development and Disorders
- Virus-based gene therapy research
- Machine Learning in Healthcare
- Mobile Health and mHealth Applications
- Parkinson's Disease Mechanisms and Treatments
- Inflammatory Bowel Disease
- Biomedical Text Mining and Ontologies
- Child and Adolescent Psychosocial and Emotional Development
- Colorectal Cancer Screening and Detection
- Pharmaceutical studies and practices
- Clinical practice guidelines implementation
- Healthcare Technology and Patient Monitoring
- Renal Diseases and Glomerulopathies
- Balance, Gait, and Falls Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Neurological disorders and treatments
- Context-Aware Activity Recognition Systems
- Bayesian Modeling and Causal Inference
- Meta-analysis and systematic reviews
IBM (United States)
2017-2024
Cambridge Scientific (United States)
2020-2024
University of Colorado Denver
2023
University of Oulu
2020-2023
Helmholtz Zentrum München
2021-2023
University of Colorado Anschutz Medical Campus
2021-2023
Lund University
2021-2023
Computational Physics (United States)
2022-2023
Pacific Northwest Diabetes Research Institute
2023
Oulu University Hospital
2023
Recombinant adeno-associated virus (rAAV) is a promising vector for therapy of retinal degenerative diseases. We evaluated the efficiency, cellular specificity, and safety cell transduction in nonhuman primates after subretinal delivery an rAAV carrying cDNA encoding green fluorescent protein (EGFP), rAAV. CMV.EGFP. The treatment results efficient stable EGFP expression lasting >1 year. Transgene neural retina limited exclusively to rod photoreceptors. There neither electroretinographic nor...
Recombinant adeno-associated virus (rAAV) is a promising vector for retinal application as it transduces photoreceptors and pigment epithelium cells efficiently in stable fashion. Because rAAV also ganglion cells, we reasoned that ocular of might result delivery transgenic protein to the CNS. Here describe high levels green fluorescent (GFP) persisting at least 6 months optic nerves brains mice dogs after intravitreal rAAV–GFP. There was no clinical or histological evidence inflammatory...
Clinical researchers use disease progression models to understand patient status and characterize patterns from longitudinal health records. One approach for modeling is describe using a small number of states that represent distinctive distributions over set observed measures. Hidden Markov (HMMs) its variants are class both discover these make inferences patients. Despite the advantages algorithms discovering interesting patterns, it still remains challenging medical experts interpret...
OBJECTIVE To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity progression to clinical diabetes. RESEARCH DESIGN AND METHODS For cohorts in Finland, Germany, Sweden, the U.S., 24,662 children at increased genetic for development autoantibodies type 1 diabetes have been followed. Following outcomes were analyzed 16,709 infants-toddlers enrolled age 2.5 years. RESULTS In infant-toddler cohort, 1,413 (8.5%) developed least one...
A retrospective analysis of 1324 eyes showed a statistically significant influence the extracapsular approach in preventing aphakic retinal detachment (ARD) and propensity for high myopes containing iris clip lenses to develop ARD.After exclusion association with vitreous loss ARD occurred l 9% 482 control intracapsular eyes, 4 8% 185 (both groups having mean follow-up 1 years), I1 1N% 72 highly myopic one 46 none 439 nonmyopic eyes.
BACKGROUND AND OBJECTIVE: Implementing US Preventive Services Task Force and American Academy of Pediatrics preventive service guidelines within the short duration a visit is difficult because identifying which large number apply to particular patient impractical. Clinical decision support system integrated with electronic medical records offer good strategy for implementing screening in waiting rooms. Our objective was determine rates positive risk screens during typical well-care visits...
To determine if implementing attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment guidelines in a clinical decision support system would result better care, including higher rates of adherence to care guidelines.We conducted cluster randomized controlled trial which we compared management ADHD 6- 12-year-olds after implementation computer 4 practices.Eighty-four charts were reviewed. In the control group, use structured diagnostic assessments dropped from 50% baseline...
To determine if automated screening and just in time delivery of testing referral materials at the point care promotes universal rates for maternal depression.The Child Health Improvement through Computer Automation (CHICA) system is a decision support electronic medical record used our pediatric clinics. All families patients up to 15 months age seen between October 2007 July 2009 were randomized one three groups: (1) questions printed on prescreener forms (PSF) completed by mothers waiting...
Clinical guidelines are prevalent but frequently not used. Computer reminder systems can improve adherence to have been widely adopted. We present a computer-based decision support system that combines these elements: 1) pediatric preventive care encoded in Arden Syntax; 2) dynamic, scannable paper user interface; and 3) HL7-compliant interface existing electronic medical record systems. The result is both delivers “just time” patient-relevant physicians during the...
IMPORTANCE Developmental delays and disabilities are common in children.Research has indicated that intervention during the early years of a child's life positive effect on cognitive development, social skills behavior, subsequent school performance.OBJECTIVE To determine whether computerized clinical decision support system is an effective approach to improve standardized developmental surveillance screening (DSS) within primary care practices. DESIGN, SETTING, AND PARTICIPANTSIn this...
Abstract Development of islet autoimmunity precedes the onset type 1 diabetes in children, however, presence autoantibodies does not necessarily lead to manifest disease and clinical symptoms is hard predict. Here we show, by longitudinal sampling (IAb) insulin, glutamic acid decarboxylase antigen-2 that progression follows distinct trajectories. Of combined Type Data Intelligence cohort 24662 participants, 2172 individuals fulfill criteria two or more follow-up visits IAb positivity at...
In the past 5 yr, advances in technology have been made that allow efficient somatic transfer of functional genes to target cells eye vivo. The ability deliver these is due primarily development viral vectors-viruses which various replicative functions replaced with transgene cassettes. Because progress continues developing new vectors and refining those are already available, field has moved step actually proving gene possible one where used (experimentally) for therapeutic purposes. fact,...
The Child Health Improvement through Computer Automation (CHICA) system is a decision-support and electronic-medical-record for pediatric health maintenance disease management. purpose of this study was to explore CHICA's ability screen patients disorders that have validated screening criteria--specifically tuberculosis (TB) iron-deficiency anemia.Children between 0 11 years were randomized by the CHICA system. In intervention group, parents asked about TB risk, physicians received tailored...
To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions multiple islet autoantibody positivity (mIA).
The immune response after ocular exposure to foreign antigens varies substantially from that of a typical systemic response. Anterior chamber associated deviation (ACAID) has been well documented. the subretinal space not studied in as much detail. Here, we characterized when it encounters AdV-GFP and AAV-GFP (recombinant adenovirus or adeno-associated virus, respectively), each delivering reporter gene encoding green fluorescent protein (GFP). Results indicate possesses an immune-deviant...
Subretinal delivery of recombinant adeno-associated virus (rAAV) results in a systemic humoral response the adult immunocompetent mouse. We characterized this and determined whether it is possible to readminister rAAV subretinal space despite presence antibodies vector. A capsid proteins was induced by either unilateral injection or intradermal administration 1 X 109 infectious units carrying cDNA encoding green fluorescent protein (GFP), rAAV-GFP. Experiments were performed cohorts C57BL/6...
Background: Early television (TV) viewing has been linked with maternal depression and adverse health effects in children. However, it is not known how early TV occurs. This study evaluated the prevalence at which parents report for their children if asked first 2 years of life whether associated symptoms. Methods: Using a cross-sectional design, was 0 to age 4 pediatric clinics Indianapolis, IN, between January 2011 April 2012. Families were screened any parental symptoms (0–15 months)...
Abstract Background Mucopolysaccharidosis VI (MPS VI), due to recessively inherited 4‐sulfatase (4S) deficiency, results in lysosomal storage of dermatan sulfate numerous tissues. Retinal involvement is limited the retinal pigment epithelium (RPE). This study aimed determine whether recombinant adeno‐associated virus (AAV)‐mediated delivery 4S would reverse RPE pathology seen MPS cats. Methods AAV.f4S, containing feline cDNA, was delivered unilaterally eyes affected cats by subretinal or...