A5050472713- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Acne and Rosacea Treatments and Effects
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Retinal Development and Disorders
- Mesenchymal stem cell research
- Skin Protection and Aging
- Hair Growth and Disorders
- Trace Elements in Health
- interferon and immune responses
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Dermatology and Skin Diseases
- Tissue Engineering and Regenerative Medicine
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Phagocytosis and Immune Regulation
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Signaling Pathways in Disease
- Monoclonal and Polyclonal Antibodies Research
Central South University
2020-2025
Xiangya Hospital Central South University
2021-2024
PANoptosis is a newly identified type of regulated cell death that consists pyroptosis, apoptosis, and necroptosis, which simultaneously occur during the pathophysiological process infectious inflammatory diseases. Although our previous literature mining study suggested might in neuronal ischemia/reperfusion injury, little experimental research has been reported on existence PANoptosis. In this study, we used vivo vitro retinal models injury to investigate whether PANoptosis-like...
Abstract Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, body maintains copper homeostasis. deficiency or excess can adversely affect cellular function. Therefore, homeostasis stringently regulated. Recent studies suggest that trigger specific form of cell death, namely, cuproptosis, which triggered by excessive levels intracellular copper. Cuproptosis induces aggregation mitochondrial...
Some scholars have recently developed the concept of PANoptosis in study infectious diseases where pyroptosis, apoptosis and necroptosis act consort a multimeric protein complex, PANoptosome. This allows all components to be regulated simultaneously. provides new way regulation cell death, that different types death may at same time. To test whether exists other than diseases, we chose cerebral ischemia/reperfusion injury as research model, collected articles researching from three major...
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed research hotspots related to brain this work through method bibliometrics from Web Science (WOS) Core database over past two decades. Methods: Documents were retrieved WOS Collection on October 16, 2020. The search terms and strategies used for are as follow: # 1, “pyroptosis”; 2, “pyroptotic”; 3, “inflammasome”; 4, “pyroptosome”; 5 “brain”; 6, “# 1” OR 2” 3” 4”; 7, 5” AND 6”. We...
Background. Sepsis, which could cause a systemic inflammatory response, is life-threatening disease with high morbidity and mortality rate. There evidence that brain injury may be related to severe infection induced by sepsis. The caused sepsis increase the risk of in septic patients, seriously affects patient’s prognosis survival. Although there remains focus on research, clinical measures prevent treat are not yet available, rate still big health burden. Therefore, it necessary investigate...
Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for range of diseases, including ischemic stroke, myocardial infarction, and trauma. Following the restoration blood flow post-tissue ischemia, oxidative stress can lead to various forms cell death, necrosis, apoptosis, autophagy, necroptosis. Recent evidence has highlighted crucial role mitochondrial dysfunction in I/R injury. Nevertheless, there remains much be explored regarding molecular signaling network governing...
Ischemia-reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis newly defined integral form of regulated cell death that combines the key features pyroptosis, apoptosis, and necroptosis. Oligomerization mitochondrial voltage-dependent anion channel 1 an important pathological event regulating ischemia-reperfusion injury. However, its role remains largely unknown. In this study, we demonstrated oligomerization-mediated dysfunction was associated with...
Stroke is a leading risk factor for disability and death. Necroptosis involved in stroke pathogenesis. However, the molecular mechanisms underlying necroptosis remain unclear. The mammalian target of rapamycin complex 1 (mTORC1) modulates gut epithelium. Eukaryotic translation initiation 4E (eIF4E)-binding protein-1 (4EPB1) one main downstream molecules mTORC1. This study addresses role 4EBP1-eIF4E pathway necroptosis. was found to be activated both necroptotic HT-22 mouse middle cerebral...
Methamphetamine (METH) is one of the most widely abused synthetic drugs in world. The users generally present hyperthermia (HT) and psychiatric symptoms. However, mechanisms involved METH/HT-induced neurotoxicity remain elusive. Here, we investigated role heat shock protein 90 alpha (HSP90α) METH/HT (39.5°C)-induced necroptosis rat striatal neurons an
Rosacea is a common and complex chronic inflammatory skin disorder, the pathophysiology etiology of which remain unclear. Recently, significant new insights into rosacea pathogenesis have enriched reshaped our understanding disorder. A systematic analysis based on current studies will facilitate further research pathogenesis.To establish an international core outcome knowledge system develop challenge, trend hot spot set for clinical using bibliometric data mining.A search WoS, PubMed,...