A5044537481- Advanced Measurement and Metrology Techniques
- Geomechanics and Mining Engineering
- Scientific Measurement and Uncertainty Evaluation
- Rock Mechanics and Modeling
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Shoulder Injury and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Laser-Matter Interactions and Applications
- Immune cells in cancer
- Metal Forming Simulation Techniques
- Mesenchymal stem cell research
- Advanced Fiber Laser Technologies
- Structural Engineering and Vibration Analysis
- Epigenetics and DNA Methylation
- Automotive and Human Injury Biomechanics
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- Surface Modification and Superhydrophobicity
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Dam Engineering and Safety
- Spinal Cord Injury Research
Shanghai East Hospital
2019-2025
State Key Laboratory of Cardiovascular Disease
2025
First People's Hospital of Nanning
2024
Sun Yat-sen University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Tongji University
2011-2023
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
2023
Hohhot Minzu College
2023
Hubei University
2023
Beihang University
2022
Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects CCN5 on neointimal formation and its role preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Stent-implanted porcine artery RNA-seq mouse injury-induced femoral neointima single-cell RNA sequencing were performed. Plasma levels measured by enzyme-linked immunosorbent assay. Endothelial cell (EC)- smooth...
Rationale: Endothelial dysfunction results in sustained and chronic vascular inflammation, which is central to atherosclerotic diseases. However, transcriptional regulation of endothelial inflammation has not been well clarified. Objective: This study aims explore Foxp (forkhead box P) transcription factor 1 homeostasis, atherogenesis, its mechanisms. Methods Results: To assess the importance Foxp1 atherosclerosis, expression was analyzed human coronary artery mouse artery, we observed...
The South China Sea (SCS) is the largest marginal sea of western Pacific Ocean, yet little known about archaeal distributions and TEX₈₆-based temperatures in this unique oceanic setting. Here we report findings abundances both core lipids (CL) intact polar (IPL) Archaea from surface water (CL only) core-top sediments different regions SCS. TEX₈₆-derived were also calculated for these samples. had extremely low CL (average 0.05 ± 0.13 ng/liter; n = 75), with higher values present where...
Endothelial dysfunction results in chronic vascular inflammation, which is critical for the development of atherosclerotic diseases. Transcription factor Gata6 has been reported to regulate endothelial cell activation and inflammation vitro. Here, we aimed explore roles mechanisms atherogenesis. (EC) specific deletion was generated ApoeKO hyperlipidemic atherosclerosis mouse model. Atherosclerotic lesion formation, inflammatory signaling, endothelial-macrophage interaction were examined vivo...
The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regulates embryonic cardiomyocyte proliferation and development. However, whether Foxp1 participates in postnatal-injury regeneration remains unclear. This study demonstrates that is downregulated at border zone cardiomyocytes of both neonatal apical resection myocardial infarction. Analysis the Single-cell transcriptome database reveals reduced expression...
Critical limb ischemia (CLI) is a severe blockage in the arteries of lower extremities. However, effective and optimal treatment for CLI remains to be elucidated. Previous therapeutic research mainly focused on proangiogenic growth factors administrations. Recently, miR-21 has been revealed play crucial role angiogenesis. Thus, we hypothesize that over-expression human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) can effectively treat CLI. Herein, UCBMSCs were transduced...
Abstract Current therapeutic drug exploring targeting at myocardial ischemia/reperfusion (I/R) injury is limited due to the lack of humanized cardiac models that resemble damage and inflammatory response. Herein, we develop ventricular organoids from human induced pluripotent stem cells (hiPSCs) simulate I/R by hypoxia/reoxygenation (H/R), which results in increased cardiomyocytes apoptosis, elevated oxidative stress, disrupted morphological structure decreased beat amplitude. RNA‐seq...
The blood-brain barrier (BBB) is a tight boundary formed between endothelial cells and astrocytes, which separates protects brain from most pathogens as well neural toxins in circulation. However, detailed molecular players involved formation of BBB are not completely known. Dentin matrix protein 1 (DMP1)-proteoglycan (PG), known to be mineralization bones dentin, also expressed soft tissues including with unknown functions. In the present study, we reported that DMP1-PG was astrocytes...
The heterogeneity of nasopharyngeal carcinoma (NPC) leads to mixed clinical outcomes.We collected 92 regions interest from 41 biopsies patients with untreated NPC and obtained their transcripts using GeoMx Digital Spatial Profiling (DSP) technology.Spatial was determined by measuring the expression marker genes in tumor cell-enriched (PanCK-expressing), immune (CD45-expressing), normal epithelial (Endo) regions.We screened 16 prognostic markers 4 regions.The levels CD8 + T follicular helper...
Aims . To investigate whether bone marrow derived mesenchymal stromal cells (BMSC) have ameliorated ischemia/reperfusion injury-induced acute kidney injury (IRI-AKI) via tumor necrosis factor-inducible gene 6 protein (TSG-6) and how TSG-6 exerted this effect. Methods We used lentiviral vectors of short hairpin RNA (shRNA) targeting to silence in BMSC. And TSG-6-silenced BMSC were administrated into IRI-AKI rats. Then we analyzed serum creatinine (Scr) renal histology rats treated with after...
Background The endothelium is essential for maintaining vascular physiological homeostasis and the endothelial injury leads to neointimal hyperplasia because of excessive proliferation smooth muscle cells. Endothelial Foxp1 (forkhead box P1) has been shown control cell (EC) migration in vitro. However, whether EC-Foxp1 participates formation vivo not clear. Our study aimed investigate roles mechanisms hyperplasia. Methods Results wire femoral artery model was performed EC-specific...
Abstract Real-world data on effectiveness and safety of a single non-vitamin K antagonist oral anticoagulant in the Chinese population with atrial fibrillation (AF) are limited. This study reports characteristics patients treated edoxaban factors associated dosing patterns from routine care China. ETNA-AF-China (NCT04747496) is multicentre, prospective, observational enrolling edoxaban-treated four economic regions targeted 2-year follow-up. Of 4930 AF (mean age: 70.2 ± 9.5 years; male,...
Quantifying rock physical properties is essential for the mining and petroleum industry. Microtomography provides a new way to quantify relationship between microstructure mechanical transport of rock. Studies reporting use microtomographic images derive permeability elastic moduli rocks are common; only rare studies were devoted yield failure parameters using this technique. In study, we simulate macroscale plastic synthetic sandstone sample made calcite-cemented quartz grains microscale...
Stem cell-based repair strategies for spinal cord injury (SCI) are a highly studied area of research. Multiple gene-modified stem cells have been transplanted into SCI models, in the hope generating more neurons to damaged nervous system. However, results not always successful, as grafted may be unable survive injured cord. E-cadherin, transmembrane adhesion protein, has identified an epithelial-to-mesenchymal transition marker and is vital morphological structure maintenance functional...
Abstract Pitch uncertainty and line edge roughness are among the critical quality attributes of a pitch standard normally analyses these two parameters separate. The analysis self-traceable Cr atom lithography nano-gratings shows positive relevance sensitivity between LER evaluated deviation pitch. Therefore, can be used as an aided pre-evaluation parameter for calculation method, such gravity center method or zero-crossing points method. optimization nano-grating evaluation helps to obtain...
Uncertainties in parameters can affect racing car performance. In this study, a nonlinear interval suspension damping optimization method is proposed to improve the road holding of car. To evaluate dynamic responses cars under random input and bump with uncertain parameters, quarter model two-stage asymmetric damper established. Then, quadratic approximation second derivative terms developed by second-order Taylor series expansion dimension reduction calculate response vehicle. Interval...
Methyl-CpG-binding protein 2 (MeCP2) is a well-known transcription repressor, and mutations in MECP2 cause serious neurological disorders. Many studies have suggested that MeCP2 involved neural maturation only, not reported its role stem cell differentiation. In the present study, we investigated this possible of cells. We used two different differentiation methods to explore how influences When transfected MeCP2-overexpressing lentivirus into cells, astrocytic was impaired. This impaired...