A5083357106- Sphingolipid Metabolism and Signaling
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lymphatic System and Diseases
- Inflammasome and immune disorders
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
- Genetics and Neurodevelopmental Disorders
- Angiogenesis and VEGF in Cancer
- Liver physiology and pathology
- Biomarkers in Disease Mechanisms
- Healthcare Systems and Public Health
- Signaling Pathways in Disease
Shanghai East Hospital
2022-2025
State Key Laboratory of Cardiovascular Disease
2024-2025
Tongji University
2022-2023
Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects CCN5 on neointimal formation and its role preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Stent-implanted porcine artery RNA-seq mouse injury-induced femoral neointima single-cell RNA sequencing were performed. Plasma levels measured by enzyme-linked immunosorbent assay. Endothelial cell (EC)- smooth...
Aims: It is important to understand the mechanism that regulates post-ischemic angiogenesis and explore a new therapeutic target for an effective improvement of revascularization in peripheral artery disease (PAD) patients.Post-ischemic highly orchestrated process, which involves vascular endothelial cells (ECs) proliferation, migration assembly into capillaries.We found significant reduction S1pr2 (sphingosine 1-phosphate receptor 2) after hindlimb ischemia (HLI).We thus hypothesized...
Sphingosine 1-phosphate (S1P), a bioactive lipid molecule, exerts multifaceted effects on cardiovascular functions via S1P receptors, but its cardiac I/R injury are not fully understood. Plasma lipidomics analysis by mass spectrometry revealed that sphingosine lipids, including were significantly down-regulated following in mice. The reduced levels also observed the plasma of coronary heart disease (CHD) patients after percutaneous intervention (PCI) compared with those without PCI. We found...
Abstract The hepatic vascular niche plays an important role in the pathological process of liver fibrosis. Liver sinusoidal endothelial cells (LSECs) predominantly compose niches. Endothelial cell (EC)‐expressing sphingosine 1‐phosphate receptor 2 (S1pr2) essential regulation functions. Nevertheless, it remains unknown whether LSEC‐S1pr2 might modulate In this study, fibrosis was induced by hepatotoxin carbon tetrachloride (CCl 4 ). expression S1pr2 is significantly downregulated after CCl...
Lymphatic endothelial cell homeostasis plays important roles in normal physiological cardiac functions, and its dysfunction significantly influences pathological remodeling after myocardial infarction (MI). Our results revealed that sphingosine 1-phosphate receptor 1 (S1pr1) expression lymphatic cells (LECs) was sharply changed MI. It has been shown S1pr1 tightly controlled LEC functions homeostasis. We thus hypothesized might be involved post-MI remodeling. generated LEC-conditional...
Objective: The association of lipoprotein(a) [Lp(a)] with atherosclerotic cardiovascular disease (ASCVD) risk can be modified by chronic systemic inflammation. neutrophil-to-lymphocyte ratio (NLR) is a reliable and easily available marker immune response to various infectious non-infectious stimuli. purpose this study was assess the combined effects Lp(a) NLR in predicting ASCVD coronary artery plaque traits. Methods: This included 1618 patients who had computed tomography angiography (CTA)...
Aims: Lower vertebrates and some neonatal mammals are known to possess the ability regenerate cardiomyocyte fully recover after heart injuries within a limited period. Understanding molecular mechanisms of regeneration exploring new ways enhance cardiac hold significant promise for therapeutic intervention failure. Sphingosine 1-phospahte receptor 1 (S1PR1) is highly expressed in cardiomyocytes plays crucial role development pathological remodeling. However, effect cardiomyocyte-expressing...