A5084600019- Oral microbiology and periodontitis research
- Extracellular vesicles in disease
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Immune cells in cancer
- Oral Health Pathology and Treatment
- Autophagy in Disease and Therapy
- Periodontal Regeneration and Treatments
- Diabetes and associated disorders
- Tissue Engineering and Regenerative Medicine
- Retinoids in leukemia and cellular processes
- Immunotherapy and Immune Responses
- Silk-based biomaterials and applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telomeres, Telomerase, and Senescence
- Neonatal Health and Biochemistry
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- Immune responses and vaccinations
Stomatology Hospital
2019-2024
Sun Yat-sen University
2019-2024
Hospital of Stomatology, Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2021
Periodontitis is caused by host immune-inflammatory response to bacterial insult. A high proportion of pro-inflammatory macrophages anti-inflammatory leads the pathogenesis periodontitis. As stem cell-derived exosomes can modulate macrophage phenotype, dental pulp (DPSC-Exo) effectively treat In this study, we demonstrated that DPSC-Exo-incorporated chitosan hydrogel (DPSC-Exo/CS) accelerate healing alveolar bone and periodontal epithelium in mice with Gene Ontology (GO) term enrichment...
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, hampered clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, potential function of MSC-exos produced (3D-exos) periodontitis remains elusive. This study showed that compared generated via (2D-exos), 3D-exos enhanced...
Abstract Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related DP. Moreover, inhibition oral administration bindarit reduced alveolar bone loss increased epithelial thickness...
Abstract The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk fragility fractures. However, the specific mechanisms HFD-induced are not fully understood. Our study shows that exposure HFD induces premature senescence in bone marrow mesenchymal stem cells (BMSCs), diminishing their proliferation osteogenic capability, thereby contributes osteoporosis. Transcriptomic chromatin accessibility analyses revealed decreased vitamin D receptor (VDR)-binding...
The severe pain caused by oral ulcers seriously affects food intake and speech, bringing great inconvenience in daily life. Drug-loaded patches are mostly used to treat mucosal diseases such as lichen planus, but their effects limited because of the influences saliva muscle movement. To enhance adhesion drug-loaded cavity, we designed antimicrobial peptides (AMPs)-modified polycaprolactone (PCL)-collagen nanosheets (APCNs). internal layer is a bioactive antibacterial collagen modified with...
Hyperglycemic micro-environment induced by diabetes could regulate the response of periodontal tissues to pathogenic microorganisms in which disruption autophagy lysosomal pathway (ALP) may participate. This study aimed explore mechanisms underlying how high glucose (HG) regulates ALP gingival epithelial cells (GECs).Human healthy group (C), periodontitis (P), (DM), and + (DP) were collected applied observe fusion lysosome. Diabetic mouse model with was established RNA-seq investigate...
To explore the mechanism underlying autophagy disruption in gingival epithelial cells (GECs) diabetic individuals. Bone marrow-derived macrophages (BMDMs) and GECs were extracted from C57/bl db/db mice, exosomes (Exo) isolated BMDMs. qRT‒PCR Western blotting performed to analyse gene expression. The AnimalTFDB database was used identify relevant transcription factors, miRNA sequencing utilised miRNAs with aid of TargetScan/miRDB/miRWalk databases. A dual-luciferase assay conducted verify...
Mucosal immunity plays a critical role in the pathogenesis of inflammatory immune diseases. This study leverages single-cell RNA sequencing, spatial transcriptomics, and proteomics to compare cellular mechanisms involved periodontitis between humans mice, aiming develop precise strategies protect gingival mucosal barrier. We identified key conserved divergent features landscapes transcriptional profiles across two species, underscoring complexity responses dynamics periodontitis....