A5100406848- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Genomics and Chromatin Dynamics
- Mass Spectrometry Techniques and Applications
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant biochemistry and biosynthesis
- Catalytic Processes in Materials Science
- T-cell and B-cell Immunology
- Biological Activity of Diterpenoids and Biflavonoids
- Immune Cell Function and Interaction
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Sirtuins and Resveratrol in Medicine
- Membrane Separation and Gas Transport
- Electrospun Nanofibers in Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Advanced Proteomics Techniques and Applications
- Catalysis and Hydrodesulfurization Studies
- Attention Deficit Hyperactivity Disorder
- Fluorine in Organic Chemistry
- Autophagy in Disease and Therapy
- Covalent Organic Framework Applications
Dalian Institute of Chemical Physics
2008-2025
Chinese Academy of Sciences
2008-2025
University of Chinese Academy of Sciences
2008-2025
Hainan University
2025
University of Jinan
2024
Cornell University
2019-2023
Liaoning Ocean and Fisheries Research Institute
2023
Beijing Institute of Genomics
2019-2021
Memorial Sloan Kettering Cancer Center
2019
Wuhan University
2018
Five examples of selectively fluorinated unsymmetrical diiminoacenaphthylenes, 1-[2,6-{(4-FC6H4)2CH}2-4-FC6H4N]-2-(ArN) C2C10H6 (Ar = 2,6-Me2C6H3L1, 2,6-Et2C6H3L2, 2,6-iPr2C6H3L3, 2,4,6-Me3C6H2L4, 2,6-Et2-4-MeC6H2L5), have been synthesized and used to prepare their corresponding nickel(ii) halide complexes, LNiBr2 (Ni1-Ni5) LNiCl2 (Ni6-Ni10). Both 1H 19F NMR spectroscopy techniques employed characterize paramagnetic Ni1-Ni10; an inequivalent fluorine environment is a feature the tetrahedral...
Multicellular organisms require precise gene regulation during ontogeny, and epigenetic modifications, such as DNA methylation histone modification, facilitate this regulation. The conservative reprogramming patterns of in vertebrates have been well described. However, knowledge how modifications are passed on from gametes to early embryos is limited, whether modification conserved not clear. We profiled H3K4me3/H3K27me3 zebrafish found that the promoter regions largely set either...
Foxp3+ regulatory T (T reg) cells are pivotal regulators of immune tolerance, with cell receptor (TCR)–driven activated reg (aT playing a central role; yet how TCR signaling propagates to control aT responses remains poorly understood. Here we show that induces expression amino acid transporters, and renders acid–induced activation mTORC1 in cells. cell–specific ablation the Rag family small GTPases RagA RagB impairs signaling, causing defective anabolism, reduced proliferation, rampant...
Abstract DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been shown to be involved the regulation of gene expression embryo development. However, remains unclear how regulates sexual development, especially species without sex chromosomes. To determine this, we utilized zebrafish investigate reprogramming during juvenile germ cell development adult female-to-male transition. We reveal that primordial cells (PGCs) undergo significant methylome PGCs reset an...
Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is widely used in untargeted metabolomics, but large-scale and high-accuracy metabolite annotation remains a challenge due to the complex nature of biological samples. Recently introduced electron impact excitation ions from organics (EIEIO) fragmentation can generate information-rich fragment ions. However, effective utilization EIEIO tandem (MS/MS) hindered by lack reference spectral databases. Molecular networking (MN)...
Adsorption is a widely used technology for controlling volatile organic compound (VOCs) emissions. The significant reduction of the VOCs adsorption capacity adsorbents under high humidity currently one key factors restricting practicality technology. In this study, we synthesized representative PAF, namely, PAF-79, with objective investigating its effectiveness in removing VOCs, especially high-humidity conditions. dynamic experiments, due to abundant micropores, PAF-79 exhibited an...
The adsorption of volatile organic compounds (VOCs) on phenolic-based carbon fibers is a current research hotspot. However, the inner association between preoxidation, carbonization, and performance insufficient. This work studied electrospinning, carbonization conditions thermosetting phenolic resin relevant effects VOC derived activated fibers. static dynamic performances benzene over four types were tested, oxygenated VOCs (OVOCs) introduced for binary competitive tests. results indicate...
Definitive structural elucidation of lipids is pivotal for unraveling the functions in biological systems. Despite advancements mass spectrometry (MS) lipid analysis, challenges annotation scope and efficiency remain, especially resolving isomers. Herein, we introduce an optimized method using liquid chromatography coupled with electron impact excitation ions from organic tandem (LC-EIEIO-MS/MS) comprehensive analysis lipids. This approach integrates a six-step analytical protocol precise...
Important pathway identification is essential for unraveling biological mechanisms in functional metabolomics. However, current enrichment often biased toward well‐characterized pathways due to low annotation rates untargeted metabolomics and incomplete coverage. It leads potential misinterpretation of data. Herein, Siamese transformer reaction pair (STRP) prediction, an approach important exploration metabolomics, introduced. STRP leverages a weight‐sharing network multihead attention...
Breast invasive micropapillary carcinoma (IMPC) is a rare subtype of breast cancer with high potential lymph node metastasis, aggressive clinical behavior, and poor disease-free or overall survival. Expression leucine zipper putative tumor suppressor 1 (LZTS1) was frequently lost reduced in tissues. This study investigated the expression LZTS1 protein IMPC tissues using immunohistochemistry. In addition, somatic mutations promoter methylation were assessed to determine an association...
Glycosides are a large family of secondary metabolites in plants, which play critical role plant growth and development. Due to the complexity diversity structures limited availability authentic standards, comprehensive annotation glycosides remains great challenge. In this study, using maize as an example, deep method was proposed based on untargeted liquid chromatography–high-resolution tandem mass spectrometry metabolomics analysis. First, knowledge-based silico aglycone...
Untargeted metabolomics using liquid chromatography–electrospray ionization–high-resolution tandem mass spectrometry (UPLC–ESI–MS/MS) provides comprehensive insights into the dynamic changes of metabolites in biological systems. However, numerous unidentified metabolic features limit its utilization. In this study, a novel approach, Chemical Classification-driven Molecular Network (CCMN), was proposed to unveil key pathways by leveraging hidden information within features. The method...
Plant diterpene glycosides are essential for diverse physiological processes. Comprehensive structural characterization proved to be a challenge due variations in glycosylation patterns, aglycone structures, and the absence of comprehensive reference databases. In this study, method fine-scale was proposed based on energy-resolved (ER) untargeted LC-MS/MS metabolomics analysis using steviol as demonstration. Energy-dependent fragmentation patterns were unveiled by series model compounds....
Large-scale metabolite annotation is a bottleneck in untargeted metabolomics. Here, we present structure-guided molecular network strategy (SGMNS) for deep of ultra-performance liquid chromatography-high resolution mass spectrometry (MS) metabolomics data. Different from the current network-based method, SGMNS based on global connectivity (GCMN), which was constructed by fingerprint similarity chemical structures metabolome databases. Neighbor metabolites with similar GCMN are expected to...
Direct-infusion Fourier transform ion cyclotron resonance mass spectrometry (DI-FTICR MS) shows great promise for metabolomic analysis due to ultrahigh accuracy and resolution. However, most of the DI-FTICR MS approaches focused on high-throughput metabolomics at expense sensitivity resolution potential metabolome characterization has not been fully explored. Here, we proposed a novel deep approach serum using segment-optimized spectral-stitching method integrated with high-confidence...