A5086190885- Catalytic C–H Functionalization Methods
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- Sulfur-Based Synthesis Techniques
- Fungal Plant Pathogen Control
- Computational Drug Discovery Methods
- Acute Myeloid Leukemia Research
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Metabolism, Diabetes, and Cancer
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Reactions
- Geomechanics and Mining Engineering
- Acute Lymphoblastic Leukemia research
- Bioactive natural compounds
- Inflammatory mediators and NSAID effects
- Cholinesterase and Neurodegenerative Diseases
Guiyang Medical University
2016-2025
Institute of Medicinal Plant Development
2023
Guiyang University
2016
Henan Polytechnic University
2015
Guangxi Normal University
2015
China Pharmaceutical University
2015
Huaqiao University
2014
Henan University Huaihe Hospital and Huaihe Clinical Institute
2013
Nanyang Medical College
2008-2009
The transition-metal-catalyzed ring-opening functionalization of aziridines presents a promising approach for synthesizing structurally complex amines. However, the rearranged poses significant challenges. Herein, we report first alkenylation with aryl alkenes via Ni-Brønsted acid co-catalysis, leading to rapid synthesis diverse array allylamines yields reaching up 91%. Mechanistic studies suggest that reaction occurs through rearrangement aziridine generate an imine intermediate. This...
A chiral carbene-catalyzed dynamic kinetic resolution for the facile synthesis of enantioenriched dihydro-1,4-benzoxazine-2-carboxylates is disclosed. The reaction conditions are mild, and a diversity substituents well-tolerated in this transformation. In addition, our methodology also provides an efficient strategy building chromane-2-carboxylate 2,3-dihydro-1,4-benzodioxane-2-carboxylate. optically pure products generated from protocol can be easily derived as key intermediates drugs...
Herein, we reported a DBU-catalyzed cascade and sequential [1 + 2 3] annulation of malononitrile with α,β-unsaturated ketones to access polyfunctionalized cyclohexanes high yield excellent diastereoselectivity (>93% yield, >19:1 dr). Intriguingly, this appears be the new strategy for using either as 2C or 3C synthon react dinucleophile 1C construct six-membered carbocycles in one-pot manner. In addition, these synthesized compounds suppressed growth phytopathogenic fungi vitro. Among them,...
Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, series 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened their activities against PI3Kα panel PI3Kα-addicted cells. Among them, compound 35 was identified as inhibitor with nanomolar potency well acceptable antiproliferative activity. Flow cytometry analysis confirmed induced cell cycle arrest apoptosis in T47D addition, it also showed vitro ADME properties. The...
Four series of novel 1,3,4-oxadiazole/1,2,4-triazole hybrids phthalide derivatives were designed and synthesized to search for potential antifungal agents. Preliminary activity assay results showed that compounds 4 a, b, m, 5 f, h, 7 h exhibited moderate excellent inhibitory against some phytopathogenic fungi. Among them, compound b displayed the most outstanding effects V. mali S. sclerotiorum, with EC
The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with inherent limitations antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual screening followed by experimental validation a proven approach discover active compounds. In this study, we employed multistage virtual methods screen multiple compound databases predict new ligands. 35 compounds were proposed combined analysis fitness...
Background and Purpose Glucagon‐like peptide‐1 (GLP‐1) is an important target for diabetes therapy based on its key role in maintaining glucose lipid homeostasis. This study was designed to investigate antidiabetic hepatoprotective effects of a novel oleanolic acid derivative DKS26 diabetic mice elucidate underlying GLP‐1 related mechanisms vitro vivo . Experimental Approach The therapeutic were investigated streptozotocin (STZ)‐induced db/db mouse models. Levels plasma glucose, glycosylated...
An efficient and ligand-free palladium/copper-catalyzed Heck-type coupling reaction of <italic>N</italic>′-acyl arylhydrazines with olefins for the practical synthesis arylalkenes.
A novel ligand‐free palladium‐catalyzed C‐2 arylation of benzofurans has been developed using N′ ‐acyl arylhydrazines as the coupling partners and TEMPO an oxidant. This protocol features a wide functional‐group tolerance highly regioselective products with good to excellent yields.
Context Hydrogen peroxide (H2O2)-induced damage in the lens epithelium leads to cell death and cataract. Semiaquilegia adoxoides (DC.) Makino (Ranunculaceae), a folk medicine of Hmong (an ethnic group China), has been traditionally used treat cataract; however, underlying molecular mechanism is yet be uncovered. Objective This study aimed investigate whether n-butanol extract S. (nSA) effective against H2O2-induced oxidative stress human epithelial (HLE) cells. Materials methods Human (SRA...
A redox-neutral coupling of allyl alcohols with trifluoromethyl ketones has been developed via Ni–Ti bimetallic catalysis. This innovative method allows for the efficient synthesis various β-tertiary alcohol-substituted yields up to 98%. The reaction is scalable and compatible a wide range substrates, including complex bioactive molecules. Mechanistic studies suggest that rate-determining step involving β-H elimination presence Ti-based Lewis acid, as well hydroxyl group on crucial driving...
Abstract A transition metal‐free synthesis of 2‐arylquinoxaline is achieved by using arylhydrazine salt as an aryl radical arylation reagent and air oxidant in the presence K 2 CO 3 . This protocol features metal‐free, no additives, mild reaction conditions, environment friendly, can be used to construct biologically active molecules containing 2‐phenylquinoxaline structure.