A5102947246- Inflammatory Bowel Disease
- Gut microbiota and health
- Neural Networks and Reservoir Computing
- Nonlinear Dynamics and Pattern Formation
- Curcumin's Biomedical Applications
- Tea Polyphenols and Effects
- Neural dynamics and brain function
- Adipokines, Inflammation, and Metabolic Diseases
- PI3K/AKT/mTOR signaling in cancer
- Chaos control and synchronization
- Advanced Memory and Neural Computing
- Model Reduction and Neural Networks
- Power System Optimization and Stability
- RNA and protein synthesis mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Photodynamic Therapy Research Studies
- Gastrointestinal motility and disorders
- RNA modifications and cancer
- Neural Networks and Applications
- Neural Networks Stability and Synchronization
- Biochemical Analysis and Sensing Techniques
- Nanoplatforms for cancer theranostics
- Metabolism, Diabetes, and Cancer
- Protein Kinase Regulation and GTPase Signaling
- Fermentation and Sensory Analysis
Shaanxi Normal University
2021-2025
Guiyang Medical University
2020-2021
Chongqing Medical University
2016-2020
New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) photodynamic inactivation (PDI)-active AIEgens (luminogens aggregation-induced emission property) was presented to generate type AIE–PAP bioconjugate superior capability for both imaging synergistic killing certain species bacteria. The targeting ability...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease related to intestinal dysbiosis. Luteolin has been reported reduce inflammation. However, it remains unclear whether luteolin ameliorates UC and regulates gut microbiota. In this study, we investigated the effects of on colonic structure inflammation dextran sulfate sodium (DSS)-induced rats using hematoxylin-eosin staining, immunohistochemistry enzyme-linked immunosorbent assay evaluated microbiota 16S rDNA sequencing. We found...
Gut barrier dysfunction is triggered by gut microbiota dysbiosis that closely associated with ulcerative colitis. Recently, more attention has been devoted to the ability of non-digestively colon-targeted plant polysaccharides regulate function and composition intestinal microbiota. Here, we first studied prophylactic capacity turmeric (TPS) ameliorate dextran sulfate sodium (DSS)-induced imbalance. The results revealed TPS administration could greatly improve pathological phenotype,...
This study was designed to first verify the protective capacity of turmeric powder (TP) as a traditional cooking spice against dextran sulfate sodium (DSS)-induced intestinal inflammation and intestine microbiota imbalance. The DSS-induced mice were fed standard rodent chow supplemented with or without TP (8%) for 37 days. results indicated that pathological phenotype, gut barrier disruption, colon significantly improved through supplementation TP. In addition, 16S rRNA-based targeted...
This study was designed to elucidate the colon microbiota-targeted release of nonextractable bound polyphenols (NEPs) derived from Fu brick tea and further identify possible anti-inflammatory mechanism in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. 1.5% DSS drinking water-induced C57BL/6J mice were fed rodent chow supplemented with or without 8% NEPs dietary fibers (DFs) for 37 days. The p-hydroxybenzoic acid quercetin liberated up 590.5 ± 70.6 470.5 51.6 mg/g by vitro...
Solid evidence has emerged supporting the role of nonextractable polyphenols (NEPs) and dietary fibers (DFs) as gut microbiota modulators. This study aims to elucidate microbiota-dependent release turmeric NEPs examine possible anti-inflammatory mechanism in dextran sulfate sodium-induced ulcerative colitis (UC) model. 1.5% DSS drinking water-induced C57BL/6J mice were fed a standard rodent chow supplemented with or without 8% extractable (EPs), NEPs, DFs for 37 days. The bound curcumin,...
Power systems dominated by renewable energy encounter frequently large, random disturbances, and a critical challenge faced in power-system management is how to anticipate accurately whether the perturbed will return functional state after transient or collapse. Whereas model-based studies show that key addressing lies attracting basins of dysfunctional states phase space, finding for realistic power remains challenge, as accurate models describing system dynamics are generally unavailable....
Model-free reconstruction of bifurcation diagrams Chua's circuits using the technique parameter-aware reservoir computing is investigated. We demonstrate that (1) computer can be utilized as a noise filter to restore system dynamics from noisy signals; (2) for single Chua circuit, machine trained by time series measured at several sampling states capable reconstructing whole diagram circuit with high precision; and (3) two coupled chaotic mismatched parameters, coupling strengths able...
This study first evaluated the protective effects of Fu brick tea water extracts (FTE) on alcoholic liver injury and its underlying mechanism in C57BL/6J mice. Oral administration FTE by oral gavage (400 mg per kg bw) for 12 weeks significantly alleviated lipid metabolism disorder, reduced activities serum ALT AST, decreased expression CYP2E1 gene, enhanced antioxidant capacities livers alcohol-fed mice (p < 0.05). also relieved alcohol-induced gut microbiota dysbiosis promoting...
This study was designed to verify the anti-obesity effect of dietary turmeric powder (TP) as a traditional cooking spice and its underlying mechanism. The HFD-fed C57BL/6J mice were supplemented with or without TP (8%) for 12 weeks. results indicated that glucolipid metabolism disorder high-fat diet (HFD)-fed significantly ameliorated through supplementation TP. consumption also induced beige-fat development brown adipose tissue (BAT)-derived nonshivering thermogenesis in obese mice. 16S...
Fructo-oligosaccharide (FOS) is a typical prebiotic with intestinal health-promoting effects. Here, we explored the anticolitis activity of FOS and clarified underlying mechanisms. Dextran sulfate sodium (DSS)-induced mice were gavaged (400 mg/kg) for 37 days, administration alleviated DSS-induced colitis symptoms. Besides, improved gut microbiota dysbiosis modulated microbiota-controlled tryptophan metabolic pathways. Targeted metabolomic results showed that significantly increased colonic...
Whereas the power of reservoir computing (RC) in inferring chaotic systems has been well established literature, studies are mostly restricted to monofunctional machines where training and testing data acquired from same attractor. Here, using strategies attractor labeling trajectory separation, we propose a scheme RC capable learning multiple attractors generated by entirely different dynamics, namely multifunctional RC. Specifically, demonstrate that incorporating label channel into...
Whereas the importance of transient dynamics to functionality and management complex systems has been increasingly recognized, most studies are based on models. Yet in realistic situations mathematical models often unknown what is available only measured time series. Meanwhile, many real-world dynamically stable, sense that return their equilibria a short after perturbations. This increases further difficulty analysis, as information system lost once settled onto equilibrium states. The...
Whereas the power of reservoir computing (RC) in inferring chaotic systems has been well established literature, studies are mostly restricted to mono-functional machines where training and testing data acquired from same attractor. Here, using strategies attractor labeling trajectory separation, we propose a new scheme RC capable learning multiple attractors generated by entirely different dynamics, namely multi-functional RC. Specifically, demonstrate that incorporating label channel into...
Apobec-1 complementation factor (A1CF) is a heterogeneous nuclear ribonuceloprotein (hnRNP) and mediates apolipoprotein-B mRNA editing. A1CF can promote the regeneration of liver by post-transcriptionally stabilizing Interleukin-6 (IL-6) mRNA. It also contains two transcriptional variants-A1CF64 A1CF65, distinguished appearance 24-nucleotide motif which contributes to corresponding eight-amino acid EIYMNVPV. For first time, we demonstrated that EIYMNVPV was essential for nucleus...
A model-free approach is proposed for anticipating the occurrence of measure synchronization in coupled Hamiltonian systems. Specifically, by technique parameter-aware reservoir computing machine learning, we demonstrate that trained time series systems at a handful coupling parameters able to predict accurately not only critical synchronization, but also variation system order around transition point. The capability exemplified two oscillators and three globally where partial arises....
Cluster synchronization in synthetic networks of coupled chaotic oscillators is investigated. It found that despite the asymmetric nature network structure, a subset can be synchronized as cluster while other remain desynchronized. Interestingly, with increase coupling strength, expanding gradually by recruiting desynchronized one one. This new phenomenon, which named “scalable cluster,” explored theoretically method eigenvector-based analysis, and it revealed scalability attributed to...
This study was for the first time to reveal anti-obesity effect of summer-autumn tea aqueous extract (SATE) and its underlying mechanism. High-fat diet (HFD)-fed C57BL/6J mice were treated with...