A5016096487- Magnetic and Electromagnetic Effects
- Hydrogen Storage and Materials
- Catalytic Processes in Materials Science
- Advanced Chemical Physics Studies
- Drug Transport and Resistance Mechanisms
- Freezing and Crystallization Processes
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
Beijing University of Agriculture
2025
Hainan University
2025
University of Science and Technology Beijing
2023-2024
Zhengzhou University
2023-2024
Fo Guang University
1999
A highly selective ferroptosis inducer with drug-like properties can significantly advance the research on inducing for anticancer treatment. We previously reported a active GPX4 inhibitor 26a, but its activity and stability need further improvement. In this work, novel (R)-9i more potent cytotoxicity (IC50 = 0.0003 μM against HT1080) selectivity (selectivity index 24933) was gained via electrophilic warhead screening structure-based optimization. The cellular thermal shift assay (CETSA)...
Certain tree species can reach ages of centuries, whereas lifespan like apple are markedly shorter. The latter is caused by negative plant-soil feedback that results in microbiome changes. We hypothesized with a long will be able to avoid such and their root-associated microbiomes similar trees different ages. To test this, we used Chinese chestnut (Castanea mollissima) trees, ranging from 8 830 years old Ming orchard at the Great Wall. Their were analysed using meta-amplicon sequencing...