A5101661980- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Electronic Packaging and Soldering Technologies
- Circular RNAs in diseases
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- 3D IC and TSV technologies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Orthopaedic implants and arthroplasty
- DNA and Nucleic Acid Chemistry
- Metallurgy and Material Forming
- Soil Mechanics and Vehicle Dynamics
- Computational Drug Discovery Methods
- Dam Engineering and Safety
- Geomechanics and Mining Engineering
- Soil, Finite Element Methods
- Protein Structure and Dynamics
- Vehicle Dynamics and Control Systems
- Geotechnical Engineering and Analysis
- Mechanical stress and fatigue analysis
- Metal Forming Simulation Techniques
- Advanced Wireless Communication Technologies
- Landslides and related hazards
- Engineering Structural Analysis Methods
Shenzhen University
2019-2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Jiangsu University of Science and Technology
2024
Third Xiangya Hospital
2015-2024
Central South University
2015-2024
China Telecom
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
China Telecom (China)
2024
Fudan University
2024
Senescent cells exert a significant influence over their surrounding cellular environment. chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present joints affected by osteoarthritis. The of SnChos on exogenously transplanted stem has yet reported. In this study, we evaluated the interactions between and bone marrow mesenchymal (BMSCs) when co-cultured as well intra-articular senescent microenvironment (IASM). effect IASM regeneration was also assessed. It that...
Aims: This study aimed at exploring the mechanism of ferroptosis (an iron-dependent form nonapoptotic cell death) resistance in senescent chondrocytes (SenChos). Results: In this study, by utilizing metabolomics and single-cell RNA sequencing, we found that hyperactivation metabolism was one most prominent metabolic features SenChos. Interestingly, however, SenChos were able to survive state resistant ferroptosis-induced death. Next, elucidated survival could be primarily attributed...
Bladder cancer, a common malignancy of the urinary tract, presents complex therapeutic challenges, thereby necessitating exploration innovative treatment strategies. This study introduces novel, self-propelled nanomedicine delivery system that forms nanoparticles within bladder lumen by co-infusing dopamine hydrochloride, Mn2+, cGAMP, and urease into to initiate in situ polymerization. The resulting Mn-cGAMP@PDA-urease (DMCU) possess urease-modified surface, which acts as an engine generate...
Abstract Long non-coding RNA (lncRNA) DANCR has been reported to participate in key processes such as stem cell differentiation and tumorigenesis. In a high throughput screening for lncRNAs involved Doxorubicin-induced apoptosis, we found was suppressed by Doxorubicin it acted an important repressor of apoptosis colorectal cancer. Further studies demonstrated that promoted the oncogenic lncRNA MALAT1 expression via enhancing stability suppress apoptosis. could efficiently mediate suppressive...
A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA into MBG precursor solution. Different structures and properties were acquired different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, hydrophilicity of the PLGA-MBG characterized. Results scanning electron microscopy indicated that made rougher increase content....
Previous genome-wide transcriptome profiling found circ_ZNF124 was highly expressed in lung adenocarcinoma, however, the role of non-small cell cancer (NSCLC) is still unknown. The purpose this study to investigate and molecular mechanism NSCLC development.The expression circ_ZNF124, miR-337-3p JAK2 (Janus Kinase 2) lines normal epithelial cells were detected by qRT-PCR (quantitative real-time PCR). siRNA used knockdown cells. effects determined growth, migration, cycle analysis colony...
The special morphology of CaTiO<sub>3</sub> coatings synthesized by a facile hydrothermal method improved titanium's <italic>in vitro</italic> and vivo</italic> biocompatibility.
Wound dressings with drug delivery system have drawn increasing attention in skin damage recombination. Herein, a novel composite biological dressing was prepared and based on poly(vinyl alcohol) (PVA) combined carbon nanotubes (CNTs) epidermal growth factor (EGF) by electrospinning gauze. The properties of the CNTs/PVA/EGF were systemically investigated general observation, scanning electron microscopy (SEM). In vitro, cytotoxicity this using methyl thiazolyl tetrazolium (MTT) assay L929...
MicroRNAs (miRs) are a class of small non‑coding RNAs and have key roles in various cancer types. Recently, miR‑503 has been reported to act as tumor suppressor osteosarcoma. However, the detailed mechanism regulatory role osteosarcoma cell proliferation invasion largely remained elusive. The present study found that was significantly downregulated tissues compared matched adjacent non‑tumorous tissues. In addition, expression T3‑T4 stage lower when with T1‑T2 samples. also lines (Saos‑2,...
Aim: To investigate the effects of SKA3 on cell proliferation and metastasis in non-small-cell lung cancer (NSCLC) its underlying mechanism. Methods: Immunohistochemistry was employed to analyze expression NSCLC. CCK-8 assay, EdU Transwell assay flow cytometry analysis were assess proliferation, metastatic potential apoptosis vitro, respectively. A model used evaluate NSCLC cells vivo. luciferase reporter gene conducted verify targeting relationship. Results: exhibited high tissues cells....
In this paper, two three dimensional finite element models were developed to numerically compute the stress, total strain, plastic strain and cumulative of solder joints in a microBGA chip scale package (CSP) under temperature cycling. These stress values, along with results fatigue tests, then used predict joint lifetime through either strain-based approaches such as Coffin-Manson modified equations or stress-based approach (S-N curve). Particular attention was given complex profile thermal...
Abstract The soil-water characteristic curve is an important in the study of unsaturated soil mechanics. It plays role improving theoretical analysis and numerical calculation geotechnical engineering to find out effect initial dry density on SWCC. Based filter paper test, four curves Hefei remolded expansive samples under different densities were determined. influence SWCC was systematically analyzed. results show that: (1) In w-s curve, suction will increase with decrease moisture content,...
This article is based on the structural linear fatigue frequency domain analysis method of power spectral density function, taking a single launch vehicle equipment as object. Based actual flight telemetry high-frequency random acceleration vibration data at installation position equipment, non-stationary segmented and processed to obtain total life damage key parts throughout flight. principle equivalence, envelope spectrum for whole has been optimized reduced, acceptance level conditions...