A5104085084- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Chemokine receptors and signaling
- Reproductive Biology and Fertility
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Nerve injury and regeneration
- Pancreatic function and diabetes
- Plant and Fungal Species Descriptions
- MicroRNA in disease regulation
- Botanical Research and Chemistry
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- Medicinal Plants and Bioactive Compounds
- Bladder and Urothelial Cancer Treatments
Jishou University
2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Shenzhen University
2025
Soochow University
2024
Nanjing Agricultural University
2022-2024
Jiangsu Province Hospital
2021
Nanjing Medical University
2017-2021
Ministry of Education of the People's Republic of China
2011
Background: Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types cancer and miR-675 reported to be embedded H19's first exon. However, their function specific mechanisms action have not been fully elucidated. The aim this study was identify novel lncRNA-microRNA-mRNA functional network gastric cancer. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) used assess relative expression normal (GES-1) cell lines...
P21-activated kinase 1 (PAK1) is a critical downstream target that mediates the effect of small Rho GTPase on regulation cytoskeletal kinetics, cell proliferation, and migration. PAK1 has been identified as crucial regulator spindle assembly during first meiotic division; however, its roles metaphase I (MI) to II (MII) transition in oocytes remain unclear. In present study, potential function regulating microtubule organization positioning MI-MII was addressed porcine oocytes. The results...
<p>Figure S1. The gating strategy utilized in flow cytometric analysis of immune cells.</p>
<p>Figure S9. Pharmacologic inhibition NAC1 by NIC3 potentiates anti–PD-1 therapy.</p>
<p>Table S2. Primers used for CRISPR/Cas9 gene editing system, qRT-PCR and ChIP in this study</p>
<p>Figure S4. NAC1 increases MDSCs infiltration and suppresses anti-tumor immunity.</p>
<p>Table S3. Gene expression matrix of TCGA-OV cohort</p>
<p>Figure S2. Tumoral expression of NAC1 promotes ovarian cancer progression in immunocompetent mice.</p>
<p>Figure S8. The levels of CXCR6 mRNA in MDSCs.</p>
<p>Figure S6. KEGG pathway and GO (Gene Ontology) term analysis of cytokine antibody microarray.</p>
<p>Table S1. The details of the clinical sample for IHC analysis.</p>
<p>Figure S7. NAC1 induces MDSCs recruitment via the CXCL16-CXCR6 axis.</p>
<p>Table S5. Statistical data on NAC1 expression in relation to clinic-histopathologic features for surgical ovarian tumor specimens.</p>
<p>Figure S5. The number of CD45+CD4+ cells and the percentage CD45+CD4+IFNγ+ show slight changes between ID8-Control ID8-NIC3 subcutaneous tumors.</p>
<p>Supplementary R package</p>
<p>Table S4. Clinical information of TCGA-OV cohort.</p>
<p>Figure S3. the bioinformatics analysis of human ovarian tumor samples from TCGA data and Kaplan–Meier survival curves orthotopic immunocompetent C57BL/6 tumor-bearing mice.</p>
<p>Table S6. Statistical data on CXCL16 expression in relation to clinic-histopathologic features for surgical ovarian tumor specimens.</p>
<div>Abstract<p>Epithelial ovarian cancer is the most common type of with a low rate response to immunotherapy such as immune checkpoint blockade therapy. In this study, we report that nucleus accumbens–associated protein 1 (NAC1), putative driver epithelial cancer, has critical role in evasion. We showed murine models depleting or inhibiting tumoral NAC1 reduced recruitment and immunosuppressive function myeloid-derived suppressor cells (MDSC) tumor microenvironment, led...
Ohwialuteola (H. Ohashi & T. Nemoto) H. is only known from one collection in Yunnan Province, China. It has not been recollected since its last 1972. Here, we report the rediscovery of species that means first new record Hunan Based on fresh material, present a revised morphological description O.luteola and conducted sequencing assembly plastid genome. Morphologically, similar to O.caudata, but former can be easily distinguished by leaflets length/width ratio ranging 2.5 3.6, apex acute...
Bladder cancer, a common malignancy of the urinary tract, presents complex therapeutic challenges, thereby necessitating exploration innovative treatment strategies. This study introduces novel, self-propelled nanomedicine delivery system that forms nanoparticles within bladder lumen by co-infusing dopamine hydrochloride, Mn2+, cGAMP, and urease into to initiate in situ polymerization. The resulting Mn-cGAMP@PDA-urease (DMCU) possess urease-modified surface, which acts as an engine generate...
P21-activated kinase 1 (PAK1), as a member of the PAK family, has been implicated in various functions during somatic mitosis; however, less is known about its role oocyte meiosis. Herein, we highlight indispensable PAK1 regulating spindle assembly and cell cycle progression first meiotic division porcine oocytes. First, found that activated expressed dynamically, subcellular localization was tightly associated with dynamics meiosis Specific inhibition activity by inhibitor targeting...
Abstract Epithelial ovarian cancer (EOC) is the most common type of with a low rate response to immunotherapy such as immune checkpoint blockade (ICB) therapy. Here, we report that nucleus accumbens-associated protein 1 (NAC1), putative driver EOC, has critical role in evasion. We showed murine models depleting or inhibiting tumoral NAC1 reduced recruitment and immunosuppressive function myeloid-derived suppressor cells (MDSCs) tumor microenvironment (TME), led significant increases...