A5046225359- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Iron Metabolism and Disorders
- Virus-based gene therapy research
- Hemoglobinopathies and Related Disorders
- Animal Disease Management and Epidemiology
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Vector-Borne Animal Diseases
- interferon and immune responses
- Organ Transplantation Techniques and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- High Altitude and Hypoxia
- Prenatal Screening and Diagnostics
- Calibration and Measurement Techniques
- Advanced Sensor Technologies Research
- Neonatal Respiratory Health Research
- Biochemical effects in animals
- Hematopoietic Stem Cell Transplantation
- Abdominal Surgery and Complications
- Viral Infections and Immunology Research
Shenzhen University
2020-2025
Xiamen University
2019-2024
Institute of Soil and Water Conservation
2024
Northwest A&F University
2024
Huazhong Agricultural University
1994-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2019-2024
North University of China
2024
Sichuan University
2013-2024
Shandong First Medical University
2023-2024
Jinan Central Hospital
2023-2024
Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with progression multiple malignancies. But, underlying mechanisms by which has_circ_0032627 (circDLST) contributed to gastric cancer (GC) remain undocumented. The expression and cellular localization circDLST its association clinicopathological characteristics prognosis in patients GC was analysed using fluorescence situ hybridization. Gain- loss-of-function experiments as well a subcutaneous...
African swine fever virus (ASFV) is a large, double-stranded DNA that causes fatal disease in pigs, posing threat to the global pig industry. Whereas some ASFV proteins have been found play important roles ASFV-host interaction, functional of many are still largely unknown. In this study, we identified I73R, an early viral gene replication cycle ASFV, as key virulence factor. Our findings demonstrate pI73R suppresses host innate immune response by broadly inhibiting synthesis proteins,...
Background: The goal of the present study was to investigate wound-healing potential marine collagen peptides (MCPs) from chum salmon skin administered rats following cesarean section (CS).Methods: Ninety-six pregnant Sprague-Dawley were randomly divided into four groups: a vehicle group and three MCP groups. After CS, intragastrically given MCPs at doses 0, 0.13, 0.38, 1.15 g/kg*bw, respectively. On postoperative days 7, 14, 21, uterine bursting pressure, tensile strength, hydroxyproline...
Abstract Background Observational studies have indicated a potential link between gut microbiota and sarcopenia. However, the underlying mechanisms causal relationship not been established. Thus, objective of this study is to examine possible association sarcopenia-related traits, including low hand-grip strength appendicular lean mass (ALM), shed light on gut–muscle axis. Methods To investigate impact ALM, we utilized two-sample Mendelian randomization (MR) approach. Summary statistics were...
As the building blocks of nucleic acids, nucleotides are conditionally essential nutrients that exhibit multifaceted activities. The present study aimed to evaluate anti-fatigue effects dietary (NTs) on mice and explore possible underlying mechanism. Mice were randomly divided into four experimental sets detect different indicators. Each set was then groups: (i) one control group (ii) three NTs groups, which fed diets supplemented with at concentrations 0%, 0.04%, 0.16%, 0.64% (wt/wt). could...
Abstract Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; mainly responsible for somatic cells during mitosis while only works meiosis germ cells. This spatiotemporal difference probably due to their distinctive mismatch tolerance HR: does not permit HR presence of mismatches, whereas can tolerate certain mismatches. Here, cryo-EM structures Rad51–DNA Dmc1–DNA complexes...
Bladder cancer, a common malignancy of the urinary tract, presents complex therapeutic challenges, thereby necessitating exploration innovative treatment strategies. This study introduces novel, self-propelled nanomedicine delivery system that forms nanoparticles within bladder lumen by co-infusing dopamine hydrochloride, Mn2+, cGAMP, and urease into to initiate in situ polymerization. The resulting Mn-cGAMP@PDA-urease (DMCU) possess urease-modified surface, which acts as an engine generate...
The aim of the present study was to analyze and summarize clinicopathological characteristics large-cell lung carcinoma (LCLC) lung, in order improve definite diagnosis rate LCLC. Clinicopathological data 174 patients with LCLC, confirmed pathologically, were retrospectively reviewed. cases LCLC accounted for 5.7% total cancer during corresponding time period at Affiliated Cancer Hospital Tianjin Medical University (Tianjin, China), among which there 131 males 43 females an average age 61.4...
Intratumor heterogeneity (ITH) leads to an underestimation of the mutational landscape portrayed by a single needle biopsy and consequently affects treatment precision. The extent colorectal cancer (CRC) genetic ITH is not well understood in Chinese patients. Thus, we conducted deep sequencing using OncoGxOne™ Plus panel, targeting 333 cancer-specific genes multi-region biopsies primary liver metastatic tumors from three CRC We determined that varied among cases. On average, 65% all...
There are errors in Figs 1D and 3C.The incorrect reference protein blot images were included for Fig 1D; IB: α-tubulin
Background: In recent years, immunotherapy has changed the therapeutic landscape of hepatocellular carcinoma (HCC). Since efficacy is closely related to tumor microenvironment (TME), in this study, we constructed a prognostic model based on TME predict prognosis and effect HCC patients. Methods: Transcriptome follow-up data 374 patients were acquired from TCGA Cancer Genome Atlas (TCGA) database. The immune/stromal/estimate scores (TME scores) purity calculated using ESTIMATE algorithm...
Transmissible gastroenteritis virus (TGEV) is the etiologic agent of transmissible in pigs, and N-terminal domain TGEV spike protein generally recognized as both virulence determinant enteric tropism determinant. Here, we assembled a full-length infectious cDNA clone bacterial artificial chromosome. Using novel approach, clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) systems efficiently rapidly rescued another recombinant with 224-amino-acid...
Objective Interferon (IFN)‐1 signatures are a hallmark of patients with systemic sclerosis (SSc). However, its significance in clinical stratification and contribution to deterioration still need be better understood. Methods For hypothesis generation, we performed single‐cell RNA sequencing (scRNA‐seq) on skin biopsies (four SSc two controls) using the BD Rhapsody platform. Two publicly available data sets scRNA‐seq were used for validation (GSE138669: 12 diffuse cutaneous [dcSSc] 10...
Sarcopenia is a significant geriatric syndrome that involves the loss of skeletal muscle mass and strength. Due to its substantial endocrine role, metabolic microenvironment undergoes changes with age. Examining pathogenesis sarcopenia through focusing on dysregulation could offer insights for developing more effective intervention strategies. In this study, we analyzed transcriptomics data identify specific genes involved in regulation metabolism during development sarcopenia. Three machine...
Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role a number of edema-associated diseases. Qing Yin Tang (QYT), traditional Chinese medicine, has been shown to effectively reduce the mortality rate acute injury (ALI) induced by severe pancreatitis (SAP). The current study aimed investigate detailed mechanisms underlying effects QYT on ALI SAP, particularly expression levels tissue. was established Wister rats who were...