A5101555552- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Traditional Chinese Medicine Studies
- Dermatologic Treatments and Research
- Cardiovascular Health and Disease Prevention
- Bone health and treatments
- Mechanical Circulatory Support Devices
- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 detection and testing
- Bone and Joint Diseases
- Transplantation: Methods and Outcomes
- Connective Tissue Growth Factor Research
- Cardiovascular and Diving-Related Complications
- Biosensors and Analytical Detection
- Renal function and acid-base balance
- Renal cell carcinoma treatment
- Hemodynamic Monitoring and Therapy
- Kidney Stones and Urolithiasis Treatments
- Ferroptosis and cancer prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Ureteral procedures and complications
- MRI in cancer diagnosis
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Parathyroid Disorders and Treatments
Wenzhou Medical University
2023-2025
Wenzhou Central Hospital
2023-2025
Ruian People's Hospital
2024
Sun Yat-sen University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Affiliated Hospital of Nantong University
2023
Nantong University
2023
Second Affiliated Hospital of Nantong University
2023
Renji Hospital
2018-2023
Shanghai Jiao Tong University
2023
Background: Homer scaffold protein 1 (homer1) may harbor neuroprotective effects against acute brain injury. This study aimed to investigate the prognostic role of serum homer1 in human aneurysmal subarachnoid hemorrhage (aSAH). Methods: A total 209 patients with aSAH and 100 controls were encompassed this prospective cohort study. Serum levels quantified at admission all patients, on post-aSAH days 1, 3, 5, 7, 10, 14 83 recruitments controls. The modified Fisher scale (mFisher) World...
Objective Interferon (IFN)‐1 signatures are a hallmark of patients with systemic sclerosis (SSc). However, its significance in clinical stratification and contribution to deterioration still need be better understood. Methods For hypothesis generation, we performed single‐cell RNA sequencing (scRNA‐seq) on skin biopsies (four SSc two controls) using the BD Rhapsody platform. Two publicly available data sets scRNA‐seq were used for validation (GSE138669: 12 diffuse cutaneous [dcSSc] 10...
In the current practice, graft ischaemia and reperfusion injury (IRI) is considered an inevitable component in organ transplantation, contributes to compromised quality, inferior survival limitations availability. Among all donor organs, heart most vulnerable IRI tolerated ischaemic time shortest.By combining adapted surgical techniques normothermic machine perfusion (NMP), we performed first case of ischaemia-free beating transplantation (IFBHT) man. The was procured after situ NMP circuit...
Developing a simple and highly sensitive approach for
This study was undertaken to evaluate the feasibility, safety, and therapeutic effects of percutaneous renal cryoablation under local anesthesia with conscious sedation for patients who have unresectable stage 1 (T1NoMo) cell carcinoma (RCC) in high surgical risk. Eighteen were not candidates surgery underwent primary cryosurgery guided by gray-scale ultrasound. Contrast-enhanced ultrasonography (CEUS) contrast-enhanced computed tomography (CT) performed treatment at completion. The mean...
Our study aims to explore the changes of cerebrovascular reactivity (CVR) in migraineurs with right-to-left shunts (RLS), and further evaluate association between CVR occurrence white matter hyperintensities (WMHs).RLS was diagnosed based on a contrast enhancement transcranial Doppler (c-TCD) examination. The breath holding index (BHI), which represents CVR, measured from middle cerebral artery (MCA) using TCD breath-holding method. WMHs defined as clearly hyperintense areas 3 T magnetic...
Abstract Background Significant hemodynamic changes occur during liver transplantation, emphasizing the importance of precious and continuous monitoring cardiac output, index, other parameters. Although output by pulse indicator (PiCCO) was statistically homogeneous compared to clinical gold standard pulmonary artery catheterization (PAC) in previous studies there are fewer statistical methods for assessment its conclusions, a lack comparisons parameters (e.g., SVRI, systemic vascular...
Abstract Background As the most prevalent primary brain tumor in adults, glioma accounts for majority of all central nervous system malignant tumors. The concept PANoptosis is a relatively new, underlining interconnection and synergy among three distinct pathways: pyroptosis, apoptosis necroptosis. Methods We performed single‐cell annotations cells determined crucial signaling pathways through cell chat analysis. Using least absolute shrinkage selection operator (LASSO) Cox analyses, we...
Objective To observe the clinical effect of xuefuzhuyu decoction combined with amlodipine on blood stasis type hypertension.Methods The patients hypertension were randomly divided into treatment group and control group,with 30 cases in each group.The treated amlodipine,and given addition,applied for 4 weeks.The antihypertensive efficacy,blood pressure,syndrome integral,blood fat index three observed before after treatment.Results pressure levels decreased significantly both groups(P...
This study reports a low dose combination therapy of cyclophosphamide (CYC) and pirfenidone (PFD) the efficiency safety in refractory connective tissue disease associated interstitial lung (CTD-ILD) patients.The included seven CTD-ILD patients (2 males, 5 females; mean age 48.8 years; range, 32 to 63 years) treated between January 2016 December 2017 our clinic. At enrolment, all had shown no improvement their symptoms (dyspnea or cough) after at least one month high steroids treatment....
Objective To further study the physiological application of Tsinghua Germans encephalopathy treatment for brain injury patients in clinical rehabilitation period.Methods 120 cases were randomly divided into group (ie,combined with conventional and therapeutic equipment) control (conventional therapy only) averagely.Patients' moving was compared between two groups.Results The total effective rate 95％,while group' s 77％; there significant differences.The effect markedly greater than...
<h3>Background</h3> There are anti-inflammation and anti-fibrosis agents available for connective tissue disease associated interstitial lung (CTD-ILD). A clinical study has been initiated to assess the combination of two (NCT03221257), but whether they can spare dose each other is unknown. <h3>Objectives</h3> This preliminary aimed observe outcomes CTD-ILD patients receiving cyclophosphamide plus pirfenidone as a rescue therapy, with agent at about one third routine dosage. <h3>Methods</h3>...
To the Editor: Takayasu arteritis (TA), a non-specific large-vessel vasculitis characterized by granulomatous inflammation of vascular walls,[1] has been reported main cause for 53% aortitis.[2] TA with aortitis, involving aorta, aortic root (ring and sinus), valves, may lead to heart failure mortality attributed stenosis or dilation, aneurysm dissection, valve insufficiency, perivalvular leakage, so on.[3] Medication treatments (glucocorticoids, traditional immunosuppressive agents and/or...