A5106073671- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
- NF-κB Signaling Pathways
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- Cerebrovascular and Carotid Artery Diseases
- RNA modifications and cancer
- Inflammasome and immune disorders
- Virus-based gene therapy research
- HIV Research and Treatment
- Neurological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Signaling Pathways in Disease
- Infectious Diseases and Tuberculosis
Institut Pasteur of Shanghai
2012-2020
Shanghai Institutes for Biological Sciences
2012-2020
Center for Excellence in Molecular Cell Science
2017-2020
Shanghai Jiao Tong University
2018-2020
Chinese Academy of Sciences
2011-2018
Biochemical Society
2012
University of Perugia
2012
RORγt is a key transcription factor that controls the development and function of inflammatory Th17. The mechanisms regulate stability remain unclear. We report Th17 cells highly express deubiquitinase ubiquitin-specific protease (USP)4, which essential for maintaining cell function. Inhibition catalytic activity USP4 with vialinin A, compound derived from Chinese traditional medicine, dampened differentiation. interacted deubiquitinated K48-linked polyubiquitination RORγt, thereby promoting...
Article9 July 2020Open Access Source DataTransparent process The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation Jing Yang Shanghai Institute of Immunology and Department Microbiology, Jiao Tong University School Medicine, University, Shanghai, China Search for more papers this author Ping Wei Otolaryngology, Ministry Education Key Laboratory Child Development Disorders, National Clinical Research Center Health Disorders (Chongqing),...
Abstract T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor Th17 cell differentiation through direct transcriptional activation interleukin 17(A) (IL-17). How RORγt itself regulated remains unclear. Here, we report that p300, which has histone acetyltransferase (HAT) activity, interacts with...
Abstract The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It established that GATA-3 induced in Treg under inflammatory conditions. stabilizes levels to avoid into inflammatory-like cells. IL-6 signal pathway influences sensitivity towards instability. mechanism regulating its relation remains unclear. Here we report how miR-125a-5p plays an important role conversion by IL-6. expression low steady state conditions can be inhibit...
The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such herpes virus. Inhibition of was found to block viral genome transcription and lytic replication viruses. However, RNA virus genomes do not rely on chromatin structure association, the role activity in infections is anticipated. Here, we identify that, contrary its enhancing replication, limits by demethylating activating IFITM3 which host restriction factor many We have that recruited...
There are errors in Figs 1D and 3C.The incorrect reference protein blot images were included for Fig 1D; IB: α-tubulin
Nuclear factor of activated T cells (NFAT) is an important regulator cell activation. However, the molecular mechanism whereby NFATc2 regulates IL2 transcription not fully understood. In this study, we showed that ubiquitin‐specific protease 22 (USP22), known as a cancer stem marker, specifically interacted with and deubiquitinated NFATc2. USP22 stabilized protein levels, which required its deubiquitinase activity. Consistent these observations, depletion in reduced expression IL2, cytokine...
The abundant expression of IFNγ in Th-inducing POK (ThPOK)-deficient CD4(+) T cells requires the activation Eomesodermin (Eomes); however, underlying mechanism this phenomenon remains unclear. Here we report that ThPOK binds directly to promoter region Eomes gene repress its cells. We identified histone acetyltransferase TIP60 as a co-repressor ThPOK-target genes, where ectopically expressed increased protein stability by promoting acetylation at Lys(360) residue then augment transcriptional...
Antibiotics are widely given for surgical patients to prevent infection. Because of the lack study on rational use antibiotics in with human immunodeficiency virus (HIV) -infected during procedures, we analyzed risk factors affecting postoperative infectious complications HlV-infected and explore perioperative antibiotics.This retrospective consisted 308 patients, 272 males 36 females, who had undergone operation at Shanghai Public Health Clinical Center from November 2008 April 2012. The...
Rationale : Endovascular implantation may lead to mechanical injury of the vessel walls, their inflammation and subsequent formation a thrombus in stented portion vessel, as well endothelial growth restenosis. Intimal changes potential damaged area from negative positive. Aim To demonstrate efficacy corrective charge on stent surface after its endovascular reduction risk thrombosis Materials methods With terminal element technique we created model for distribution electrostatic potentials...
Abstract In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or drug to treat COVID-19, positive results passive immune therapy using convalescent serum provides strong lead. We have developed new class tetravalent, biparatopic therapy, 89C8-ACE2. It combines specificity monoclonal antibody (89C8) that recognizes relatively conserved N-terminal domain (NTD) viral S glycoprotein, and ectodomain ACE2, which binds receptor-binding (RBD) S. This molecule shows...