A5052090282- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Renal and related cancers
- Tissue Engineering and Regenerative Medicine
- Lymphatic Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Cancer, Stress, Anesthesia, and Immune Response
- Connective Tissue Growth Factor Research
Harbin Medical University
2013-2024
First Affiliated Hospital of Harbin Medical University
2013-2024
Beijing Shijitan Hospital
2021-2024
Capital Medical University
2021-2024
SMYD2 is a histone methyltransferase that has been reported to be an important epigenetic regulator. This study aims investigate as prognostic indicator of clear cell renal carcinoma (ccRCC) and explore its role in tumorigenesis multi-drug resistance. Methods: Tumor specimens, clinicopathologic information, outcomes 186 ccRCC patients from three hospitals China were collected for immunohistochemistry staining, Kaplan-Meier analysis, Cox proportional hazards-regression analysis. MicroRNA...
Arsenic trioxide has shown remarkable biological activity against bladder cancer in some clinical studies. However, the mechanism of its action is unknown. Our aim was to find relationship between miRNAs and arsenic treatment by using T24 human carcinoma cells. By performing microRNA microarray quantitative real-time PCR after ATO treatment, we found that expression levels several miRNAs, particular, miRNA-19a, were significantly decreased cell line. Furthermore, proliferation assay, flow...
Previous studies have suggested that lycopene has cytotoxic effects in a variety of types human cancer. An improved understanding the mechanisms underlying anticancer may provide novel therapeutic targets for cancer treatment. PC3 cells were treated with different concentrations 24 and 48 h, level protein kinase B (AKT2) was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting. Additionally, expression levels microRNA (miR)‑let‑7f‑1 measured...
This study was conducted to analyze the expression of ubiquitin-specific protease Usp28 and assess its clinical significance in human bladder cancer. mRNA protein levels were determined by real-time polymerase chain reaction (PCR) Western blot 24 paired cancers adjacent non-cancerous tissues. In addition, 186 also immunohistochemistry. The relationship between clinico-pathologic features prognosis finally evaluated. expressed at a higher level compared tissues both samples (all P < 0.01)....
Abstract Many patients with prostate cancer (PCa) cannot be diagnosed until an advanced stage, which make PCa become a large threat to human health. It is urgent need explore novel biomarkers for accurate diagnosis and targets the effective treatment of PCa. This study aimed investigate effects RAB3D (which belongs secretory Rab GTPases) on progression The results showed that was highly expressed in tissues compared normal according gene expression omnibus dataset. Consistent bioinformatics...
ObjectivePhysical activity-related interventions alleviate the severity of erectile dysfunction (ED), but it is unknown whether recommended volume physical activity (PA) or a higher level reduces likelihood ED in adult males. We aimed to evaluate association between PA and among US male adults.DesignA nationally representative cross-sectional survey.SettingNational Health Nutrition Examination Survey 2001–2004.ParticipantsA total 2509 men aged ≥20 years were enrolled.Primary secondary...
Abstract: Renal cell carcinoma (RCC) is a common type of kidney cancer. Normally, surgical treatment can prolong life, but only for patients with early stage tumors. However, it difficult detection strategies to distinguish between benign and malignant Therefore, potential biomarkers diagnosis prognosis RCC are needed. Intriguingly, mounting evidence has demonstrated that many long noncoding RNAs (lncRNAs) strongly linked cancers. Indeed, promising RCC-associated lncRNA have also been...
Oxymatrine (OMT) has been identified to possess immunomodulatory, antiinflammatory and anticancer properties. This study aimed investigate its precise function the underlying molecular mechanisms in renal cell carcinoma progression. The antineoplastic effect of oxymatrine was investigated by CCK-8 assay, cycle analysis, apoptosis wound healing experiment, transwell drug-sensitivity analysis cancer cells following treatment. modulation on β-catenin analyzed through western blot...
<i>Objective:</i> Arsenic trioxide (ATO) is a potent antitumor agent used to treat acute promyelocytic leukemia, and recently solid tumors including bladder cancers. However, mechanism explain its activity in cancers unclear. Here, we investigated the role of protein kinase C (PKC) ATO-induced apoptosis inhibition proliferation cancer cells. <i>Methods:</i> T24 human carcinoma cells were incubated with different concentrations ATO presence or absence PMA (PKC...
The aim of the present study was to identify potential key genes and single nucleotide variations (SNVs) in prostate cancer. RNA sequencing (RNA‑seq) data, GSE22260, were downloaded from Gene Expression Omnibus database, including 4 cancer samples normal tissues samples. RNA‑Seq reads processed using Tophat differentially-expressed (DEGs) identified Cufflinks package. Ontology enrichment analysis DEGs performed. Subsequently, Seqpos used upstream regulatory elements DEGs. SNV analyzed Genome...
To report our initial experience dealing with retroperitoneal laparoscopic partial nephrectomy (LPN) for tumors larger than 7 cm in renal cell carcinoma (RCC).A total of 15 patients malignant underwent LPN at institution. Patient baseline demographics, perioperative outcomes, pathological characteristics, and estimated glomerular filtration rate (eGFR) were analyzed retrospectively collected database.The tumor size is 7.5 (7.1-9.0) cm. Nine (60.00%) patients, 4 (26.67%) 2 (13.33%) suffered...
To analyze the clinical characteristics and diagnosis of 2 cases with diffuse pulmonary lymphatic disease.Clinical manifestations children were retrospectively analyzed. Two patients both from Beijing Children Hospital in 2013 2014.Diffuse disease was diagnosed by pathology pleura case 1 lymphoscintigraphy 2.The first patient a male aged 10-year-5-month who presented history pleural effusion for years. Examination revealed chylothorax pericardial effusion. After decortications ligation...
Clear cell renal carcinoma (ccRCC) is the most common type of malignant tumor in kidney. With numbers patients whose physical condition or stage not suitable for radical surgery, they only have a narrow choice using VEGF/mTOR targeted drugs to control their tumors, but ccRCC often shows resistance these drugs. Therefore, identifying new therapeutic target urgent necessity. In this study, first time, we concluded from bioinformatics analyses and vitro research that FK506 binding protein 10...
To investigate the characteristics, diagnosis and therapeutic effect of acquired lymphangiectasia vulva (ALV).