A5101793670- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Polyomavirus and related diseases
- Peptidase Inhibition and Analysis
- Face and Expression Recognition
- Congenital Diaphragmatic Hernia Studies
- Ultrasound in Clinical Applications
- Cardiac Structural Anomalies and Repair
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cardiac Valve Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Machine Learning and ELM
- Pulmonary Hypertension Research and Treatments
- Medical Research and Treatments
- Neural Networks and Applications
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Immune Cell Function and Interaction
Jiangxi Provincial Cancer Hospital
2020-2025
National Clinical Research
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Weatherford College
2021
Chongqing University
2006
University of Miami
2004
Background: Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small-cell lung cancer that predominantly affects younger, non-smoking individuals in southern and southeast Asia, where Epstein–Barr virus (EBV) prevalence high. The efficacy safety immunotherapy pLELC, especially second-line settings, remain inadequately explored. Objectives: This study aimed to evaluate the immunotherapy, either alone or combination with chemotherapy, improving progression-free...
To date, no specific studies have reported the use of dynamic serum tumor markers (STMs) as prognostic factors in patients with advanced non-small-cell lung cancer (NSCLC) who receive first-line immunotherapy. Therefore, it is unclear whether STMs can be used a factor for immunotherapy NSCLC.To elucidate role monitoring response NSCLC. Patients were treated programmed cell death-1/programmed death ligand-1 inhibitors at four Chinese centers.This was multicenter retrospective study.Blood...
To evaluate the efficacy of pentoxifylline (PTXF) in attenuation lung inflammation during volume-induced injury (VILI) newborn piglets, 17 piglets were mechanically ventilated with a large tidal volume (50 ml/kg) for period 8 h. They randomly assigned to placebo (PL, n = 9) or treatment group (PTXF, 8) that received PTXF (20 mg/kg as bolus, followed by continuous infusion 5 mg/kg/h). Hemodynamics, mechanics and arterial blood gases measured h study. Serum tracheoalveolar fluid (TAF)...
ABSTRACT Background: Compared with other lung squamous cell carcinomas (LUSC), pulmonary lymphoepithelioma-like carcinoma (pLELC) is closely associated Epstein–Barr virus (EBV) infections a unique molecular profile and immune microenvironment. This study was thus established to compare the treatment response effectiveness of immunotherapy between pLELC LUSC. Material Methods: We enrolled 31 patients 116 LUSC receiving first-line at three centers in China compared immunotherapy. Propensity...
e13527 Background: Exon 19 deletions and exon 21 L858R substitutions are the most common mutations of epidermal growth factor receptor (EGFR) in cancers, remaining other called uncommon mutations. Recent studies have shown clinical relevance EGFR with tyrosine kinase inhibitors (TKI) therapies immunotherapies. Therefore, understanding distribution characteristics cancers would provide evidence for future design trials drug development. Methods: Next-generation sequencing data were obtained...
Abstract Compared with other lung squamous cell carcinomas (LUSC), pulmonary lymphoepithelioma-like carcinoma (pLELC) is closely associated Epstein–Barr virus infections a unique molecular profile and immune microenvironment. The purpose of this study was therefore to compare the treatment response effectiveness immunotherapy between pLELC LUSC. We enrolled 31 patients 116 LUSC receiving first-line at three centers in China compared immunotherapy. Propensity score matching (PSM) used balance...
Objective To evaluate the preoperative right ventricular ejection fraction (RVEF) as a predictor of postoperative complications after lung resection. Methods RVEF was consecutively assessed in 254 patients before pulmonary resection by echocardiography. According to function, were divided into: group Ia (n=82, RVEF≥45%), Ib (n=92,RVEF < 45%), Ic (n=42, 40%),and Id (n=38, RVEF≤35%). Postoperative detected again 122 3 weeks later Results Preoperative with significantly higher than that...
Abstract BackgroundGastric carcinoma (GC) is a highly aggressive malignancy and associated with high morbidity mortality rates around the world, current tumor-node-metastasis (TNM) staging system inadequate to predict overall survival (OS) in GC patients. therefore, potential forecasting methods for prognosis are important investigate.MethodsDifferentially expressed genes (DEGs) were screened using gene expression data from The Cancer Genome Atlas (TCGA). We then construct risk score...