A5084450719- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Advanced Biosensing Techniques and Applications
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Breast Implant and Reconstruction
- Molecular Biology Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
Shanghai Cancer Institute
2024
Fudan University Shanghai Cancer Center
2021-2024
Shanghai Medical College of Fudan University
2021-2024
Ruijin Hospital
2018-2022
Shanghai Jiao Tong University
2009-2021
Weatherford College
2020
Renji Hospital
2020
Sun Yat-sen University
2016-2018
Shanghai Ninth People's Hospital
2017
Tea Research Institute
2009
HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all cancers. Recent studies have suggested a group heterogeneous diseases with different sensitivities standard treatment regimens. Revealing the molecular heterogeneity could potentially enable more precise strategies. In this study, we performed multiomics profiling on cohort and identified four transcriptome-based subtypes. The classical HER2 (HER2-CLA) comprised 28.3% samples displayed high ERBB2...
Metastatic breast cancer (MBC) is a highly heterogeneous disease and bone one of the most common metastatic sites. This retrospective study was conducted to investigate clinical features, prognostic factors benefits surgery patients with initial metastases.From 2010 2015, 6,860 diagnosed metastasis were analyzed from Surveillance, Epidemiology, End Results (SEER) database. Univariate Multivariable analysis used identify factors. A nomogram performed based on selected cox regression result....
More than half of the breast cancer initially labeled as human epidermal growth factor receptor 2 (HER2)-negative actually exhibited low HER2 levels (IHC 1+ or IHC 2+/FISH-) and were classified HER2-low cancer. Previous research emphasized significant biological heterogeneity in cancer, highlighting importance accurately characterizing tumors to promote precise management antibody‒drug conjugates. In this study, we established a large-scale targeted sequencing cohort (N = 1907) representing...
Abstract Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially non-Caucasians, remains poorly characterized. We performed large-scale prospective targeted sequencing of matched tumor-blood samples from 4079 Chinese females, coupled detailed clinical annotation, to map between germline somatic alterations. discovered 368 pathogenic variants identified 5 cancer DNA repair-associated genes (BCDGs;...
// Wang Li 1, * , Yutong Bai 2, Ming Wu 2 Lujun Shen 1 Feng Shi Xuqi Sun Caijin Lin Boyang Chang Changchuan Pan 3 Zhiwen and Peihong Department of Medical Imaging Interventional Radiology, Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, Guangdong 51060, P. R. China Zhong Shan School, University, Guangzhou 510080, People's Republic Oncology, Sichuan Hospital Institute, Second Province, Chengdu, 610041,...
This paper investigates the resource allocation problem in downlink of OFDMA cooperative relaying networks with one source (base station) and multiple relay destination nodes. Assuming that base station knows all instantaneous channel gains links, we propose a dynamic joint subchannel power (SPA) scheme whose objective is to maximize worst user's data rate constraint total transmission power. Since optimal solution this combinatorial extremely computationally complex, low-complexity...
Despite the rapid growing of cancer survivors, prior history is a commonly adopted exclusion criterion. Whether will impact survival patients with advanced breast (ABC) remains uncertain.Patients ABC diagnosed between 2004 and 2010 were identified using Surveillance, Epidemiology, End Results (SEER) database. Timing, stage, type used to characterize cancer. Multivariable analyses propensity score-adjusted Cox regression competing risk conducted evaluate prognostic effect on overall (OS)...
Patients with de novo metastatic breast cancer (MBC) constitute a heterogeneous group different clinicopathologic characteristics and survival outcomes. Despite controversy regarding its prognostic value, primary tumor surgery may improve for selected patients.Patients MBC were identified using the SEER database then divided randomly into training validation sets. A Fine-Gray competing risks model was developed to identify variables associated increased cancer-specific mortality in set. The...
Objective: Mammographic calcifications are a common feature of breast cancer, but their molecular characteristics and treatment implications in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) cancer remain unclear. Methods: We retrospectively collected mammography records an HR+/HER2− cohort (n = 316) with matched clinicopathological, genomic, transcriptomic, metabolomic data. On the basis mammographic images, we grouped tumors by calcification...
<div>Abstract<p>HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all cancers. Recent studies have suggested HER2-positive a group heterogeneous diseases with different sensitivities standard treatment regimens. Revealing the molecular heterogeneity could potentially enable more precise strategies. In this study, we performed multiomics profiling on cohort and identified four transcriptome-based subtypes. The classical HER2 (HER2-CLA) comprised...
Despite the high prevalence of mammographic calcifications, our understanding remains limited regarding clinical and molecular features calcifications within triple-negative breast cancer (TNBC). To investigate relevance biological basis TNBC with suspicion for malignancy, we established a study cohort (N = 312) by integrating records data genomic, transcriptomic, metabolomic profiling. similar clinicopathological features, patients highly suspicious exhibited worse overall survival than...
Background: Breast cancer has the highest incidence and mortality rates among women worldwide. Hormone receptor (HR)+/human epidermal growth factor 2 (HER2)− breast is most common molecular subtype, accounting for 50–79% of cancers. Deep learning been widely used in image analysis, especially predicting targets related to precise treatment patient prognosis. However, studies focusing on therapeutic target prognosis HR+/HER2− are lacking. Methods: This study retrospectively collected...
Purpose: The objective of this study was to evaluate the American Joint Committee on Cancer (AJCC) pathological prognostic stage among patients with invasive ductal carcinoma (IDC) and lobular (ILC) propose a modified score system if necessary. Methods: Women diagnosed IDC ILC during 2010-2015 in Surveillance, Epidemiology, End Results (SEER) database were retrospectively identified. Disease-specific survival (DSS) overall (OS) estimated by Kaplan-Meier method. Predictive performances...
This retrospective study aimed to evaluate the distribution pattern and prognostic value of 21-gene recurrence score (RS) in Chinese patients with mucinous breast cancer (MC) compared infiltrating ductal carcinoma (IDC).Patients diagnosed MC or IDC from January 2010 2017 were retrospectively recruited. Reverse transcriptase-polymerase chain reaction assay 21 genes was conducted calculate RS. Univariate multivariate analyses performed assess association between RS clinicopathological factors....
Background: In adjuvant settings, epirubicin and cyclophosphamide (EC) docetaxel (TC) are both optional chemotherapy regimens for lymph node-negative, hormone receptor (HR)-positive, human epidermal 2 (HER2)-negative breast cancer patients. Neutropenia is one of the most common adverse events (AEs) these regimens. The rate grade 3−4 neutropenia varies in different studies, direct comparisons safety profiles between EC TC lacking. Method: ELEGANT (NCT02549677) a prospective, randomized,...
To retrospectively compare the outcome of chemolipiodolization with or without embolization in transcatheter arterial chemoembolization (TACE) combined radiofrequency ablation (RFA) Patients hepatocellular carcinoma (HCC) within Milan criteria. From August 2002 to December 2014, 112 patients (median age, 56.7 years; age range, 22-80 97 men, 15 women) underwent TACE gelatin sponge particle embolization, and 125 56.6 23-82 109 16 embolization. RFA was performed 2 weeks after TACE. Cumulative...
Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.To delineate the spatiotemporal patterns LRR after BCS, we analyzed data 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological treatment specific factors were using Cox proportional hazards model identify predictive for events. Recurrence scrutinized based on recurrence type recurrence-free...
The prognosis of lymph node-negative triple-negative breast cancer (TNBC) is still worse than that other subtypes despite adjuvant chemotherapy. Reliable prognostic biomarkers are required to identify TNBC patients at a high risk distant metastasis and optimize individual treatment.We analyzed the RNA sequencing data primary tumor tissue clinicopathological 202 patients. cohort was randomly divided into training validation sets. Least absolute shrinkage selection operator Cox regression...
Abstract The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures sample preparation and data generation but also comprehensive methods genomics, transcriptomics, proteomics, metabolomics from cancer samples. Furthermore, regarding radiomics pathomics, describes...