A5019430044- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Venomous Animal Envenomation and Studies
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- Radiomics and Machine Learning in Medical Imaging
- Biomedical Text Mining and Ontologies
- Genomics and Rare Diseases
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
- Beetle Biology and Toxicology Studies
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Biochemical and Structural Characterization
- Congenital heart defects research
- RNA Research and Splicing
James S. McDonnell Foundation
2016-2025
Washington University in St. Louis
2019-2024
The University of Texas MD Anderson Cancer Center
2024
University of Roehampton
2020
Haffkine Institute
2014
Transposable elements (TEs) encode regulatory that impact gene expression in multiple species, yet a comprehensive analysis of zebrafish TEs the context regulation is lacking. Here, we systematically investigate epigenomic and transcriptomic landscape across 11 adult tissues using multidimensional sequencing data. We find contribute substantially to diverse array genome 37% are positioned active states tissues. identify TE subfamilies enriched highly specific among different use transcript...
RNAP II switching from the paused to productive transcription elongation state is a pivotal regulatory step that requires specific phosphorylations catalyzed by P-TEFb kinase. Nucleosolic activity inhibited its interaction with ribonuclear protein complex built around 7SK small nuclear RNA (7SK snRNP). MePCE methyltransferase methylates and stabilizes in nucleosol. Here, we report also binds chromatin through histone H4 tail serve as activator at genes important for cellular identity....
Abstract CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer ( www.civicdb.org ) describing the therapeutic, prognostic, and diagnostic relevance inherited somatic variants all types. committed to open source code, access content, public application programming interfaces (APIs), provenance supporting evidence allow transparent creation current accurate variant interpretations use cancer precision medicine.
5068 Background: Treatment with immune checkpoint blockade (ICB) alone results in suboptimal response rates prostate cancer. Prostvac-VF Tricom is a therapeutic vaccine that incorporates DNA for the shared self-antigen PSA. Personalized neoantigen vaccines based on specific mutated epitopes may have ability to overcome immunoresistance seen self-antigens. Even low mutational burden tumors like cancer, T cell responses against neoantigens been correlated favorable clinical outcomes. Thus, we...
Abstract The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures sample preparation and data generation but also comprehensive methods genomics, transcriptomics, proteomics, metabolomics from cancer samples. Furthermore, regarding radiomics pathomics, describes...
Abstract The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures sample preparation and data generation but also comprehensive methods genomics, transcriptomics, proteomics, metabolomics from cancer samples. Furthermore, regarding radiomics pathomics, describes...
Abstract Epigenetic treatment has been studied as a means to augment anti-tumor immune cell activity by increasing the expression of antiviral response genes. Previous studies, including our own, have revealed an additional consequence epigenetic treatment: reactivation transposable elements (TEs). Normally, most TEs are epigenetically repressed in healthy somatic tissues. However, can reactivate previously unannotated promoters, particularly rapidly proliferating cells. These reactivated...
Major histocompatibility complex class II (MHCII) molecules display peptides on antigen-presenting cells (APCs) for inspection by CD4+ T cells. MHCII surface levels and life span are regulated post-translationally peptide loading ubiquitin-dependent lysosomal targeting, but proteases responsible protein degradation remain unidentified. Here, we examined the role of aspartyl in characterised form that is degraded. Exposure immature monocyte-derived dendritic (MoDCs) KG-1 acute myeloid...