A5071971784- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- 14-3-3 protein interactions
- Ferroptosis and cancer prognosis
- Breast Cancer Treatment Studies
- ATP Synthase and ATPases Research
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- Natural product bioactivities and synthesis
- Advanced Breast Cancer Therapies
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Metabolomics and Mass Spectrometry Studies
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
Fudan University Shanghai Cancer Center
2022-2025
Shanghai Medical College of Fudan University
2024-2025
General Hospital of Shenyang Military Region
2024
Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through ubiquitin-proteasome pathway....
Abstract Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially non-Caucasians, remains poorly characterized. We performed large-scale prospective targeted sequencing of matched tumor-blood samples from 4079 Chinese females, coupled detailed clinical annotation, to map between germline somatic alterations. discovered 368 pathogenic variants identified 5 cancer DNA repair-associated genes (BCDGs;...
More than half of the breast cancer initially labeled as human epidermal growth factor receptor 2 (HER2)-negative actually exhibited low HER2 levels (IHC 1+ or IHC 2+/FISH-) and were classified HER2-low cancer. Previous research emphasized significant biological heterogeneity in cancer, highlighting importance accurately characterizing tumors to promote precise management antibody‒drug conjugates. In this study, we established a large-scale targeted sequencing cohort (N = 1907) representing...
Disulfidptosis, a regulated form of cell death, has been recently reported in cancers characterized by high SLC7A11 expression, including invasive breast carcinoma, lung adenocarcinoma, and hepatocellular carcinoma. However, its role colon adenocarcinoma (COAD) infrequently discussed. In this study, we developed validated prognostic model based on 20 disulfidptosis-related genes (DRGs) using LASSO Cox regression analyses. The robustness practicality were assessed via nomogram. Subsequent...
Lymphovascular invasion (LVI) is a crucial step in metastasis and closely associated with poor prognosis patients breast cancer. However, its clinical molecular characteristics remain insufficiently defined. We aimed to identify targets for LVI-positive (LVI+) cancer predict patient via the analysis of genomic variations using targeted sequencing. established large-scale sequencing cohort 4,079 samples, which included 3,159 early-stage locally advanced available LVI statuses. Comparisons...
Metabolic dysregulation is prominent in triple-negative breast cancer (TNBC), yet therapeutic strategies targeting metabolism are limited. Here, utilizing multiomics data from our TNBC cohort (n = 465), we demonstrated widespread splicing deregulation and increased spliceosome abundance the glycolytic subtype. We identified SNRNP200 as a crucial mediator of glucose-driven metabolic reprogramming. Mechanistically, glucose induces acetylation at K1610, preventing its proteasomal degradation....
Abstract Background Triple‐negative breast cancer (TNBC) displays high heterogeneity. The majority of TNBC cases are characterized by Ki‐67 expression. with low expression accounts for only a small fraction and has been relatively less studied. Methods This study analyzed large single‐center multiomics data set, combined single‐cell set. clinical, genomic, metabolic characteristics patients were analyzed. Results clinical pathological in 2217 patients. Low was associated higher patient age...
Endometrial cancer (EC) is the most common gynecologic malignancy with increasing incidence and mortality. The tumor immune microenvironment significantly impacts prognosis. Weighted Gene Co-Expression Network Analysis (WGCNA) a systems biology approach that analyzes gene expression data to uncover co-expression networks functional modules. This study aimed use WGCNA develop prognostic prediction model for EC based on cell infiltration, identify new potential therapeutic targets. was...
<p>Supplementary figures and tables</p>
<p>Supplementary figures and tables</p>
<div>Abstract<p>Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through...
<div>Abstract<p>Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through...
Abstract Background: TNBC displays high heterogeneity and the majority of cases were characterized by a Ki-67 expression. In contrast, with low expression accounts for only small fraction, this subset has been relatively less extensively studied. Methods: Using study institution's largest single-center multi-omics dataset combined single-cell dataset, authors analyzed clinical, genomic, metabolic characteristics patients TNBC. Results: This included total 2217 analysis clinical pathological...