A5087080548- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Breast Cancer Treatment Studies
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- 14-3-3 protein interactions
- Advanced Breast Cancer Therapies
- Spaceflight effects on biology
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA regulation and disease
Fudan University
2025
Shanghai Medical College of Fudan University
2023-2024
Fudan University Shanghai Cancer Center
2022-2024
Triple-negative breast cancer (TNBC) is the deadliest subtype of owing to lack effective therapeutic targets. Splicing factor 3a subunit 2 (SF3A2), a poorly defined splicing factor, was notably elevated in TNBC tissues and promoted progression, as confirmed by cell proliferation, colony formation, transwell migration, invasion assays. Mechanistic investigations revealed that E3 ubiquitin-protein ligase UBR5 ubiquitination-dependent degradation SF3A2, which turn regulated UBR5, thus forming...
Rationale: SUMOylation regulates a plethora of biological processes, and its inhibitors are currently under investigation in clinical trials as anticancer agents.Thus, identifying new targets with site-specific defining their functions will not only provide mechanistic insights into the signaling but also open an avenue for developing strategy cancer therapy.MORC family CW-type zinc finger 2 (MORC2) is newly identified chromatin-remodeling enzyme emerging role DNA damage response (DDR),...
Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through ubiquitin-proteasome pathway....
Hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer (HR+/HER2- BC) is the most common subtype, with high risk of long-term recurrence metastasis. Endocrine therapy (ET) combined cyclin-dependent kinase 4/6 (CDK4/6) inhibitors a standard treatment for advanced/metastatic HR+/HER2- BC, but resistance remains major clinical challenge. We report that kinesin family member C2 (KIFC2) was amplified in approximately 50% its expression associated poor...
Abstract Background Microtubule‐targeing agents (MTAs), such as paclitaxel (PTX) and vincristine (VCR), kill cancer cells through activtion of the spindle assembly checkpoint (SAC) induction mitotic arrest, but development resistance poses significant clinical challenges. Methods Immunoblotting RT‐qPCR were used to investigate potential function related mechanism MORC2. Flow cytometry analyses carried out determine cell cycle distribution apoptosis. The effect MORC2 on cellular sensitivity...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer. Transcriptional dysregulation a hallmark cancer, and several transcriptional regulators have been demonstrated to contribute progression. In this study, we identified an upregulation corepressor downregulator transcription 1-associated protein 1 (DRAP1) in TNBC, which was closely associated with poor recurrence-free survival patients TNBC. DRAP1 promoted TNBC proliferation, migration, invasion vitro tumor growth...
Triple-negative breast cancer (TNBC) is the most fatal subtype of cancer; however, effective treatment strategies for TNBC are lacking. Therefore, it important to explore mechanism metastasis and identify its therapeutic targets. Dysregulation ETHE1 leads ethylmalonic encephalopathy in humans; role remains elusive. Stable cell lines with overexpression or knockdown were constructed biological functions during progression vitro vivo. Mass spectrometry was used analyze molecular through which...
<div>Abstract<p>Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer. Transcriptional dysregulation a hallmark cancer, and several transcriptional regulators have been demonstrated to contribute progression. In this study, we identified an upregulation corepressor downregulator transcription 1–associated protein 1 (DRAP1) in TNBC, which was closely associated with poor recurrence-free survival patients TNBC. DRAP1 promoted TNBC proliferation, migration,...
<div>Abstract<p>Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer. Transcriptional dysregulation a hallmark cancer, and several transcriptional regulators have been demonstrated to contribute progression. In this study, we identified an upregulation corepressor downregulator transcription 1–associated protein 1 (DRAP1) in TNBC, which was closely associated with poor recurrence-free survival patients TNBC. DRAP1 promoted TNBC proliferation, migration,...
<p>This Supplementary Information includes Fig. S1 to S15 and Tables S7.</p>
<p>This Supplementary Information includes Fig. S1 to S15 and Tables S7.</p>
<p>Supplementary figures and tables</p>
<p>Supplementary figures and tables</p>
<div>Abstract<p>Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through...
<div>Abstract<p>Triple-negative breast cancer (TNBC) represents the most lethal subtype of due to its aggressive clinical features and lack effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined role protein phosphatases in TNBC progression chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member subunits, was aberrantly upregulated tissues predicted poor prognosis. PPP1R14B degraded mainly through...