A5067410920- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Epigenetics and DNA Methylation
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Health, Medicine and Society
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Migraine and Headache Studies
- Glycogen Storage Diseases and Myoclonus
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- CNS Lymphoma Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- COVID-19 and Mental Health
Hospital Universitario de La Princesa
2016-2025
Universidad Autónoma de Madrid
2025
Universidad Complutense de Madrid
2022
Hospital Universitario Severo Ochoa
2006-2021
Universidad de Alcalá
2002-2007
Hospital Universitario de Guadalajara
2004
Hospital Universitario 12 De Octubre
1999
Background: Few longitudinal studies have verified the clinical diagnosis of dementia based on examinations. We evaluated consistency over a period 3 years follow-up in population-based, cohort study older people central Spain. Methods: Individuals (N = 5278) were at baseline (1994-1995) and (1997-1998). The evaluation included screening questionnaire for neurological assessment. Results: Dementia consisted 37-item version Mini-Mental State Examination (MMSE) Pfeffer Functional Activities...
Abstract Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this and its relevance for treatment remain unclear. We combine locations abnormalities in IGE (131 coordinates from 21 studies) with human connectome to identify an network. validate by showing alignment structural previously identified areas activated epileptiform discharges simultaneous electroencephalogram-functional magnetic resonance imaging. The topography aligns networks involved motor...
We conducted a case-control study searching for possible role of environment in the risk essential tremor (ET). interviewed 142 ET patients and 284 age- sex-matched controls about family history ET, exposure to environmental products containing lead, mercury, manganese, solvents beta-carbolines, agricultural work, well water, pesticides, cigarette smoking alcohol drinking habits. In univariate study, reported smelting, frosted glass, paintings, wheat, corn, barley were more frequent patient...
Neurologic manifestations of HIV infection are quite diverse and can develop into seizures. Because new drug therapies have been developed, it is important to know the interactions between antiretroviral antiepileptic agents. A 36-year-old patient with developed a set progressive left hemiparesis secondarily generalized partial seizures related multifocal leukoencephalopathy. Phenytoin carbamazepine were necessary control Instead therapies, viral load was increased. Protease inhibitors...
Abstract Rett syndrome (RTT) is an early-onset neurodevelopmental disorder that almost exclusively affects girls and totally disabling. Three genes have been identified cause RTT: MECP2 , CDKL5 FOXG1 . However, the etiology of some RTT patients still remains unknown. Recently, next generation sequencing (NGS) has promoted genetic diagnoses because quickness affordability method. To evaluate usefulness NGS in diagnosis, we present study RTT-like using different techniques based on this...
Abstract Perampanel, a non‐competitive antagonist of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptors, is most recent antiepileptic drug available in Spain, marketed January 2014. It was initially approved by European Medicines Agency as adjunctive treatment for partial‐onset seizures patients 12 years and older, but recently also primary generalized tonic‐clonic seizures. Although clinical trials provide essential information about drug, they do not reflect daily...
We describe clinical, cerebrospinal fluid (CSF), and magnetic resonance imaging (MRI) findings in a patient with general paresis. MRI demonstrated cortical-subcortical atrophy broad-coalescent high-intensity T2 lesions right frontotemporal lobes.After intravenous penicillin therapy, the size of these diminished dramatically. That regression correlated improvement neuropsychologic test CSF analysis.To our knowledge, this is first case reported literature MRI-reversible suggest that prognostic...
Abstract Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since gene located on X chromosome, chromosome inactivation (XCI) could play role wide range of phenotypic variation RTT patients; however, classical methylation-based protocols to evaluate XCI not determine whether preferentially inactivated carried mutant or wild-type allele. Therefore, we developed an allele-specific assay methylation at loci several recurrent mutations. We...
In recent years, a benign variant of frontotemporal lobar degeneration (FTLD) has been recognized, with particularly slow progression cognitive deficits and scarce atrophy or hypoperfusion in neuroimaging studies. Patients FTLD have considered "phenocopies," an underlying nondegenerative neurologic process.We report the first family three affected members having associated C9ORF72 gene hexanucleotide expansion. Onset symptoms occurred during fifth decade, naming memory problems as main...
Lymphomatosis cerebri (LC) is an infrequent type of primary lymphoma the central nervous system that characterised by diffuse, infiltrating involvement white matter brain without formation a mass.To report case patient with LC in order to draw attention this disease, which rarely diagnosed, and its initial presentation magnetic resonance imaging (MRI) as leukoencephalopathy.Our was 56-year-old female who had clinical signs symptoms sub-acute dementia. Computerised axial tomography MRI head...
The purpose of this work was to study the characteristics behavioural disorders (non-cognitive or neuropsychiatric symptoms) presented by subjects with Alzheimer's disease from a sample population together their relation cognitive and functional impairment suffered these patients.NEDICES is longitudinal populational based on census neurological diseases in above age 64. In 2001, conducted situation 83 who had started suffering between 1994 1997. Due death number other reasons, only 32 them...
Hypnic headache is a condition characterized by nocturnal episodes of which periodically waken the sleeping patient. They usually occur in persons over 55 years age and are thought to be due some type disturbance biological rhythm.A 70 year old woman, with no relevant past history, complained that during previous 12-14 months she had been woken from sleep headache. The was diffuse, non-pulsatile very intense. duration variable, 15 45 minutes disappeared without requiring analgesics. pain not...
Tras la activación del código ictus, hasta un 30% de los pacientes presentan cuadros imitadores siendo epilepsia el más frecuente. Evaluamos utilidad TC cerebral multiparamétrica para diferenciación déficit origen comicial versus vascular. Estudio observacional retrospectivo con recogida prospectiva datos. Se revisan imágenes atendidos como ictus durante año que finalmente fueron diagnosticados etiología comicial. N = 11 (varones 36%, edad media 74,5 años). Tres presentaban focalidad...
The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles.We describe two patients with a predominantly choreic disease, who experience improvement of after introduction olanzapine their treatment, being this drug well tolerated.The chorea suggests that has dopaminergic D2 receptors blocking action.
Objectives The novel coronavirus disease (COVID-19) pandemic has led to social distancing measures and impaired medical care of chronic neurological diseases, including epilepsy, which may have adversely affected well-being quality life patients with epilepsy (PWE). objective this study is evaluate the impact COVID-19 in levels anxiety, depression, somnolence, using validated scales PWE real-life clinical practice. Materials & Methods Self-administered anxiety disorders (GAD-7), depression...
Abstract Background and purpose Stroke mimics (SMs) account for a significant number of patients attended as stroke code (SC) with an increasing over the years. Recent studies show perfusion computed tomography (PCT) alterations in some SMs, especially seizures. The objective our study was to evaluate clinical characteristics PCT SMs SC order identify potential predictors SMs. Methods A retrospective performed including all activations undergoing multimodal CT non‐enhanced (CT), angiography...