A5057627735- Liver physiology and pathology
- Liver Disease and Transplantation
- Hippo pathway signaling and YAP/TAZ
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Blood properties and coagulation
- Histiocytic Disorders and Treatments
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Sulfur Compounds in Biology
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Fibroblast Growth Factor Research
- Surgical Sutures and Adhesives
- Hepatitis B Virus Studies
Sichuan University
2020-2024
State Key Laboratory of Biotherapy
2020-2024
Fuzhou University
2020-2022
Wound dressings with asymmetric wettability surfaces can effectively prevent bacterial colonization and tissue dehydration have shown great potential for diabetic wound healing applications. However, the construction of a highly hydrophobic outer surface high biocompatibility permeability is still major challenge in preparation wettable dressings. Inspired by superhydrophobic structures existing nature, an composite dressing layer was successfully prepared this study. The fabricated...
Epigenetic targeting of the maladaptive vascular niche in fibrotic liver blocks fibrosis by alleviating fibrogenic angiocrine IGFBP7 and ADAMTS1.
Dysfunction of the vascular angiocrine system is critically involved in regenerative defects and fibrosis injured organs. Previous studies have identified various factors found that risk such as aging metabolic disorders can disturb fibrotic One existing key gap what sense to modulate organ fibrosis. Here, using human mouse data, we discovered pathway hydrogen sulfide (H
Kidney fibrosis is accompanied by vascular dysfunction. Discovering new ways to ameliorate dysfunctional angiogenesis may bypass kidney fibrosis. YAP (Yes-associated protein) plays a multifaceted role during angiogenesis. Here, we found that selectively targeting signaling in the endothelium ameliorates unilateral ureteral obstruction (UUO)-induced Genetic deletion of Yap1, encoding protein, VE-cadherin+ endothelial cells inhibited endothelial-to-mesenchymal transition (EndMT) and improved...
Mammalian cells are extremely vulnerable to external assaults compared with plant and microbial because of the weakness cell membranes walls. Construction ultrathin robust artificial shells on mammalian biocompatible materials is a promising strategy for protecting single against harsh environmental conditions. Herein, layer-by-layer assembly combined transglutaminase-catalyzed cross-linking reaction was employed prepare cross-linked gelatin nanoshells individual human cervical carcinoma...
Cell surface engineering technologies can regulate cell function and behavior by modifying the surface. Previous studies have mainly focused on investigating effects of reactions materials activity. However, they do not comprehensively analyze other cellular processes. This study exploits covalent bonding, hydrophobic interactions, electrostatic interactions to modify macromolecules succinimide ester-methoxy polyethylene glycol (NHS-mPEG), distearoyl phosphoethanolamine-methoxy (DSPE-mPEG),...
Chronic or overwhelming liver injury is frequently associated with fibrosis, which the main histological characteristic of non-alcoholic steatohepatitis (NASH). Currently, there no effective treatment for fibrosis. Adaptive immunity one perpetrators inflammation and involves antigen-specific activation lymphocytes. Targeting adaptive has been proposed as a novel therapeutic approach NASH. In this study, we demonstrated that sinusoidal endothelial cells (LSECs) contribute to MHC class II...