A5100769010- Epigenetics and DNA Methylation
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Liver physiology and pathology
- Radical Photochemical Reactions
- Synthesis of Organic Compounds
- Oxidative Organic Chemistry Reactions
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
China Pharmaceutical University
2020-2024
State Key Laboratory of Natural Medicine
2024
Hai Kang Life (China)
2024
State Key Laboratory of Biotherapy
2021
Sichuan University
2021
Alanine-serine-cysteine transporter 2 (ASCT2) is up-regulated in lung cancers, and inhibiting it could potentially lead to nutrient deprivation, making a viable strategy for cancer treatment. In this study, we present series of ASCT2 inhibitors based on aminobutanoic acids, which exhibit potent inhibitory activity. Two compounds, 20k 25e, were identified as novel inhibitors, with IC50 values at the micromolar level both A549 HEK293 cells, effectively blocking glutamine (Gln) uptake....
Epigenetic targeting of the maladaptive vascular niche in fibrotic liver blocks fibrosis by alleviating fibrogenic angiocrine IGFBP7 and ADAMTS1.
Eucalyptus globulus is widely introduced and cultivated in Yunnan province. Its foliage mainly used to extract eucalyptus oil, but the by-product residue has not been fully utilized. Based on above reasons, this study, we sought explore comprehensive utilization potential of resources. The total composition was analyzed by ultra performance liquid chromatography-time-of-flight mass spectrometry (UPLC-Q/TOF MS), active components nutrient leaf were determined chemical methods phase...
An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening scale-up preparation have also been accomplished, selected compounds were evaluated their photophysical properties.