A5013734460- Tryptophan and brain disorders
- Advanced Proteomics Techniques and Applications
- Schizophrenia research and treatment
- Health, Environment, Cognitive Aging
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Complement system in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Antifungal resistance and susceptibility
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- Mental Health Research Topics
- Advanced Biosensing Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Mental Health and Psychiatry
- Neurogenesis and neuroplasticity mechanisms
- Amino Acid Enzymes and Metabolism
Royal College of Surgeons in Ireland
2016-2025
Beaumont Hospital
2007-2024
Jena University Hospital
2022
Royal College of Surgeons of England
2018
Gesundheitsamt
2009
Robert Koch Institute
2009
Max Planck Institute for Metabolism Research
2002-2006
Max Planck Society
2003
University of Cologne
2002
In vivo monitoring of stem cells after grafting is essential for a better understanding their migrational dynamics and differentiation processes regeneration potential. Migration endogenous or grafted neurons has been described in vertebrate brain, both under normal conditions from the subventricular zone along rostral migratory stream pathophysiological conditions, such as degeneration focal cerebral ischemia. Those studies, however, relied on invasive analysis brain sections combination...
The therapeutical potential of transplantation undifferentiated and predifferentiated murine embryonic stem cells for the regeneration injured brain was investigated in two rodent stroke models. Undifferentiated xenotransplanted into rat at hemisphere opposite to ischemic injury migrated along corpus callosum towards damaged tissue differentiated neurons border zone lesion. In homologous mouse brain, same did not migrate, but produced highly malignant teratocarcinomas site implantation,...
Delta-aminolevulinic acid (ALA) is the precursor of porphyrin synthesis and has been recently used in vitro clinical studies as an endogenous photosensitizer for photodynamic therapy treatment various tumors. For this purpose, ALA given topically, systemically, or orally. When administered by oral route, it shows excellent intestinal absorption. also efficiently reabsorbed renal proximal tubule after glomerular filtration. However, pathways mechanisms its transmembrane transport into...
Abstract The mechanisms underlying white matter changes in psychiatric disease are not known. We aimed to characterise the differential protein expression deep from dorsolateral prefrontal cortex 35 schizophrenia, bipolar disorder, and control subjects, Stanley Array Collection. used 2‐D DIGE profile for brain. found 70 spots be significantly differentially expressed between subjects (ANCOVA, p <0.05), 46 of which were subsequently identified by LC‐MS/MS. proteins included novel...
Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel insights into cellular pathology of schizophrenia. We used discovery-based proteomics and targeted functional analyses reveal reductions in 17 ribosomal proteins, with an 18% decrease total signal intensity schizophrenia-patient-derived ONS cells. quantified rates global protein synthesis vitro found a significant reduction rate schizophrenia patient-derived compared control-derived Protein fibroblast cell...
Importance Biomarkers that are predictive of outcomes in individuals at risk psychosis would facilitate individualized prognosis and stratification strategies. Objective To investigate whether proteomic biomarkers may aid prediction transition to psychotic disorder the clinical high-risk (CHR) state adolescent experiences (PEs) general population. Design, Setting, Participants This diagnostic study comprised 2 case-control studies nested within European Network National Schizophrenia...
<h3>Context</h3> The hippocampus is strongly implicated in schizophrenia and, to a lesser degree, bipolar disorder. Proteomic investigations of the different regions may help us clarify basis and disease specificity changes. <h3>Objective</h3> To determine whether disorder are associated with distinct patterns differential protein expression specific hippocampus. <h3>Design, Setting, Patients</h3> A postmortem comparative proteomic study, including validation expression, was performed....
Low-grade inflammation may occur in association with several mental disorders of early adulthood, though associations markers chronic such as soluble urokinase plasminogen activator receptor (suPAR) are less well-established. We aimed to examine between acute and inflammatory disorders, well psychiatric co-morbidity, young adults aged 24 years the Avon Longitudinal Study Parents Children.Included were 781 participants (of 4019 who attended at age years) completed assessments provided plasma...
The postsynaptic density (PSD) contains a complex set of proteins known relevance to neuropsychiatric disorders such as schizophrenia and bipolar disorder. We enriched for this anatomical structure in the anterior cingulate cortex 16 disorder samples 20 controls from Stanley Medical Research Institute. Unbiased shotgun proteomics incorporating label-free quantitation was used identify differentially expressed proteins. Quantitative investigation PSD identified 2033 proteins, among which 288...
The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to underlying pathophysiological mechanisms. We undertook first proteomic profiling blood plasma samples children who later develop a PD. Participants were recruited from UK Avon Longitudinal Study Parents and Children (ALSPAC) cohort also participated in psychiatric assessment interviews at age 18. Protein expression levels 11 compared between individuals developed...
Abstract The complement cascade is a major component of the immune defence against infection, and there increasing evidence for role dysregulated in psychiatric disorders. We undertook directed proteomic analysis signalling pathway ( n = 29 proteins) using data-independent acquisition. Participants were recruited from UK avon longitudinal study parents children (ALSPAC) cohort who participated assessment interviews at ages 12 18. Protein expression levels age among individuals reported...
Abstract Background and Hypothesis Treatment response to specific antipsychotic medications is difficult predict on clinical grounds alone. The current study hypothesizes that the baseline complement pathway activity predicts treatment investigates relationship between plasma biomarkers with medications. Study Design Baseline samples were collected from first episode of psychosis patients (n = 243) a multi-center trial. participants treated amisulpride for 4 weeks. Levels coagulation...
<title>Abstract</title> Dysregulation of inflammatory mediators and complement cascade proteins has been implicated in psychosis. In the current study, we aimed to investigate relationship between cytokines blood from people at clinical high risk (CHR) for psychosis first episode (FEP). Baseline samples two cohorts CHR participants [NEURAPRO (n = 153) STEP 146)], one cohort FEP patients [OPTiMiSE 226)] were included. The levels three Inflammatory markers including Interleukin (IL)-6, Tumour...
The identification of biomarkers transition from the at-risk mental state (ARMS) to psychotic disorder is important because early treatment psychosis associated with improved outcome. Increasing evidence points an inflammatory contribution psychosis. We questioned whether raised levels plasma markers predict ARMS and any such predictors could be reduced by omega-3 (ω-3) polyunsaturated fatty acids (PUFAs).We measured 40 neuroinflammation using a commercially available immunoassay kit....
Maternal infection is a risk factor for schizophrenia but the molecular and cellular mechanisms are not fully known. Myelin abnormalities amongst most robust neuropathological changes observed in schizophrenia, preliminary evidence suggests that prenatal inflammation may play role.Label-free liquid chromatography-mass spectrometry was performed on prefrontal cortex (PFC) of adult rat offspring born to dams were exposed gestational day 15 viral mimic polyinosinic:polycytidylic acid...