A5015356138- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Motor Control and Adaptation
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Music Perception
- Face Recognition and Perception
- Muscle activation and electromyography studies
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Cognitive Functions and Memory
- Behavioral and Psychological Studies
- Action Observation and Synchronization
- Analog and Mixed-Signal Circuit Design
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neural Engineering
- Decision-Making and Behavioral Economics
- Neurobiology of Language and Bilingualism
- Neurotransmitter Receptor Influence on Behavior
- Blind Source Separation Techniques
- Bipolar Disorder and Treatment
University of Iowa
2015-2024
University of Iowa Hospitals and Clinics
2016-2024
KU Leuven
2020
Max Planck Institute for Empirical Aesthetics
2020
University of the Russian Academy of Education
2020
University of California, San Diego
2011-2016
Leibniz Institute for High Performance Microelectronics
2013
Max Planck Institute for Metabolism Research
2008-2012
Max Planck Society
2008
Response inhibition is essential for navigating everyday life. Its derailment considered integral to numerous neurological and psychiatric disorders, more generally, a wide range of behavioral health problems. Response-inhibition efficiency furthermore correlates with treatment outcome in some these conditions. The stop-signal task an tool determine how quickly response implemented. Despite its apparent simplicity, there are many features (ranging from design data analysis) that vary across...
Abstract Inhibitory control enables humans to stop prepotent motor activity, and is commonly studied using go/no‐go or stop‐signal tasks. In tasks, activity elicited by delaying signals relative go signals. however, trials include only one signal—go no‐go. Hence, has be ensured differently—for example, rare no‐go short trial durations. However, a literature survey shows that ∼40% of studies use equiprobable ∼20% long stimulus‐stimulus intervals (> 4 s). It unclear whether such slow‐paced,...
The frontocentral P3 event-related potential has been proposed as a neural marker of response inhibition. However, this association is disputed: some argue that latency too late relative to the timing action stopping (stop-signal reaction time; SSRT) index We tested whether onset inhibition, and it coincides with predicted by neurocomputational models. measured EEG in 62 participants during stop-signal task, used independent component analysis permutation statistics measure each participant....
According to recent accounts, the processing of errors and generally infrequent, surprising (novel) events share a common neuroanatomical substrate. Direct empirical evidence for this network in humans is, however, scarce. To test hypothesis, we administered hybrid error-monitoring/novelty-oddball task which frequency novel, trials was dynamically matched errors. Using scalp electroencephalographic recordings event-related functional magnetic resonance imaging (fMRI), compared neural...
Abstract The differences between erroneous actions that are consciously perceived as errors and those go unnoticed have recently become an issue in the field of performance monitoring. In EEG studies, error awareness has been suggested to influence positivity (Pe) response-locked event-related brain potential, a positive voltage deflection prominent approximately 300 msec after commission, whereas preceding error-related negativity (ERN) seemed be unaffected by awareness. Erroneous actions,...
Abstract The ability to detect and correct action errors is paramount safe efficient goal‐directed behaviors. Existing work on the neural underpinnings of error processing post‐error behavioral adaptations has led development several mechanistic theories processing. These can be roughly grouped into adaptive maladaptive theories. While propose that trigger a cascade processes will result in improved behavior after commission, hold commission momentarily impairs behavior. Neither group...
The neurophysiological basis of motor control is substantial interest to basic researchers and clinicians alike. Motor processes are accompanied by prominent field potential changes in the β-frequency band (15–29 Hz): trial-averages, movement initiation β-band desynchronization over sensorimotor areas, whereas cancellation β-power increases (pre)frontal areas. However, averaging misrepresents true nature β-signal. Unaveraged activity characterized short-lasting, burst-like events, rather...
When an unexpected event occurs in everyday life (e.g., a car honking), one experiences slowing down of ongoing action walking into the street). Motor following events is ubiquitous phenomenon, both laboratory experiments as well such situations, yet underlying mechanism unknown. We hypothesized that recruit same inhibition network brain does complete cancellation (i.e., action-stopping). Using electroencephalography and independent component analysis humans, we show signature successful...
An arrow version of the Eriksen flanker task was employed to investigate influence conflict on error-related negativity (ERN). The degree modulated by varying distance between flankers and target (CLOSE FAR conditions). Error rates reaction time data from a behavioral experiment were used adapt connectionist model this task. This based monitoring theory simulated event-related potential data. computational predicted an increased ERN amplitude in incompatible (the low-conflict condition)...
Abstract Surprising events markedly affect behaviour and cognition, yet the underlying mechanism is unclear. Surprise recruits a brain that globally suppresses motor activity, ostensibly via subthalamic nucleus (STN) of basal ganglia. Here, we tested whether this suppressive extends beyond skeletomotor suppression also affects cognition (here, verbal working memory, WM). We recorded scalp-EEG (electrophysiology) in healthy participants STN local field potentials Parkinson’s patients during...
The subthalamic nucleus is a key site controlling motor function in humans. Deep brain stimulation of the can improve movements patients with Parkinson's disease; however, for unclear reasons, it also have cognitive effects. Here, we show that human monosynaptically connected areas such as prefrontal cortex. Single neurons and field potentials are modulated during processing coherent 4-Hz oscillations medial These data predict low-frequency deep may alleviate deficits disease patients. In...
Many studies have examined the rapid stopping of action as a proxy human self-control. Several methods shown that critical focus for is right inferior frontal cortex. Moreover, electrocorticography beta band power increases in cortex and BG successful versus failed stop trials, before time elapses, perhaps underpinning prefrontal-BG network inhibitory control. Here, we tested whether same signature might be visible scalp electroencephalography (EEG)-which would open important avenues using...
Rapid action stopping leads to global motor suppression. This is shown by studies using transcranial magnetic stimulation measure corticospinal excitability of task-unrelated effectors (e.g., from the hand during speech stopping). We hypothesize that this suppression relates STN basal ganglia. Several local field potential in PD patients have increased ß-band power successful stopping.
There is growing awareness across the neuroscience community that replicability of findings about relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power adhere to well-defined standardised analysis pipelines. Inspired recent efforts from psychological sciences, desire examine some foundational using electroencephalography (EEG), we have launched #EEGManyLabs, a large-scale international collaborative replication effort....
The right inferior frontal cortex (rIFC) is important for stopping responses. Recent research shows that it also activated when response emission slowed down anticipated. This suggests rIFC functions as a goal-driven brake. Here, we investigated the causal role of in braking by using computer-controlled, event-related (chronometric), direct electrical stimulation (DES). We compared effects on trials which responses were made presence versus absence stopping-goal (“Maybe Stop” [MS] vs “No...
Motor inhibition is a cognitive control ability that allows humans to stop actions rapidly even after initiation. Understanding and improving motor could benefit adaptive behavior in both health disease. We recently found presenting surprising, task-unrelated sounds when stopping necessary improves the likelihood of successful stopping. In current study, we investigated neural underpinnings this effect. Specifically, tested whether surprise-related improvements are due genuine increase...
Stopping inappropriate eye movements is a cognitive control function that allows humans to perform well in situations demand attentional focus. The stop-signal task an experimental model for this behavior. Participants initiate saccade toward target and occasionally have try stop the impending if signal occurs. Prior research using version of paradigm limb (hand, leg) as speech has shown rapidly stopping action leads apparently global suppression motor system, indexed by corticospinal...
To effectively interact with their environment, humans must often select actions from multiple incompatible options. Existing theories propose that during motoric response-conflict, inappropriate motor activity is actively (and perhaps non-selectively) suppressed by an inhibitory fronto-basal ganglia mechanism. We here tested this theory across three experiments. First, using scalp-EEG, we found both outright action-stopping and response-conflict action-selection invoke low-frequency of a...
The ability to stop an already initiated action is paramount adaptive behavior. Much scientific debate in the field of human action-stopping currently focuses on two interrelated questions. (1) Which cognitive and neural processes uniquely underpin implementation inhibitory control when actions are stopped after explicit signals, which instead commonly evoked by all salient even those that do not require stopping? (2) Why purported (neuro)physiological signatures inhibition occur at...