A5050190225- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Geriatric Care and Nursing Homes
- Alzheimer's disease research and treatments
- Palliative Care and End-of-Life Issues
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Intensive Care Unit Cognitive Disorders
- EEG and Brain-Computer Interfaces
- Amyotrophic Lateral Sclerosis Research
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Retinal Diseases and Treatments
- Aging, Health, and Disability
- Dysphagia Assessment and Management
- Color perception and design
- Craniofacial Disorders and Treatments
- Mental Health and Patient Involvement
- COVID-19 and healthcare impacts
- Neurological Disorders and Treatments
National Hospital for Neurology and Neurosurgery
2014-2024
University College London
2014-2024
University Hospitals Sussex NHS Foundation Trust
2024
Greater Manchester Mental Health NHS Foundation Trust
2024
Bangor University
2024
University of Brighton
2024
University of Manchester
2024
UK Dementia Research Institute
2013-2024
NIHR Queen Square Dementia Biomedical Research Unit
2023
Bournemouth University
2022
Neuropathological studies suggest that the basal forebrain cholinergic system (BFCS) is affected in Alzheimer's disease (AD), but there no vivo evidence of early damage to this subjects at high risk developing AD. Here, we found mild cognitive impairment (MCI) patients exhibited significant volume reduction nucleus basalis Meynert (NbM) using recently developed probabilistic maps BFCS space. In addition, volumes different magnocellular compartments varied significantly with regional gray...
Logopenic variant primary progressive aphasia (lvPPA) is a major presentation of Alzheimer's disease (AD) that signals the importance communication dysfunction across AD phenotypes. A clinical staging system lacking for evolution AD-associated difficulties could guide diagnosis and care planning. Our aim was to create symptom-based scheme lvPPA, identifying functional milestones relevant broader spectrum.
Abstract Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and of posterior brain regions. With the majority cases attributable to Alzheimer’s disease recent evidence for genetic risk factors specifically related atrophy, can provide important insights into selective vulnerability phenotypic diversity. The present study describes first major longitudinal investigation progression. Three hundred sixty-one individuals (117...
Abstract Frontotemporal dementia (FTD) is one of the leading causes before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, other socioeconomic factors; current research practice, however, mainly based on studies conducted in North America Western Europe. Changes diagnostic criteria procedures well new adapted cognitive tests...
Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome characterized by early progressive visual dysfunction in the context of relative preservation memory and pattern mainly involving posterior cortex. The aim present study to characterize neuropsychiatric profile PCA.The Neuropsychiatric Inventory was used assess 12 symptoms (NPS) 28 patients with PCA 34 typical Alzheimer disease (AD) matched age, duration, illness severity.The most commonly reported NPS both groups were...
The Rare Dementia Support (RDS) Impact study will be the first major of value multicomponent support groups for people living with or supporting someone a rare form dementia. multicentre aims to evaluate impact offered and delivered dementia, comprising following five work packages (WPs): (a) longitudinal cohort interviews, (b) theoretical development, (c) developing measures, (d) novel interventions, (e) economic analysis.This is mixed-methods design, including (quantitative qualitative)...
Abstract Objective To assess whether high levels of cerebrospinal fluid neurogranin are found in atypical as well typical Alzheimer's disease. Methods Immunoassays were used to measure 114 participants including healthy controls ( n = 27), biomarker‐proven amnestic disease 68), and the visual variant 19) according international criteria. CSF total‐tau, Aβ42, neurofilament light concentrations investigated using commercially available assays. All affected individuals had T1‐weighted...
Patients with semantic dementia (SD) can rapidly and successfully re-learn word labels during cognitive intervention. This new learning, however, usually remains rigid context-dependent. Conceptual enrichment (COEN) training is a therapy approach aimed to produce more flexible generalisable learning in SD. In this study we compare generalisation maintenance of after COEN performance achieved using classical naming (NT). The recruited 62-year-old woman An AB1ACAB2 experimental design was...
Patients with semantic dementia (SD) may undergo successful relearning of object names, but these gains are usually restricted to the trained exemplars, demonstrating poor generalization. We hypothesized that generalization could be improved by restoring an item's network through specific strategies recruit remaining personal memories (conceptual enrichment therapies). describe case a patient SD who showed greater learning following conceptual therapy than when items in word-retrieval...
OPINION article Front. Neurol., 10 June 2020Sec. Dementia and Neurodegenerative Diseases https://doi.org/10.3389/fneur.2020.00458
The WHO Dementia Global Action Plan states that rehabilitation services for dementia are required to promote health, reduce disability, and maintain quality of life those living with dementia. Current services, however, scarce, particularly people young-onset (YOD). This article, written by an international group multidisciplinary specialists, offers a three-part overview the development YOD. Firstly, we provide synthesis knowledge on current evidence-based rehabilitative therapies...