A5008314684- Spatial Neglect and Hemispheric Dysfunction
- Gaze Tracking and Assistive Technology
- Dementia and Cognitive Impairment Research
- Reading and Literacy Development
- Retinal Imaging and Analysis
- Neurobiology of Language and Bilingualism
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Language Development and Disorders
- Tactile and Sensory Interactions
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Hemispheric Asymmetry in Neuroscience
- Hearing Impairment and Communication
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Cognitive Science and Education Research
- Action Observation and Synchronization
- Bayesian Methods and Mixture Models
- Statistical Methods and Bayesian Inference
- AI-based Problem Solving and Planning
- Text Readability and Simplification
- Visual Attention and Saliency Detection
Libera Università Maria SS. Assunta
2018-2025
UK Dementia Research Institute
2015-2023
University College London
2015-2023
National Hospital for Neurology and Neurosurgery
2015-2019
Fondazione Santa Lucia
2013-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Sapienza University of Rome
2013-2016
A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition syndrome in a variety research settings.
Abstract Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and of posterior brain regions. With the majority cases attributable to Alzheimer’s disease recent evidence for genetic risk factors specifically related atrophy, can provide important insights into selective vulnerability phenotypic diversity. The present study describes first major longitudinal investigation progression. Three hundred sixty-one individuals (117...
Young onset Alzheimer's disease (YOAD) is defined as symptom before the age of 65, and particularly associated with phenotypic heterogeneity. Atypical presentations, such clinic-radiological visual syndrome Posterior Cortical Atrophy (PCA), often lead to delays in accurate diagnosis. Eyetracking has been used demonstrate basic oculomotor impairments individuals dementia. In present study, we aim explore relationship between eyetracking metrics standard tests cognition YOAD. Fifty-seven...
Abstract Introduction This work aims to characterize the sequence in which cognitive deficits appear two dementia syndromes. Methods Event‐based modeling estimated fine‐grained sequences of decline clinically‐diagnosed posterior cortical atrophy (PCA) () and typical Alzheimer's disease (tAD) at UCL Dementia Research Centre. Our neuropsychological battery assessed memory, vision, arithmetic, general cognition. We adapted event‐based model handle highly non‐Gaussian data such as test scores...
Eye-tracking technology is an innovative tool that holds promise for enhancing dementia screening. In this work, we introduce a novel way of extracting salient features directly from the raw eye-tracking data mixed sample patients during instruction-less cognitive test. Our approach based on self-supervised representation learning where, by training initially deep neural network to solve pretext task using well-defined available labels (e.g. recognising distinct activities in healthy...
In reading aloud, the eye typically leads over voice position. present study, movements and utterances were simultaneously recorded tracked during of a meaningful text to evaluate eye-voice lead in 16 dyslexic same-age control readers. Dyslexic children slower than peers texts. Their slowness was characterized by great number silent pauses sounding-out behaviors small lengthening word articulation times. Regarding movements, readers made many more fixations (and generally smaller rightward...
<ns4:p>Crowding is a major limitation of visual perception. Because crowding, simple object, like letter, can only be recognized if clutter certain <ns4:italic>critical spacing </ns4:italic>away. Crowding weakly associated with acuity. The critical crowding lowest in the normal fovea, and grows increasing eccentricity peripheral vision. Foveal more prominent patient groups, including those strabismic amblyopia apperceptive agnosia. may lessen age during childhood as reading speed increases....
Adults read at high speed, but estimates of their reading rate vary greatly, i.e., from 100 to 1500 words per minute (wpm). This discrepancy is likely due different recording methods and the perceptual cognitive processes involved in specific test conditions. The present study investigated origins these notable differences RSVP (RR). In six experiments we role many variables. presence a mask caused steep decline rate, with an estimated masking cost about 200 wpm. When decoding process was...
Abstract The Conceptual Feature ( ACF ) framework predicts that word meaning is represented within a high‐dimensional semantic space bounded by weighted contributions of perceptual, affective, and encyclopedic information. , like latent analysis, amenable to distance metrics between any two words. We applied predictions the abstract words using eyetracking via an adaptation classical “visual paradigm” (VWP). Healthy adults n = 20) selected lexical item most related probe in 4‐item written...
Eyetracking technology has had limited application in the dementia field to date, with most studies attempting discriminate syndrome subgroups on basis of basic oculomotor functions rather than higher-order cognitive abilities. Eyetracking-based tasks may also offer opportunities reduce or ameliorate problems associated standard paper-and-pencil tests such as complexity and linguistic demands verbal test instructions, tiredness attention lengthy that generate few data points at a slow rate....
Visual processing deficits in Alzheimer's disease are associated with diminished functional independence. While environmental adaptations have been proposed to promote independence, recent guidance gives limited consideration such and offers conflicting recommendations for people dementia. We evaluated the effects of clutter color contrasts on performances everyday actions posterior cortical atrophy memory-led typical disease.15 patients atrophy, 11 16 healthy controls were asked pick up a...
Studies in the literature have shown how preference towards local or global processing can vary according to different characteristics of stimuli involved, such as stimulus type and time duration. In present study, we investigated whether letters faces undergo similar global/local attentional mechanisms that might be linked eventual differences. We used hierarchical, congruent, incongruent conditions (180 500 ms) conducted three experiments. The results Experiment 1 showed with for 180 ms,...
Although omission and substitution errors in neglect dyslexia (ND) patients have always been considered as different manifestations of the same acquired reading disorder, recently, we proposed a new dual mechanism model. While omissions are related to exploratory disorder which characterizes unilateral spatial neglect, substitutions due perceptual integration mechanism. A consequence this hypothesis is that specific training for omission-type ND would aim at restoring oculo-motor scanning...
Recent findings from English and Russian have shown that grammatical category plays a key role in stress assignment. In these languages, some categories typical pattern this information is used by readers. However, whether readers are sensitive to smaller distributional differences other morpho-syntactic properties (e.g., gender, number, person) remains unclear. We addressed issue word non-word reading Italian, language which: (1) nouns verbs differ the proportion of words with dominant...
This study explores whether semantic processing in parafoveal reading the Italian language is modulated by perceptual and lexical features of stimuli analyzing results rapid parallel visual presentation (RPVP) paradigm experiment, which simultaneously presented two words, with one fovea parafovea. The words were randomly sampled from a set semantically related unrelated pairs. accuracy reaction times measured as function stimulus length written word frequency. Fewer errors observed when they...
Acquired Neglect Dyslexia is often associated with right-hemisphere brain damage and mainly characterized by omissions substitutions in reading single words. Martelli et al. proposed 2011 that these two types of error are due to different mechanisms. Omissions should depend on neglect plus an oculomotor deficit, whilst the difficulty which letters perceptually segregated from each other (i.e., crowding phenomenon). In this study, we hypothesized a deficit focal attention could determine...
Posterior cortical atrophy (PCA) is a degenerative condition characterized by progressive deterioration of visual processing. Dyslexia constitutes an early and frequent symptom the disease previous comprehensive investigations in series individuals have extensively documented characteristic abundance errors as most prevalent error category this population. Here we describe profile patient with PCA, C.P., who presents unusual prevalence phonological, instead purely visual, his reading,...
Simultanagnosia, a deficit in holistic visual perception, is among the most prominent features of posterior cortical atrophy (PCA). Deficits visuoperceptual and attentional mechanisms could contribute to simultanagnosia. In present study, we explored impaired perception global configuration with two main hypotheses: (a) It due processing low-spatial frequency stimuli, (b) it arises from deficits adjusting focus.